[1]徐伟,杨涛,解传滨,等. 质子点扫描技术与光子Tomotherapy在前列腺癌应用中的剂量学比较[J].中国医学物理学杂志,2019,36(10):1129-1133.[doi:DOI:10.3969/j.issn.1005-202X.2019.10.003]
　XU Wei,YANG Tao,XIE Chuanbin,et al. Dosimetric comparison between single spot scanning of proton therapy and tomotherapy for prostate cancer[J].Chinese Journal of Medical Physics,2019,36(10):1129-1133.[doi:DOI:10.3969/j.issn.1005-202X.2019.10.003]
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 质子点扫描技术与光子Tomotherapy在前列腺癌应用中的剂量学比较()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第10期
页码:
1129-1133
栏目:
医学放射物理
出版日期:
2019-10-29

文章信息/Info

Title:
 Dosimetric comparison between single spot scanning of proton therapy and tomotherapy for prostate cancer
文章编号:
1005-202X（2019）10-1129-05
作者:
 徐伟1; 杨涛1; 解传滨1; 曲宝林1; 曹林2; 王子申2; 宋圆圆2; 方春锋2; 徐寿平1
 1.解放军总医院第一医学中心放疗科， 北京 100853； 2.一洲肿瘤医院放疗科， 河北 涿州 072550
Author(s):
 XU Wei1;  YANG Tao1;  XIE Chuanbin1;  QU Baolin1;  CAO Lin2;  WANG Zishen2;  SONG Yuanyuan2;  FANG Chunfeng2;  XU Shouping1
 1. Department of Radiotherapy, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China; 2. Department of Radiotherapy, Yizhou Cancer Hospital, Zhuozhou 072550, China
关键词:
前列腺癌; 质子放疗; 点扫描技术; 螺旋断层放射治疗; 剂量学
Keywords:
prostate cancer;  proton therapy;  single spot scanning;  helical tomotherapy;  dosimetry
分类号:
R811.1
DOI:
DOI:10.3969/j.issn.1005-202X.2019.10.003
文献标志码:
A
摘要:
 目的：比较前列腺癌质子点扫描技术（SSS-PT）与光子螺旋断层放射治疗（HT）两者之间的剂量学特点，其数据将为临床提供一定的参考。方法：选取12例既往前列腺癌患者作为研究对象，定位后，将CT图像分别传至Raystation和HT计划系统进行放疗计划设计。处方剂量为69 Gy/25 F。比较分析两种放疗计划的靶区适形度指数（CI）、均匀性指数（HI）、靶区和危及器官剂量学参数。结果：靶区的均匀性方面，SSS-PT优于HT（P=0.001）；直肠平均剂量SSS-PT［（21.92±4.00） Gy］低于HT［（31.97±2.60） Gy］（P=0.000）；膀胱平均剂量SSS-PT［（17.62±3.15） Gy］低于HT［（30.52±3.94） Gy］（P=0.000）；对于直肠和膀胱的保护，SSS-PT在低、中剂量区总是优于HT。结论：SSS-PT和HT两种治疗方式在靶区剂量分布均可满足临床需求，在同样靶区覆盖条件下，SSS-PT相较于HT能够更好地保护直肠和膀胱，尤其是在低、中剂量区。
Abstract:
 Abstract: Objective To compare the dosimetric characteristics between single spot scanning of proton therapy (SSS-PT) and helical tomotherapy (HT) for prostate cancer, so as to provide some reference for clinical practice. Methods Twelve patients with the previous history of prostate cancer were enrolled as subjects. After positioning, CT images were transferred into Raystation and HT planning systems for radiotherapy planning. The prescription dose was 69 Gy/25 F. The conformity index and homogeneity index of target areas and the dosimetric parameters of target areas and organs-at-risk in two radiotherapy schemes were compared. Results SSS-PT was superior to HT in the homogeneity index of target areas (P=0.001). Compared with HT, SSS-PT had lower mean doses to rectum ［(21.92±4.00) Gy vs (31.97±2.60) Gy, P=0.000］ and bladder ［(17.62±3.15) Gy vs (30.52±3.94) Gy, P=0.000］. For the sparing of rectum and bladder, SSS-PT was always better than HT in the low- and medium-dose regions. Conclusion Both SSS-PT and HT can satisfy the clinical requirement of target coverage. For the same target coverage, SSS-PT is superior to HT in the sparing of rectum and bladder, especially in the low- and medium-dose regions.

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备注/Memo

备注/Memo:
 【收稿日期】2019-06-11
【基金项目】国家重点研发计划（2017YFC0112100）
【作者简介】徐伟，工程师，研究方向：医学物理及立体定向放射治疗，E-mail: xuwei86520@163.com
【通信作者】徐寿平，高级工程师，研究方向：光子、质子调强放疗和自适应放疗，E-mail: xshp228@163.com
更新日期/Last Update: 2019-10-29