[1]方春锋,解传滨,徐寿平,等.不同铅门模式下高危分期前列腺癌螺旋断层放射治疗剂量学比较[J].中国医学物理学杂志,2020,37(2):138-144.[doi:DOI:10.3969/j.issn.1005-202X.2020.02.002]
 FANG Chunfeng,XIE Chuanbin,et al.Dosimetric study of helical tomotherapy for high-risk prostate cancer under different jaw modes[J].Chinese Journal of Medical Physics,2020,37(2):138-144.[doi:DOI:10.3969/j.issn.1005-202X.2020.02.002]
点击复制

不同铅门模式下高危分期前列腺癌螺旋断层放射治疗剂量学比较()
分享到:

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第2期
页码:
138-144
栏目:
医学放射物理
出版日期:
2020-02-25

文章信息/Info

Title:
Dosimetric study of helical tomotherapy for high-risk prostate cancer under different jaw modes
文章编号:
1005-202X(2020)02-0138-07
作者:
方春锋12解传滨1徐寿平1戴相昆1徐伟1宋圆源2王子申2
1.中国人民解放军总医院第一医学中心放疗科, 北京 100853; 2.河北一洲肿瘤医院放疗科, 河北 涿州 072750
Author(s):
FANG Chunfeng1 2 XIE Chuanbin1 XU Shouping1 DAI Xiangkun1 XU Wei1 SONG Yuanyuan2 WANG Zishen2
1. Department of Radiation Oncology, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China; 2. Department of Radiation Oncology, Hebei Yizhou Cancer Hospital, Zhuozhou 072750, China
关键词:
前列腺癌高危分期螺旋断层放射治疗铅门模式剂量学
Keywords:
Keywords: prostate cancer high-risk stage helical tomotherapy jaw mode dosimetry
分类号:
R737.25;R312
DOI:
DOI:10.3969/j.issn.1005-202X.2020.02.002
文献标志码:
A
摘要:
【摘要】目的:探讨高危分期前列腺癌行螺旋断层局部照射同步盆腔淋巴结照射时,不同铅门模式下(静态和动态)靶区及危及器官的剂量学特点。方法:选取8例需行局部照射同步盆腔淋巴结照射的高危分期前列腺癌患者,分别设计铅门宽度为1.050、2.512和5.050 cm的3组静态铅门计划(F1.050、F2.512、F5.050)以及宽度为2.512、5.050 cm的2组动态铅门计划(D2.512、D5.050)。比较不同计划设计下靶区及危及器官的剂量分布、剂量体积直方图以及出束时间和机器跳数等。结果:在不同铅门模式下,靶区剂量学差异几乎无统计学意义(P>0.05)。而在膀胱、直肠以及股骨头的剂量学比较上,当铅门宽度相同时,动态铅门计划几乎与静态铅门计划相当;当铅门宽度不同时,静态铅门计划远优于比之大一档宽度的动态铅门计划。在非肿瘤组织的剂量辐射比较上,动态铅门技术均体现出了明显的剂量学优势。在计划实施效率方面,各计划平均机器跳数、平均出束时间均随F5.050、D5.050、F2.512、D2.512、F1.050顺序依次递增。结论:对于需行局部照射同步盆腔淋巴结照射的高危分期前列腺癌患者,动态铅门优势有限且在一定程度上降低了计划的实施效率。
Abstract:
Abstract: Objective To explore the dosimetric characteristics of target areas and organs-at-risk (OAR) in high-risk prostate cancer patients treated with helical tomotherapy for local irradiation combined with pelvic lymph node irradiation under different jaw modes (static state and dynamic state). Methods Eight patients with high-risk prostate cancer scheduled for local irradiation combined with pelvic lymph node irradiation were enrolled in this study. Three groups of static plans with the jaw widths of 1.050, 2.512 and 5.050 cm (F1.050, F2.512 and F5.050) and two groups of dynamic plans with the jaw widths of 2.512 and 5.050 cm (D2.512 and D5.050) were designed for each patient. The dose distributions and dose-volume histograms of target areas and organs-at-risk, delivery time and monitor units were compared among different plans. Results Under different jaw modes, the dosimetric difference of target areas was trivial, without statistical differences (P>0.05). For the dosimetric comparison of rectum, bladder and femur head, with the same jaw width, dynamic jaw plan was almost the same as static jaw plan; however, static jaw plan was obviously superior to dynamic jaw plan with larger jaw width when the jaw width was different. Dynamic jaw technique had obvious dosimetric advantages in the dose to normal tissues. The average monitor units and average delivery time of 5 plans were increased with the order of F5.050, D5.050, F2.512, D2.512 and F1.050. Conclusion For patients with high-risk prostate cancer scheduled for local irradiation and pelvic lymph node irradiation, dynamic jaw mode has limited advantages and reduces the delivery efficiency.

相似文献/References:

[1]董晓庆,胡杰,陆春花,等.前列腺癌图像引导放射治疗精准度评估[J].中国医学物理学杂志,2016,33(7):658.[doi:10.3969/j.issn.1005-202X.2016.07.003]
 [J].Chinese Journal of Medical Physics,2016,33(2):658.[doi:10.3969/j.issn.1005-202X.2016.07.003]
[2]倪千喜,Pei-Fong WONG,张九堂.不同治疗床在调强放射治疗和容积旋转放射治疗中的剂量影响分析[J].中国医学物理学杂志,2016,33(11):1116.[doi:10.3969/j.issn.1005-202X.2016.11.007]
 [J].Chinese Journal of Medical Physics,2016,33(2):1116.[doi:10.3969/j.issn.1005-202X.2016.11.007]
[3]曹洋森,于春山,孙永健,等.Monaco两种优化模式在前列腺癌容积旋转调强中的剂量学比较[J].中国医学物理学杂志,2016,33(11):1126.[doi:10.3969/j.issn.1005-202X.2016.11.009]
 [J].Chinese Journal of Medical Physics,2016,33(2):1126.[doi:10.3969/j.issn.1005-202X.2016.11.009]
[4]鞠孟阳,史玉静,李金凯,等. 直肠内气腔对前列腺癌放疗计划的影响[J].中国医学物理学杂志,2018,35(8):879.[doi:DOI:10.3969/j.issn.1005-202X.2018.08.003]
 JU Mengyang,SHI Yujing,LI Jinkai,et al. Effects of gas cavity in rectum on radiotherapy plan for prostate cancer[J].Chinese Journal of Medical Physics,2018,35(2):879.[doi:DOI:10.3969/j.issn.1005-202X.2018.08.003]
[5]张君席,刘振湘,张平,等. 基于太赫兹光谱和成像的前列腺癌检测[J].中国医学物理学杂志,2019,36(5):556.[doi:DOI:10.3969/j.issn.1005-202X.2019.05.012]
 ZHANG Junxi,LIU Zhenxiang,ZHANG Ping,et al. Detection of prostate cancer based on terahertz spectroscopy and imaging[J].Chinese Journal of Medical Physics,2019,36(2):556.[doi:DOI:10.3969/j.issn.1005-202X.2019.05.012]
[6]张祥斌,李光俊,张英杰,等. 基于形变配准算法评估前列腺癌分次间剂量的可行性研究[J].中国医学物理学杂志,2019,36(9):995.[doi:DOI:10.3969/j.issn.1005-202X.2019.09.001]
 ZHANG Xiangbin,LI Guangjun,ZHANG Yingjie,et al. Feasibility of deformable image registration algorithm for interfractional dose calculation in radiotherapy for prostate cancer[J].Chinese Journal of Medical Physics,2019,36(2):995.[doi:DOI:10.3969/j.issn.1005-202X.2019.09.001]
[7]徐伟,杨涛,解传滨,等. 质子点扫描技术与光子Tomotherapy在前列腺癌应用中的剂量学比较[J].中国医学物理学杂志,2019,36(10):1129.[doi:DOI:10.3969/j.issn.1005-202X.2019.10.003]
 XU Wei,YANG Tao,XIE Chuanbin,et al. Dosimetric comparison between single spot scanning of proton therapy and tomotherapy for prostate cancer[J].Chinese Journal of Medical Physics,2019,36(2):1129.[doi:DOI:10.3969/j.issn.1005-202X.2019.10.003]

备注/Memo

备注/Memo:
【收稿日期】2019-10-12 【基金项目】国家重点研发计划(2017YFC0112105);解放军总医院临床科研扶持基金(2017FC-WJFWZX-04) 【作者简介】方春锋,物理师,研究方向:医学物理,E-mail: xiaofang0520@126.com 【通信作者】解传滨,硕士,副主任技师,物理师,研究方向:医学物理和肿瘤精确放疗,E-mail: xiechuanbin2003@163.com
更新日期/Last Update: 2020-03-03