[1]成坚强,安永伟,陶娜,等.3种宫颈癌近距离放射治疗技术剂量学研究[J].中国医学物理学杂志,2022,39(10):1199-1203.[doi:DOI:10.3969/j.issn.1005-202X.2022.10.003]
 CHENG Jianqiang,AN Yongwei,TAO Na,et al.Dosimetric comparison among 3 kinds of brachytherapy techniques in cervical cancer[J].Chinese Journal of Medical Physics,2022,39(10):1199-1203.[doi:DOI:10.3969/j.issn.1005-202X.2022.10.003]
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3种宫颈癌近距离放射治疗技术剂量学研究()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
39卷
期数:
2022年第10期
页码:
1199-1203
栏目:
医学放射物理
出版日期:
2022-11-02

文章信息/Info

Title:
Dosimetric comparison among 3 kinds of brachytherapy techniques in cervical cancer
文章编号:
1005-202X(2022)10-1199-05
作者:
成坚强安永伟陶娜牛瑞军魏玺仪张春林高力英魏世鸿
甘肃省肿瘤医院放疗科, 甘肃 兰州 730050
Author(s):
CHENG Jianqiang AN Yongwei TAO Na NIU Ruijun WEI Xiyi ZHANG Chunlin GAO Liying WEI Shihong
Department of Radiation Oncology, Gansu Provincial Cancer Hospital, Lanzhou 730050, China
关键词:
宫颈癌近距离治疗3D打印插植治疗
Keywords:
Keywords: cervical cancer brachytherapy 3D printing interstitial treatment
分类号:
R737.33;R816.91
DOI:
DOI:10.3969/j.issn.1005-202X.2022.10.003
文献标志码:
A
摘要:
目的:基于三维后装不同模式近距离治疗方案,分析研究不同技术后装治疗过程中靶区和危及器官(OARs)的物理剂量差异。方法:选取72例宫颈癌患者进行回顾性分析,根据施源器的不同模式分为以下3类:常规三维腔内治疗(ICBT)组、徒手插植(ISBT)组和3D打印阴道塞(3DP-ISBT)组。分析不同组别的OARs受量情况。结果:ISBT组平均4根插植针,3DP-ISBT组平均6根插植针,3D打印阴道塞针数多于徒手插植针数量,差异有统计学意义(P<0.001)。3组两两比较,HR-CTV靶区剂量D90和HR-CTV靶区体积差异均没有统计学意义(P>0.05)。以ICBT组作为对照,膀胱受量(D0.1 cc、D1 cc和D2 cc)ISBT组和3DP-ISBT组均显著低于ICBT组(P<0.01),但是ISBT组和3DP-ISBT组之间差异没有统计学意义(P=0.993)。直肠D0.1 cc、D1 cc和D2 cc 3组之间差异没有统计学意义。以ICBT组作为对照,小肠受量(D0.1 cc、D1 cc和D2 cc)ISBT组和3DP-ISBT组显著低于ICBT组(P<0.01)。ISBT组和3DP-ISBT组比较,小肠D0.1 cc、D1 cc和D2 cc 3DP-ISBT组显著低于ISBT组(P<0.01)。结论:通过分析3种近距离治疗模式的OARs受照剂量情况,ISBT技术相比ICBT技术在保护膀胱和小肠方面有较大的优势,其中3DP-ISBT在膀胱和小肠的保护方面是最优的,在直肠保护方面没有显示出明显优势。
Abstract:
Abstract: Objective To analyze the differences in doses to target areas and organs-at-risk during brachytherapy in different modes. Methods According to the different modes of the applicator, 72 patients with cervical cancer were divided into 3 groups, namely conventional three-dimensional intracavitary brachytherapy (ICBT) group, interstitial brachytherapy (ISBT) group and 3D printing interstitial brachytherapy (3DP-ISBT) group. The doses to organs-at-risk in different groups were analyzed. Results The average number of interstitial needles in 3DP-ISBT group was more than that of ISBT group (6 vs 4, P<0.001). The comparison between any 2 groups showed that there was no significant difference in D90 and target volume of HR-CTV (P>0.05). The D0.1 cc, D1 cc and D2 cc of the bladder in ISBT group and 3DP-ISBT group were significantly lower than those in ICBT group (P<0.01), but the differences between ISBT group and 3DP-ISBT group were trivial (P=0.993). No significant difference was found in the D0.1 cc, D1 cc and D2 cc of the rectum among 3 groups. The D0.1 cc, D1 cc and D2 cc of the small intestine in ISBT group and 3DP-ISBT group were significantly lower than those of ICBT group (P<0.01), and the D0.1 cc, D1 cc and D2 cc of the small intestine in 3DP-ISBT group were significantly lower than those of ISBT group (P<0.01). Conclusion By analyzing the exposure doses to organs-at-risk in 3 brachytherapy modes, ISBT is advantageous over ICBT in sparing of bladder and small intestine. Among them, 3DP-ISBT has the optimal performance in the protection of the bladder and small intestine, but it shows no advantages in rectal sparing.

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备注/Memo

备注/Memo:
【收稿日期】2022-04-15 【基金项目】中华国际医学交流基金会肿瘤精准放疗星火计划(2019-N-11-17);甘肃省科技厅重点研发项目(20YF3FA017) 【作者简介】成坚强,硕士,工程师,物理师,主要从事肿瘤放射物理工作,E-mail: chengjianqzlyy@163.com 【通信作者】魏世鸿,硕士,主任医师,主要从事胸部肿瘤放化综合治疗工作,E-mail: weishihong100@163.com
更新日期/Last Update: 2022-10-27