[1]汤秣雄,李效龙.一种无线闭环迷走神经刺激器及系统[J].中国医学物理学杂志,2022,39(12):1530-1537.[doi:DOI:10.3969/j.issn.1005-202X.2022.12.012]
　TANG Moxiong,LI Xiaolong.Wireless closed-loop vagus nerve stimulator and its system[J].Chinese Journal of Medical Physics,2022,39(12):1530-1537.[doi:DOI:10.3969/j.issn.1005-202X.2022.12.012]
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一种无线闭环迷走神经刺激器及系统()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
39卷
期数:
2022年第12期
页码:
1530-1537
栏目:
医学信号处理与医学仪器
出版日期:
2022-12-25

文章信息/Info

Title:
Wireless closed-loop vagus nerve stimulator and its system
文章编号:
1005-202X（2022）12-1530-08
作者:
汤秣雄; 李效龙
江苏科技大学电子信息学院， 江苏 镇江 212003
Author(s):
TANG Moxiong;  LI Xiaolong
School of Electronic Information, Jiangsu University of Science and Technology, Zhenjiang 212003, China
关键词:
癫痫; 脑电信号; 生物信号前置放大器; 双极性刺激脉冲发生器; 电磁耦合
Keywords:
Keywords: epileptic EEG signal bio-signal preamplifier biphasic stimulation pulse generator electromagnetic coupling
分类号:
R318；TN492
DOI:
DOI:10.3969/j.issn.1005-202X.2022.12.012
文献标志码:
A
摘要:
为了治疗药物难治性癫痫，提出一种无线闭环迷走神经刺激器及系统，包括头戴式头皮脑电记录器、迷走神经刺激器、电磁耦合能量发射器和控制应用App，设计一种可以分离局部场电位和动作电位的生物信号前置放大器，一种刺激脉冲参数可调的迷走神经刺激器，一种电磁耦合能量发射器以及一个控制应用App。使用海岸线参数检测算法判定癫痫脑电信号的产生。测试结果表明，生物信号前置放大器对局部场电位和动作电位的放大增益分别为40和60 dB。迷走神经刺激器接收到来自控制应用App的刺激参数后，可以产生对应参数的双极性刺激脉冲。当发射器发射功率为30 dBm，发射线圈和接收线圈距离2 cm时，电磁耦合能量传输效率最大为15.4%。海岸线参数算法的正检率为88%。
Abstract:
Abstract: A wireless closed-loop vagus nerve stimulator and its system which includes a head-mounted scalp EEG recorder, a vagus nerve stimulator, an electromagnetic coupling energy transmitter and a control App are proposed for the treatment of drug-refractory epilepsy. A bio-signal preamplifier that can separate local field potential and action potential, a vagus nerve stimulator that can generate biphasic stimulation pulses with adjustable parameters, an electromagnetic coupling energy transmitter and a control App are designed. The coastline parameter algorithm is used to detect the generation of epileptic signals. The test results show that the amplification gains of the bio-signal preamplifier for local field potential and action potential are 40 and 60 dB, respectively. The vagus nerve stimulator can generate the corresponding biphasic stimulation pulses after it receives stimulation parameters from the control App. When the transmitter power is 30 dBm and the distance between the transmitter coil and the receiver coil is 2 cm, the maximum electromagnetic coupling energy transmission efficiency reaches 15.4%. The detection accuracy of the coastline parameter algorithm is 88%.

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备注/Memo

备注/Memo:
【收稿日期】2022-08-19 【基金项目】国家自然科学基金（61671221） 【作者简介】汤秣雄，硕士研究生，主要从事生物医疗电子电路与系统研究，E-mail: tmx1213@foxmail.com 【通信作者】李效龙，副教授，研究生导师，主要从事生物医疗电子电路与系统研究，E-mail: lixiaolong@just.edu.cn
更新日期/Last Update: 2022-12-23