[1]兰川胜,程云章,蔡克尧. 肝癌经皮穿刺射频消融治疗中消融边缘的测量与控制[J].中国医学物理学杂志,2018,35(8):972-977.[doi:DOI:10.3969/j.issn.1005-202X.2018.08.020]
　LAN Chuansheng,CHENG Yunzhang,CAI Keyao. Quantitative measurement and real-time control of ablation margins during percutaneous radiofrequency ablation therapy of liver cancer[J].Chinese Journal of Medical Physics,2018,35(8):972-977.[doi:DOI:10.3969/j.issn.1005-202X.2018.08.020]
点击复制

 肝癌经皮穿刺射频消融治疗中消融边缘的测量与控制()
分享到：

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
35卷
期数:
2018年第8期
页码:
972-977
栏目:
医学生物物理
出版日期:
2018-08-20

文章信息/Info

Title:
 Quantitative measurement and real-time control of ablation margins during percutaneous radiofrequency ablation therapy of liver cancer
文章编号:
1005-202X（2018）08-0972-06
作者:
 兰川胜1; 程云章1; 蔡克尧2
 1.上海理工大学医疗器械与食品学院， 上海 200093； 2.上海爱立峰医疗科技有限公司， 上海 200120
Author(s):
 LAN Chuansheng1;  CHENG Yunzhang1;  CAI Keyao2
 1. School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China;2. Shanghai Elephant Medical Technology Company Limited, Shanghai 200120
关键词:
 ; 肝癌; 射频消融; 消融边缘; 图像配准
Keywords:
 ; liver cancer;  radiofrequency ablation;  ablation margin;  image registration
分类号:
R318；R730.56
DOI:
DOI:10.3969/j.issn.1005-202X.2018.08.020
文献标志码:
A
摘要:
 肝癌经皮穿刺射频消融(PRFA)治疗，简化了手术流程，减少了手术对患者的损伤。在射频消融（RFA）治疗过程中，消融范围易出现不均匀情况，即未完全消融肝癌或消融边缘(AM)不足的情况，会提高肝癌复发率。本文对肝癌PRFA治疗中AM的测量与控制展开研究。首先阐述RFA治疗原理及AM的概念，然后对AM的测量方法进行分类，分为二维和三维的测量介绍AM在手术中实时控制的重要性。通过对术中实时控制AM的方法介绍并分析优缺点，提出基于RFA治疗前后的三维重建融合图像的自动精确测量最小AM的方法，达到控制AM实现降低肝癌复发率的目的。最后分析指出在肝癌PRFA术中，AM如何实现精确的测量以及未来发展趋势。
Abstract:
 Percutaneous radiofrequency ablation (PRFA) therapy of liver cancer simplifies the surgical procedure and reduces the injuries caused by surgery. However, during RFA therapy, there may be a non-uniform ablation range, which may lead to an increase in tumor recurrence if liver cancer is not completely ablated or the ablation margin (AM) is insufficient. Herein the measurement and control of AM in RFA of liver cancer are investigated. Firstly, the principle of RFA therapy and the concept of AM are introduced. Then the methods for measuring AM are classified into two-dimensional and three-dimensional measurements, and the importance of real-time control of AM during surgery is evaluated. After introducing the method of real-time control of AM during the surgery and analyzing their advantages and disadvantages, a method of automatically and accurately measuring the minimum AM based on three-dimensional reconstruction fusion image before and after RFA therapy is proposed to achieve the control of AM, thus reducing the recurrence rate of liver cancer. Finally, the methods to achieve accurate measurement of AM in RFA therapy of liver cancer are put forward and the future development of RFA therapy is prospected.

相似文献/References:

[1]林拥华,章宝燕,李新丰,等.肝癌介入治疗中旋转数字减影血管造影三维重建技术的应用价值[J].中国医学物理学杂志,2015,32(06):851.[doi:doi:10.3969/j.issn.1005-202X.2015.06.019]
　[J].Chinese Journal of Medical Physics,2015,32(8):851.[doi:doi:10.3969/j.issn.1005-202X.2015.06.019]
[2]王遥,霍万里,熊壮,等.TACE手术中不同站姿下铅眼镜和铅面罩对医生眼晶状体防护效果的蒙特卡洛模拟比较[J].中国医学物理学杂志,2016,33(6):553.[doi:DOI:10.3969/j.issn.1005-202X.2016.06.003]
　[J].Chinese Journal of Medical Physics,2016,33(8):553.[doi:DOI:10.3969/j.issn.1005-202X.2016.06.003]
[3]张新,谷晓芳,王培臣,等.轻离子束治疗设备注册检验关键技术问题[J].中国医学物理学杂志,2016,33(6):559.[doi:10.3969/j.issn.1005-202X.2016.06.004]
　[J].Chinese Journal of Medical Physics,2016,33(8):559.[doi:10.3969/j.issn.1005-202X.2016.06.004]
[4]江芬芬,王培,康盛伟,等. 热释光剂量片测量肺部肿瘤放疗剂量的方法[J].中国医学物理学杂志,2016,33(6):564.[doi:10.3969/j.issn.1005-202X.2016.06.005]
　[J].Chinese Journal of Medical Physics,2016,33(8):564.[doi:10.3969/j.issn.1005-202X.2016.06.005]
[5]刘洪源,彭威,杨锐,等. 锥形束CT离线校正肺癌摆位误差[J].中国医学物理学杂志,2016,33(6):573.[doi:10.3969/j.issn.1005-202X.2016.06.007]
　[J].Chinese Journal of Medical Physics,2016,33(8):573.[doi:10.3969/j.issn.1005-202X.2016.06.007]
[6]赵彪,潘香,杨毅,等. 右乳癌保乳术后瘤床同步X线和后程电子线补量调强放疗剂量学比较[J].中国医学物理学杂志,2016,33(6):576.[doi:10.3969/j.issn.1005-202X.2016.06.008]
　[J].Chinese Journal of Medical Physics,2016,33(8):576.[doi:10.3969/j.issn.1005-202X.2016.06.008]
[7]邓南,钱建庭,刁现芬,等. 基于宽带检测放疗X-光光声效应仿体实验[J].中国医学物理学杂志,2016,33(9):865.[doi:DOI:10.3969/j.issn.1005-202X.2016.09.001]
　[J].Chinese Journal of Medical Physics,2016,33(8):865.[doi:DOI:10.3969/j.issn.1005-202X.2016.09.001]
[8]张先稳,李军,张西志,等. 宫颈癌术后5野调强放疗4个变量组合的最佳治疗模式的剂量学[J].中国医学物理学杂志,2016,33(9):872.[doi:10.3969/j.issn.1005-202X.2016.09.002]
　[J].Chinese Journal of Medical Physics,2016,33(8):872.[doi:10.3969/j.issn.1005-202X.2016.09.002]
[9]胡健,李承军,徐利明,等. 床面倾斜对剂量验证通过率的影响[J].中国医学物理学杂志,2016,33(9):881.[doi:10.3969/j.issn.1005-202X.2016.09.003]
　[J].Chinese Journal of Medical Physics,2016,33(8):881.[doi:10.3969/j.issn.1005-202X.2016.09.003]
[10]陈亚正,肖明勇,孙春堂,等. 准直器角度对宫颈癌术后VMAT计划的影响[J].中国医学物理学杂志,2016,33(9):885.[doi:10.3969/j.issn.1005-202X.2016.09.004]
　[J].Chinese Journal of Medical Physics,2016,33(8):885.[doi:10.3969/j.issn.1005-202X.2016.09.004]
[11]李柱,乔安意,王翀,等. 超声引导下射频消融术治疗肝癌疗效及预后影响因素分析[J].中国医学物理学杂志,2017,34(10):1058.[doi:DOI:10.3969/j.issn.1005-202X.2017.10.018]
　[J].Chinese Journal of Medical Physics,2017,34(8):1058.[doi:DOI:10.3969/j.issn.1005-202X.2017.10.018]
[12]裴宇. 多层螺旋CT灌注参数评价肝癌经动脉化疗栓塞术后疗效[J].中国医学物理学杂志,2018,35(2):191.[doi:DOI:10.3969/j.issn.1005-202X.2018.02.014]
　PEI Yu. Application of multi-slice spiral CT perfusion parameters in the evaluation of curative effect of TACE for hepatocellular carcinoma[J].Chinese Journal of Medical Physics,2018,35(8):191.[doi:DOI:10.3969/j.issn.1005-202X.2018.02.014]
[13]李雅宁,陆世培,彭应林,等. BodyFIX联合腹压板在肝癌大剂量放射治疗中的应用[J].中国医学物理学杂志,2018,35(3):265.[doi:DOI:10.3969/j.issn.1005-202X.2018.03.004]
　LI Yaning,LU Shipei,PENG Yinglin,et al. Application of BodyFIX combined with abdominal pressure plate in stereotactic body radiotherapy for liver cancer[J].Chinese Journal of Medical Physics,2018,35(8):265.[doi:DOI:10.3969/j.issn.1005-202X.2018.03.004]
[14]朱怡卿,王芳. 脂质体姜黄素联合索拉非尼对人肝癌Huh7细胞的抑制作用[J].中国医学物理学杂志,2018,35(11):1324.[doi:DOI:10.3969/j.issn.1005-202X.2018.11.016]
　ZHU Yiqing,WANG Fang. Inhibitory effects of liposome curcumin combined with sorafenib on human hepatocellular carcinoma Huh7 cells[J].Chinese Journal of Medical Physics,2018,35(8):1324.[doi:DOI:10.3969/j.issn.1005-202X.2018.11.016]
[15]周寨文,王子豫,陈清莲,等. 阿霉素洗脱微球TACE对比传统TACE治疗肝癌的Meta分析[J].中国医学物理学杂志,2019,36(2):239.[doi:DOI:10.3969/j.issn.1005-202X.2019.02.022]
　ZHOU Zhaiwen,WANG Ziyu,CHEN Qinlian,et al. Doxorubicin-eluting beads vs conventional TACE for hepatocellular carcinoma: a Meta-analysis[J].Chinese Journal of Medical Physics,2019,36(8):239.[doi:DOI:10.3969/j.issn.1005-202X.2019.02.022]
[16]章李,彭志毅. 磁共振扩散加权成像表观扩散系数评估肝癌患者TACE疗效[J].中国医学物理学杂志,2019,36(5):575.[doi:DOI:10.3969/j.issn.1005-202X.2019.05.016]
　ZHANG Li,PENG Zhiyi. Application of apparent diffusion coefficient values of magnetic resonance diffusion-weighted imaging to evaluate the therapeutic effect of TACE in patients with liver cancer[J].Chinese Journal of Medical Physics,2019,36(8):575.[doi:DOI:10.3969/j.issn.1005-202X.2019.05.016]

备注/Memo

备注/Memo:
 【收稿日期】2018-03-22
【作者简介】兰川胜，硕士，研究方向：精准医疗科学与工程，E-mail: chuanshenglan@163.com
【通信作者】程云章，教授，博士生导师，研究方向：血流动力学及其临床应用、精准医疗科学与工程、医疗器械大数据应用等，E-mail: cyz2008@usst.edu.cn
更新日期/Last Update: 2018-07-26