[1]周寨文,王子豫,陈清莲,等. 阿霉素洗脱微球TACE对比传统TACE治疗肝癌的Meta分析[J].中国医学物理学杂志,2019,36(2):239-244.[doi:DOI:10.3969/j.issn.1005-202X.2019.02.022]
 ZHOU Zhaiwen,WANG Ziyu,CHEN Qinlian,et al. Doxorubicin-eluting beads vs conventional TACE for hepatocellular carcinoma: a Meta-analysis[J].Chinese Journal of Medical Physics,2019,36(2):239-244.[doi:DOI:10.3969/j.issn.1005-202X.2019.02.022]
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 阿霉素洗脱微球TACE对比传统TACE治疗肝癌的Meta分析()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第2期
页码:
239-244
栏目:
生物材料与力学
出版日期:
2019-02-25

文章信息/Info

Title:
 Doxorubicin-eluting beads vs conventional TACE for hepatocellular carcinoma: a Meta-analysis
文章编号:
1005-202X(2019)02-0239-06
作者:
 周寨文1王子豫23陈清莲23黄俊海3
 1.广州中医药大学第一附属医院放射科, 广东 广州 510405; 2.广州中医药大学第一临床医学院, 广东 广州 510405; 3.广州中医药大学第一附属医院肝胆外科, 广东 广州 510405
Author(s):
 ZHOU Zhaiwen1 WANG Ziyu2 3 CHEN Qinlian2 3 HUANG Junhai3
 1. Department of Radiology, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, China; 2. the First Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou 510405, China; 3. Department of Hepatobiliary Surgery, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, China
关键词:
 肝癌药物洗脱微球TACEMeta分析疗效
Keywords:
 Keywords: hepatocellular carcinoma drug-eluting bead transarterial chemoembolization Meta-analysis therapeutic efficacy
分类号:
R735.7
DOI:
DOI:10.3969/j.issn.1005-202X.2019.02.022
文献标志码:
A
摘要:
 目的:采用Meta分析方法评价和比较阿霉素洗脱微球TACE(DEB-TACE)与传统TACE(C-TACE)治疗肝癌的有效性和安全性。 方法:从PubMed、Web of Science和CKIN 数据库检索DEB-TACE和C-TACE治疗肝癌的文献。分别采用RevMan5.0软件分析肿瘤反应和不良事件,漏斗图分析出版偏倚。 结果:共有13个研究1 325例肝癌患者纳入分析。DEB-TACE组的肿瘤反应率优于C-TACE组 (OR:2.28; 95%CI [1.75, 2.96];P<0.0010)。DEB-TACE 组的不良事件风险低于C-TACE组(RR:0.56;95%CI [0.32, 0.97];P=0.04)。 结论:和C-TACE对比,DEB-TACE治疗肝癌更有效、不良事件风险更低。
Abstract:
 Abstract: Objective To conduct a Meta-analysis for assessing the therapeutic efficacy and safety of doxorubicin-eluting bead transcatheter arterial chemoembolization (DEB-TACE) vs conventional TACE (C-TACE) in the treatment of hepatocellular carcinoma (HCC). Methods The relevant studies on DEB-TACE and C-TACE for HCC were searched from PubMed, Web of Science and CKIN databases. The tumor responds and adverse events in the selected studies were analyzed with RevMan5.0 statistical software. Moreover, publication bias was assessed by a funnel plot. Results Thirteen studies with 1 325 HCC patients were finally included in this analysis. The tumor response to DEB-TACE was better than that to C-TACE (OR: 2.28; 95%CI [1.75, 2.96]; P<0.001 0). The risk of adverse events in DEB-TACE group was also lower than that in C-TACE group (RR: 0.56; 95%CI [0.32, 0.97]; P=0.04). Conclusion Compared with C-TACE, DEB-TACE is more effective and has lower risk of adverse events in the treatment of HCC.

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备注/Memo

备注/Memo:
 【收稿日期】2018-11-13
【基金项目】国家自然科学基金(81873303)
【作者简介】周寨文,主管技师,研究方向:肿瘤影像与介入,E-mail: 898637031@qq.com;王子豫,硕士研究生,研究方向:肝胆肿瘤中西医结合治疗,E-mail: 18995833524@163.com
更新日期/Last Update: 2019-02-26