PEEP parameter setting of non-invasive ventilator for prone position mechanical ventilation in patients with severe acute pancreatitis(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2023年第11期
- Page:
- 1418-1422
- Research Field:
- 医学生物物理
- Publishing date:
Info
- Title:
- PEEP parameter setting of non-invasive ventilator for prone position mechanical ventilation in patients with severe acute pancreatitis
- Author(s):
- YE Meizhen1; WU Biyu2; LIU Chunfang1; QIU Yanyan3; LI Yingyi1
- 1. Department of Gastroenterology, Quanzhou First Hospital (Quanzhou First Hospital Affiliated to Fujian Medical University), Quanzhou 362000, China 2. Department of Nursing, Quanzhou First Hospital (Quanzhou First Hospital Affiliated to Fujian Medical University), Quanzhou 362000, China 3. Department of Infectious Diseases, Quanzhou First Hospital (Quanzhou First Hospital Affiliated to Fujian Medical University), Quanzhou 362000, China
- Keywords:
- Keywords: severe acute pancreatitis mechanical ventilation non-invasive ventilator positive end-expiratory pressure prone position
- PACS:
- R563.8
- DOI:
- DOI:10.3969/j.issn.1005-202X.2023.11.016
- Abstract:
- Abstract: Objective To investigate the effect of non-invasive positive end-expiratory pressure (PEEP) on prone position mechanical ventilation in patients with severe acute pancreatitis (SAP). Methods A total of 120 SAP patients in Quanzhou First Hospital were enrolled. The patients were mechanically ventilated using non-invasive ventilator in prone position, with PEEP≥10 cmH2O in observation group (n=60) and PEEP≤5 cmH2O in control group (n=60). The two groups were compared in terms of incidence of complications, mortality rate, mechanical ventilation, ICU stay and hospital stay, ventilation per minute before and at 72 h after treatment, arterial partial pressure of oxygen (PaO2), heart rate (HR), respiratory rate, arterial partial pressure of carbon dioxide (PaCO2), airway closure pressure and peak airway pressure, pH, mean arterial pressure (MAP), CT severity index (CTSI), and acute physiology and chronic health evaluation scoring system II (APACHE-II) score. Results Compared with control group, observation group had higher ventilation per minute, respiratory rate and PaO2, and lower airway closure pressure, peak airway pressure, PaCO2, CTSI score and APACHE-II score (P<0.05). There was no statistically significant difference in MAP and HR between two groups before and after treatment (P>0.05). Mechanical ventilation, ICU stay, and hospital stay in observation group were shorter than those of control group (P<0.05). The 90-d mortality rate was lower in observation group than in control group (P<0.05). Conclusion Non-invasive prone position mechanical ventilation with PEEP≥10 cmH2O for SAP effectively improves intrapulmonary oxygenation, contributes to a shorter treatment and rehabilitation, and improves patient prognosis.
Last Update: 2023-11-24