Abstract

Info

Title:: Thermal field distribution of pancreatic cancer model treated with magnetic induction hyperthermia

Author(s):: ZHANG Heng; LU Mai; Key Laboratory of Optoelectronic Technology and Intelligent Control of Ministry of Education, Lanzhou Jiaotong University, Lanzhou 730070, China

Keywords:: Keywords: pancreatic ductal adenocarcinoma magnetic fluid hyperthermia finite element analysis magnetic medium

Abstract:: Abstract: The effect of magnetic induction hyperthermia on pancreatic ductal adenocarcinoma (PDAC) is analyzed using a three-dimensional model of human abdomen, pancreas, pancreatic duct and tumor constructed based on real human data, and a Helmholtz coil is used as a hyperthermia device to generate alternating magnetic fields. The simulation results of magnetic field and temperature field of magnetic induction hyperthermia acting on PDAC are obtained after coupling electromagnetic and heat transfer modules in the finite element calculation and analysis software COMSOL. The results reveal that the spatial distribution of the magnetic field in the treatment area is relatively uniform, and that the temperature field distribution can provide the optimal temperature for hyperthermia. When magnetic induction hyperthermia is performed for PDAC, the temperature of the tumor tissue can rise rapidly to over 42 ℃, while the surrounding normal tissue does not heat up remarkably. In addition, the study also confirmes that the factors such as the existence of large blood vessels near the pancreatic ducts and magnetic fluid overflow have trivial effects on the efficacy of hyperthermia treatment. The simulation results can be a reference for the clinical implementation of magnetic induction hyperthermia for PDAC.