Abstract

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Title:: Magnetic resonance 3D-ASL for quantitative assessment of cerebral perfusion characteristics in children with viral encephalitis

Author(s):: CAO Yang1; XIAO Neng2; HU Shiteng1; TANG Qiongmei 1; ZHOU Haijun1; 1. Center of Medical Imaging, Chenzhou First Peoples Hospital, Chenzhou 423000, China 2. Department of Pediatric Neurology, Chenzhou First Peoples Hospital, Chenzhou 423000, China

Keywords:: Keywords: viral encephalitis in children magnetic resonance imaging 3D arterial spin labeling cerebral perfusion

Abstract:: Abstract: Objective To investigate the cerebral perfusion characteristics in children with viral encephalitis using magnetic resonance 3D arterial spin labeling (3D-ASL) imaging. Methods Twenty-five pediatric patients with acute viral encephalitis and 25 age-matched healthy controls were enrolled retrospectively. Each patient was evaluated visually on a pseudo-color map of cerebral blood flow (CBF), and the difference between CBF value of the lesion area and that of control group was analyzed quantitatively for determining the cerebral perfusion characteristics of children with viral encephalitis. Results The perfusions in 25 pediatric patients with viral encephalitis were significantly increased in the acute phase. The CBF and normalized CBF values of the acute lesions were significantly higher than those of control group, and their ROC-AUC values were 0.971 and 0.992, respectively. Nine pediatric patients were re-examined after effective treatment, and it was found that the blood perfusion in the lesion area was decreased with the condition improvement of the disease. Conclusion Viral encephalitis in children has certain characteristic imaging manifestations on 3D-ASL. The lesions demonstrate hyperperfusion in the acute phase, and the perfusion is decreased after patients condition is improving. 3D-ASL can provide a new imaging reference for the diagnosis and follow-up of children with viral encephalitis.