Abstract

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Author(s):: LU Liang1; ZENG Xiaotian1; DONG Guozhao2; SONG Zeyu2; TANG Xiaoying1; 1. School of Life Science, Beijing Institute of Technology, Beijing 100081, China 2. School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China

Keywords:: Keywords: hemodynamic response function functional magnetic resonance imaging brain disease review

Abstract:: Abstract: Hemodynamic response function (HRF) which is a mathematical transfer function between neural activity and functional magnetic resonance imaging (fMRI) is related to neurovascular physiology and carries a lot of information related to brain function and pathology of brain diseases which cant be obtained by traditional fMRI analysis. Herein the advances in HRF are reviewed. A basic introduction to fMRI and HRF is given, mainly focusing on 3 parameters of HRF, namely response height, time-to-peak and full-width at half-max. Then, a deconvolution method to estimate HRF parameters is introduced, and the research status of HRF related to the pathology of brain diseases in recent years is summarized. It is found that HRF is associated with the pathology of brain diseases such as obsessive-compulsive disorder, autism spectrum disorder, post-traumatic stress disorder and brain injuries. Modeling and parameters extraction of HRF can provide more potential neuropathological information. HRF analysis can be used as a window for pathological study of brain diseases and provides a new perspective and method for traditional fMRI analysis.