[1]刘致滨,石锦平,李盈辉,等.独立三维剂量验证在鼻咽癌容积调强放射治疗计划中的应用[J].中国医学物理学杂志,2021,38(11):1359-1364.[doi:DOI:10.3969/j.issn.1005-202X.2021.11.008]
　LIU Zhibin,SHI Jinping,LI Yinghui,et al.Application of independent three-dimensional dose verification for volumetric modulated arc therapy of nasopharyngeal carcinoma[J].Chinese Journal of Medical Physics,2021,38(11):1359-1364.[doi:DOI:10.3969/j.issn.1005-202X.2021.11.008]
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独立三维剂量验证在鼻咽癌容积调强放射治疗计划中的应用()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
38卷
期数:
2021年第11期
页码:
1359-1364
栏目:
医学放射物理
出版日期:
2021-11-26

文章信息/Info

Title:
Application of independent three-dimensional dose verification for volumetric modulated arc therapy of nasopharyngeal carcinoma
文章编号:
1005-202X（2021）11-1359-06
作者:
刘致滨; 石锦平; 李盈辉; 张利文; 谢秋英; 滕建建; 常元智
佛山市第一人民医院（中山大学附属佛山医院）肿瘤放射物理科， 广东 佛山 528000
Author(s):
LIU Zhibin;  SHI Jinping;  LI Yinghui;  ZHANG Liwen;  XIE Qiuying;  TENG Jianjian;  CHANG Yuanzhi
Department of Radiation Physics, the First Peoples Hospital of Foshan (Affiliated Foshan Hospital of Sun Yat-sen University), Foshan 528000, China
关键词:
鼻咽癌; 容积调强; Bland-Altman分析; 受试者工作特征曲线; 最佳阈值
Keywords:
Keywords: nasopharyngeal carcinoma volumetric modulated arc therapy Bland-Altman analysis receiver operating characteristic curve optimal threshold
分类号:
R811.1；R737.33
DOI:
DOI:10.3969/j.issn.1005-202X.2021.11.008
文献标志码:
A
摘要:
目的：探讨独立三维剂量验证在鼻咽癌容积调强放射治疗（VMAT）计划中应用的可行性。方法：选取31例鼻咽癌患者的VMAT计划，采用Bland-Altman统计方法对基于独立三维剂量分布和实测重建三维剂量分布的一致性进行分析，从而论证独立三维剂量验证应用于鼻咽癌VMAT计划中的可行性。根据独立三维剂量验证的DVH图和γ通过率分类绘制出受试者工作特征（ROC）曲线，得到鼻咽癌VMAT计划中独立三维剂量验证的最佳γ通过率阈值。结果：鼻咽癌患者的VMAT计划中，两种验证方法有95.34%的测试点落在一致性界限内，因此两种验证方法之间具有较好的一致性。根据ROC曲线和AUC值，选取结构PTV2参数用于γ通过率评价时效果最好，其最佳阈值为95.41%。结论：独立三维剂量验证可以检验计划系统计算的准确性，快速地对计划进行治疗前的验证。最佳阈值有助于对放疗计划进行筛查，为放疗计划的准确实施提供安全、有效的技术保障。
Abstract:
Abstract: Objective To explore the feasibility of independent three-dimensional dose verification for volumetric modulated arc therapy (VMAT) of nasopharyngeal carcinoma (NPC).?ethods The VMAT plans of 31 NPC patients were selected. Bland-Altman method was used to analyze the consistency between independent three-dimensional dose distribution and measured reconstructed three-dimensional dose distribution, so as to demonstrate the feasibility of independent three-dimensional dose verification for VMAT of NPC. Based on the dose-volume histogram of independent three-dimensional dose verification and the classification of gamma passing rate, receiver operating characteristic (ROC) curve was drawn, and the optimal gamma passing rate threshold of independent three-dimensional dose verification for VMAT of NPC was obtained.?esults For two verification methods for VMAT of NPC, 95.34% of the test points were within the consistency range, indicating there was a good consistency between the two verification methods. According to ROC curve and AUC value, PTV2 was selected as the best evaluation of gamma passing rate in the independent three-dimensional dose verification for VMAT of NPC, and its optimal threshold was 95.41%.?onclusion Independent three-dimensional dose verification can be used as a test of the calculation accuracy of the planning system, and the pretreatment planning can be verified quickly.?he optimal threshold is helpful to screen the radiotherapy plan and provides a safe and effective technical guarantee for the accurate implementation of radiotherapy plan.

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备注/Memo

备注/Memo:
【收稿日期】2021-05-26 【基金项目】佛山市卫健局课题（20190038）；国家重点研发计划（2017YFC0113205）；佛山市“登峰计划”专项资金（2019D009） 【作者简介】刘致滨，硕士，研究方向：放疗计划设计与质量控制，E-mail: lzbin2008@sina.com 【通信作者】石锦平，主任技师，研究方向：肿瘤放射物理学，E-mail: rath55@126.com
更新日期/Last Update: 2021-11-27