[1]王远远.自适应放疗在质子治疗中的应用及研究进展[J].中国医学物理学杂志,2025,42(6):708-711.[doi:DOI:10.3969/j.issn.1005-202X.2025.06.002]
　WANG Yuanyuan,Application and development of adaptive radiotherapy in proton therapy[J].Chinese Journal of Medical Physics,2025,42(6):708-711.[doi:DOI:10.3969/j.issn.1005-202X.2025.06.002]
点击复制

自适应放疗在质子治疗中的应用及研究进展()

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
42
期数:
2025年第6期
页码:
708-711
栏目:
医学放射物理
出版日期:
2025-06-20

文章信息/Info

Title:
Application and development of adaptive radiotherapy in proton therapy
文章编号:
1005-202X（2025）06-0708-04
作者:
王远远1; 2
1.中国科学技术大学附属第一医院离子医学中心（合肥离子医学中心），安徽 合肥 230028；2.中国科学院合肥物质科学研究院，安徽 合肥 230031
Author(s):
WANG Yuanyuan1;  2
1. Hefei Ion Medical Center, the First Affiliated Hospital of University of Science and Technology of China, Hefei 230028, China;2. Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China
关键词:
质子放疗; 自适应; 治疗计划; 肿瘤治疗; 综述
Keywords:
proton therapy;  adaptive radiotherapy;  treatment plan;  tumor treatment;  review
分类号:
R318；R811.1
DOI:
DOI:10.3969/j.issn.1005-202X.2025.06.002
文献标志码:
A
摘要:
随着放射治疗技术的不断发展，放疗工作流程也在不断地完善更新。由于放疗通常需要照射多次，患者在分次治疗的过程中可能会发生解剖结构的变化，这会导致患者接受到的放疗剂量发生变化。相比于常规光子放疗，质子放射治疗对射野路径上密度变化的敏感度更高，微小的解剖结构变化可能会导致显著的剂量扰动，从而影响患者的治疗效果。自适应质子放疗通过监测患者解剖结构的变化，触发放疗计划调整的工作流程，以确保肿瘤靶区接受到规定的处方剂量，同时保证周围正常组织不超过剂量限值。本文综述了自适应放射治疗在质子治疗中的应用与发展，并讨论当前存在的一些挑战和可能的自适应策略，以期为自适应放疗在质子治疗领域的研究和应用提供参考和借鉴。
Abstract:
With the continuous development of radiotherapy technology, the radiotherapy workflow is undergoing continuousrefinements and updates. As radiotherapy typically involves multiple treatment sessions, anatomical changes in patients mayoccur during the course of fractionated treatment, which will lead to variations in the delivered radiation dose. Comparedwith conventional photon therapy, proton therapy is more sensitive to density variations along the radiation field path. Evensmall changes in anatomy can result in significant dose perturbations, potentially affecting treatment outcomes. Adaptiveproton therapy monitors anatomical changes in patients and triggers the adjustment of treatment plans to ensure that thetumor target area receives the prescribed dose while maintaining the dose to surrounding normal tissues within prescribedlimits. The review summaries the application and development of adaptive radiotherapy in proton therapy and discusses thecurrent challenges and potential adaptive strategies, with the aim of offering valuable insights for future research and clinicalapplication of adaptive radiotherapy in adaptive proton therapy.

相似文献/References:

[1]阳露,刘红冬,陈志,等. 基于TOPAS计算的磁场下质子辐射剂量分析[J].中国医学物理学杂志,2017,34(3):217.[doi:10.3969/j.issn.1005-202X.2017.03.001]
　[J].Chinese Journal of Medical Physics,2017,34(6):217.[doi:10.3969/j.issn.1005-202X.2017.03.001]
[2]刘春波,皮一飞,徐遥,等.质子放疗计划解析与传输软件开发[J].中国医学物理学杂志,2018,35(4):373.[doi:DOI:10.3969/j.issn.1005-202X.2018.04.001]
　LIU Chunbo,PI Yifei,XU Yao,et al.Development of proton radiotherapy plan analysis and transmission software[J].Chinese Journal of Medical Physics,2018,35(6):373.[doi:DOI:10.3969/j.issn.1005-202X.2018.04.001]
[3]刘燕茹,石继飞,罗利霞. 一种基于均匀设计原理的自适应克隆选择分子对接构像搜索策略[J].中国医学物理学杂志,2018,35(7):828.[doi:DOI:10.3969/j.issn.1005-202X.2018.07.017]
　LIU Yanru,SHI Jifei,LUO LixiaBaotou Medical College,et al. A molecular docking conformational search strategy of adaptive clonal selection algorithm based on principle of uniform design[J].Chinese Journal of Medical Physics,2018,35(6):828.[doi:DOI:10.3969/j.issn.1005-202X.2018.07.017]
[4]汪金龙,L. Alberto Cruz,刘铮铮,等. 权重适配的布拉格峰展宽方法[J].中国医学物理学杂志,2019,36(1):50.[doi:DOI:10.3969/j.issn.1005-202X.2019.01.010]
　WANG Jinlong,L. ALBERTO Cruz,LIU Zhengzheng,et al. Weight adaption-based spread-out Bragg peak method[J].Chinese Journal of Medical Physics,2019,36(6):50.[doi:DOI:10.3969/j.issn.1005-202X.2019.01.010]
[5]徐伟,杨涛,解传滨,等. 质子点扫描技术与光子Tomotherapy在前列腺癌应用中的剂量学比较[J].中国医学物理学杂志,2019,36(10):1129.[doi:DOI:10.3969/j.issn.1005-202X.2019.10.003]
　XU Wei,YANG Tao,XIE Chuanbin,et al. Dosimetric comparison between single spot scanning of proton therapy and tomotherapy for prostate cancer[J].Chinese Journal of Medical Physics,2019,36(6):1129.[doi:DOI:10.3969/j.issn.1005-202X.2019.10.003]
[6]朱子孚,文斌,吴柔,等.自适应脉搏氧系统设计与实现[J].中国医学物理学杂志,2021,38(8):990.[doi:DOI:10.3969/j.issn.1005-202X.2021.08.014]
　ZHU Zifu,WEN Bin,et al.Design and implementation of adaptive pulse oximetry[J].Chinese Journal of Medical Physics,2021,38(6):990.[doi:DOI:10.3969/j.issn.1005-202X.2021.08.014]
[7]刘志鹏,单超,潘灵婧,等.扫描式质子放疗系统自动化束斑测量与分析方法的设计和应用[J].中国医学物理学杂志,2022,39(10):1217.[doi:DOI:10.3969/j.issn.1005-202X.2022.10.007]
　LIU Zhipeng,SHAN Chao,PAN Lingjing,et al.Design and application of automated spot measurement and analysis method for scanning proton radiation therapy system[J].Chinese Journal of Medical Physics,2022,39(6):1217.[doi:DOI:10.3969/j.issn.1005-202X.2022.10.007]
[8]朱羿戎,陶广红,李晓贞.腹腔镜手术机械臂自适应PID控制方法[J].中国医学物理学杂志,2025,42(10):1393.[doi:DOI:10.3969/j.issn.1005-202X.2025.10.018]
　ZHU Yirong,TAO Guanghong,LI Xiaozhen,et al.Adaptive PID control method for laparoscopic surgical robotic arm[J].Chinese Journal of Medical Physics,2025,42(6):1393.[doi:DOI:10.3969/j.issn.1005-202X.2025.10.018]

备注/Memo

备注/Memo:
【收稿日期】2025-01-10【基金项目】国家自然科学基金青年项目（82202945）；合肥市自然科学基金（202334）【作者简介】王远远，硕士，工程师，研究方向：医学物理，E-mail:wangyuanyuan@himc.org.cn
更新日期/Last Update: 2025-06-30