[1]刘蒙蒙,于洪丽.经颅直流电刺激干预脑卒中的不同模式疗法的仿真对比[J].中国医学物理学杂志,2025,42(4):510-516.[doi:10.3969/j.issn.1005-202X.2025.04.013]
　LIU Mengmeng,YU Hongli.Simulation and comparative study of different modes of transcranial direct current stimulationintervention in stroke[J].Chinese Journal of Medical Physics,2025,42(4):510-516.[doi:10.3969/j.issn.1005-202X.2025.04.013]
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经颅直流电刺激干预脑卒中的不同模式疗法的仿真对比()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
42
期数:
2025年第4期
页码:
510-516
栏目:
医学生物物理
出版日期:
2025-04-20

文章信息/Info

Title:
Simulation and comparative study of different modes of transcranial direct current stimulationintervention in stroke
文章编号:
1005-202X（2025）04-0510-07
作者:
刘蒙蒙 1; 于洪丽 2
1.河北工程大学信息与电气工程学院，河北 邯郸 056038；2.河北工业大学生命科学与健康工程学院，天津 300130
Author(s):
LIU Mengmeng1;  YU Hongli2
1. School of Information and Electrical Engineering, Hebei University of Engineering, Handan 056038, China; 2. School of HealthSciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China
关键词:
经颅直流电刺激; 脑卒中; 真实头模型; 有限元仿真
Keywords:
transcranial direct current stimulation;  stroke;  realistic head model;  finite element simulation
分类号:
R318
DOI:
10.3969/j.issn.1005-202X.2025.04.013
文献标志码:
A
摘要:
目的：分析阳极、阴极和双极经颅直流电刺激（tDCS）下脑卒中患者脑内电流分布情况，为不同模式tDCS应用于脑卒中患者康复治疗提供理论依据。方法：基于MRI数据重建头皮、颅骨、脑脊液和大脑4层头部组织结构，并导入有限元仿真软件结合成真实头模型。然后在大脑模型中构建脑卒中病灶，在头皮模型上构建阳极和阴极电极片模型。最后仿真分析阳极、阴极和双极tDCS在卒中大脑中的有效刺激区域、有效刺激深度和利用率。结果：仿真分析结果发现，阳极tDCS的有效刺激区域最集中、利用率最高，双极tDCS的有效刺激深度最深。此外，不同模式tDCS产生的电流密度峰值都位于病灶区域的边界处，大脑内部的有效刺激区域同样位于病灶位置。结论：tDCS是一种有潜力的脑卒中康复治疗方法，根据仿真结果可见，阳极和双极tDCS对卒中大脑的刺激效果在一定程度上可能优于阴极tDCS。
Abstract:
Objective To analyze the cortical current distribution in stroke patients during anodal, cathodal and bi-hemispherictranscranial direct current stimulation (tDCS) interventions for providing a theoretical basis for the application of differentmodes of tDCS in the rehabilitation of stroke patients. Methods The 4 layers of head tissue structures including scalp, skull,cerebrospinal fluid and brain were reconstructed using MRI data, and assembled into a realistic head model using finiteelement simulation software. Then, the stroke lesion was constructed in the brain model, and the anode and cathodeelectrodes were constructed on the scalp model. Finally, the effective stimulation area, effective stimulation depth, andefficiency of anodal, cathodal and bi-hemispheric tDCS in the brain were simulated and analyzed. Results The results ofsimulation analysis showed that anodal tDCS had the strongest focusability and highest stimulation efficiency, while bipolartDCS had the largest effective stimulation depth. In addition, the peak current densities generated by different modes of tDCSwere all located at the boundary of the lesion area, and the effective stimulation areas inside the brain were also located at thelesion area. Conclusion tDCS is a promising treatment for rehabilitation following stroke. The simulation results indicate thatanodal and bi-hemispheric tDCS may have superior stimulation effects than cathodal tDCS.

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备注/Memo

备注/Memo:
【收稿日期】2024-11-07【基金项目】国家自然科学基金（51877068）；河北省自然科学基金（H2022202081）；天津市科技计划项目（22JCZXJC00070）；河北工程大学创新基金（SJ2401002070）【作者简介】刘蒙蒙，博士，讲师，研究方向：生物医学电磁技术，Email: 1033868064@qq.com【通信作者】于洪丽，博士，教授，研究方向：生物电磁与神经工程，Email: yhlzyn@hebut.edu.cn
更新日期/Last Update: 2025-04-30