[1]黄飞,徐洪涛,雷苑,等.青光眼药物跨角膜输运数学模型及特性分析[J].中国医学物理学杂志,2020,37(11):1453-1458.[doi:DOI:10.3969/j.issn.1005-202X.2020.11.020]
　HUANG Fei,XU Hongtao,LEI Yuan,et al.An analysis on mathematical model of glaucoma drug delivery across cornea and its characteristic[J].Chinese Journal of Medical Physics,2020,37(11):1453-1458.[doi:DOI:10.3969/j.issn.1005-202X.2020.11.020]
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青光眼药物跨角膜输运数学模型及特性分析()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第11期
页码:
1453-1458
栏目:
医学生物物理
出版日期:
2020-12-02

文章信息/Info

Title:
An analysis on mathematical model of glaucoma drug delivery across cornea and its characteristic
文章编号:
1005-202X（2020）11-1453-06
作者:
黄飞1; 徐洪涛1; 雷苑2; 屈治国3
1.上海理工大学能源与动力工程学院， 上海 200093； 2.复旦大学附属眼耳鼻喉科医院， 上海 200031； 3.西安交通大学能源与动力工程学院， 陕西 西安 710049
Author(s):
HUANG Fei1;  XU Hongtao1;  LEI Yuan2;  QU Zhiguo3
1. School of Energy and Power Engineering, University of Shanghai for Science and Technology, Shanghai 200093 China 2. Eye & E.N.T Hospital of Fudan University, Shanghai 200031, China 3. School of Energy and Power Engineering, Xian Jiaotong University, Xian 710049, China
关键词:
毛果芸香碱; 角膜; 药物累积; 给药方式; 数学模型
Keywords:
Keywords: pilocarpine cornea drug accumulation administration mode mathematical model
分类号:
R318
DOI:
DOI:10.3969/j.issn.1005-202X.2020.11.020
文献标志码:
A
摘要:
为研究青光眼药物跨角膜输运特性，首先，通过实验结果修正了基于菲克第二定律的药物输运数学模型，验证了数学模型的可行性。其次，通过对数学模型的求解，分析了眼表给药浓度恒定、眼药膏以及受泪液清除作用的眼药水3种给药方式对药物进入眼球前房输运通量以及累积量的影响。结果表明，提高扩散系数可以缩短药物累积从非稳态阶段进入伪稳态阶段的时间，提高药物累积量；给出了不同给药方式下药物累积规律和后两种给药方式下药物进入眼球前房药物输运通量达到峰值的时间及峰值量。此结果可为建立更加完善的青光眼药物输运数学模型及青光眼药物设计提供理论分析基础。
Abstract:
Abstract: In order to study the characteristics of glaucoma drug delivery across cornea, the research was carried in the following steps: firstly, based on the experiments, the mathematical model of drug delivery based on Ficks second law was modified, and the feasibility of the mathematical model was verified secondly, through the solution of the mathematical model, the effects of three administration modes-drugs with constant composition for ocular surface, ointment, and eye-drops that are subject to tears-on the delivery volume and accumulative volume of drugs flowing in the anterior chamber of the eye were analyzed. The results show that the increase of diffusion coefficient can shorten the time of drug accumulation from the non-steady state to the pseudo-steady state, and increase the volume of drug accumulation. The results also show the rules of drug accumulation under different administration modes, as well as the peak time and peak volume of drug delivery in the anterior chamber of the eye under the latter two administration modes. All these results can provide a theoretical basis for the establishment of a more comprehensive mathematical model of glaucoma drug delivery and the design of glaucoma drugs.

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备注/Memo

备注/Memo:
【收稿日期】2020-05-28 【基金项目】国家自然科学基金面上项目（81371015, 82070959）；国家自然科学基金创新群体（51721004）；美国BrightFocus Foundation（G2018112）；复旦大学附属眼耳鼻喉科医院青年科学家培养计划 【作者简介】黄飞，硕士研究生，主要从事传热传质方向研究，E-mail: hf940913@163.com 【通信作者】徐洪涛，教授，研究方向：工程热物理，E-mail: htxu@usst.edu.cn
更新日期/Last Update: 2020-12-02