[1]魏敏,牛振洋,刘苓苓,等.最小子野宽度对肺癌容积调强弧形治疗计划质量的影响[J].中国医学物理学杂志,2020,37(3):277-281.[doi:DOI:10.3969/j.issn.1005-202X.2020.03.004]
　WEI Min,NIU Zhenyang,LIU Lingling,et al.Effect of minimum segment width on the quality of volumetric modulated arc therapy plan for lung cancer[J].Chinese Journal of Medical Physics,2020,37(3):277-281.[doi:DOI:10.3969/j.issn.1005-202X.2020.03.004]
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最小子野宽度对肺癌容积调强弧形治疗计划质量的影响()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第3期
页码:
277-281
栏目:
医学放射物理
出版日期:
2020-03-25

文章信息/Info

Title:
Effect of minimum segment width on the quality of volumetric modulated arc therapy plan for lung cancer
文章编号:
1005-202X（2020）03-0277-05
作者:
魏敏1; 牛振洋2; 刘苓苓3; 李兵兵3; 费振乐1; 王磊2; 李志杰2
1.安徽医科大学生物医学工程学院， 安徽 合肥 230032； 2. 中国人民解放军联勤保障部队第901医院放疗科， 安徽 合肥 230031； 3.中国科学院合肥肿瘤医院， 安徽 合肥 230031
Author(s):
WEI Min1;  NIU Zhenyang2;  LIU Lingling3;  LI Bingbing3;  FEI Zhenle1;  WANG Lei2;  LI Zhijie2
1. School of Biomedical Engineering, Anhui Medical University, Hefei 230032, China; 2. Department of Radiation Oncology, No.901 Hospital of PLA, Hefei 230031, China; 3. Cancer Hospital, Chinese Academy of Sciences, Hefei 230031, China
关键词:
肺癌; 容积旋转调强; 最小子野宽度; 计划质量
Keywords:
Keywords: lung cancer;  volumetric modulated arc therapy;  minimum segment width;  plan quality
分类号:
R811.1；R734.2
DOI:
DOI:10.3969/j.issn.1005-202X.2020.03.004
文献标志码:
A
摘要:
目的：探讨肺癌容积调强弧形治疗（VMAT）计划中，最小子野宽度对放疗计划质量的影响。方法：选择病理证实为肺癌的患者12例，计划靶区处方剂量为60 Gy/30次。使用Monaco治疗计划系统设计全弧VMAT计划，计算网格为0.3 cm，采用6 MV X射线，每个弧的最大控制点数为200。计算不确定度为1%。最小子野宽度依次选取0.5、0.7、1.0、1.2和1.5 cm。以最小子野宽度为1.0 cm的计划为参考，与其他子野宽度下的计划相比较，分析各剂量学指标随最小子野宽度变化的情况。结果：随着最小子野宽度增大为1.2、1.5 cm时，靶区Dmean、D2变化明显（P?0.05）。相比参考最小子野宽度1.0 cm，最小子野宽度为1.5 cm时，适形度指数变化较大（Z=-2.694, P?0.05）；最小子野宽度为0.5、0.7、1.2和1.5 cm时，靶区覆盖率相差较明显（Z=-2.904、-3.061、-2.747、-2.941, P?0.05）。最小子野宽度1.0 cm时，VMAT计划平均机器跳数为684.4 MU；最小子野宽度为0.5、0.7、1.2、1.5 cm时，计划的平均机器跳数分别为为972.8、763.8、660.1、665.3 MU。控制点数随着最小子野宽度的增大呈降低趋势。结论：利用Monaco系统设计肺癌VMAT计划，最小子野宽度为1.0 cm时VMAT计划的质量更好。通过调整VMAT计划的最小子野宽度可大大降低机器跳数，提高射束的有效使用率，同时提高患者的治疗舒适度。
Abstract:
Abstract: Objective To explore the effect of the minimum segment width on the quality of volumetric modulated arc therapy (VMAT) plan for lung cancer. Methods Twelve patients with pathologically confirmed lung cancer were enrolled in the study. The prescription dose of planning target volume (PTV) was 60 Gy/30 fractions. Monaco treatment planning system was used to design full-arc VMAT plans, with a calculation mesh of 0.3 cm, 6 MV X-rays, and a maximum control points of 200 per arc. The statistical uncertainty of each calculation was 1%. The minimum segment width was selected to be 0.5, 0.7, 1.0, 1.2 and 1.5 cm, respectively. The plan with a minimum segment width of 1.0 cm was taken as a reference plan, and then compared with the other plans for analyzing the variation of dosimetric indexes with the minimum segment width. Results When the minimum segment width was increased to 1.2 and 1.5 cm, the Dmean and D2 of target areas varied significantly (P?0.05). There were statistical differences in the conformity index between the reference plan and the plan with the minimum segment width of 1.5 cm (Z=-2.694, P?0.05), and in the target coverage between the reference plan and the plans with the minimum segment width of 0.5, 0.7, 1.2 and 1.5 cm (Z=-2.904, -3.061, -2.747, -2.941, P?0.05). The average monitor units in the VMAT plan with a minimum segment width of 1.0 cm was 684.4 MU, and that in the other plans with a minimum segment width of 0.5, 0.7, 1.2 and 1.5 cm was 972.8, 763.8, 660.1 and 665.3 MU, respectively. With the increase of minimum segment width, the number of control point was decreased. Conclusion For the lung cancer VMAT plans designed by Monaco planning system, the quality of the VMAT plan with a minimum segment width of 1.0 cm is better. Adjusting the minimum segment width of VMAT plan can not only greatly reduce monitor units and improve delivery efficiency, but also improve the comfort of patients.

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备注/Memo

备注/Memo:
【收稿日期】2019-11-08 【基金项目】安徽省自然科学基金（1808085QA13） 【作者简介】魏敏，硕士，研究方向：医学物理，E-mail: 1006529769@qq.com 【通信作者】费振乐，E-mail: feizhenle@21.cn.com
更新日期/Last Update: 2020-04-02