[1]邓官华,林正茂,陈丽霞,等.机械旋转误差对多发脑转移瘤VMAT计划剂量分布的影响[J].中国医学物理学杂志,2020,37(1):38-43.[doi:DOI:10.3969/j.issn.1005-202X.2020.01.008]
　DENG Guanhua,LIN Zhengmao,CHEN Lixia,et al.Effect of rotational mechanical errors on dose distribution of volumetric modulated arc therapy for multiple intracranial metastases[J].Chinese Journal of Medical Physics,2020,37(1):38-43.[doi:DOI:10.3969/j.issn.1005-202X.2020.01.008]
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机械旋转误差对多发脑转移瘤VMAT计划剂量分布的影响()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第1期
页码:
38-43
栏目:
医学放射物理
出版日期:
2020-01-25

文章信息/Info

Title:
Effect of rotational mechanical errors on dose distribution of volumetric modulated arc therapy for multiple intracranial metastases
文章编号:
1005-202X（2020）01-0038-06
作者:
邓官华1; 林正茂2; 陈丽霞3; 戴鹏1; 张平1; 罗龙辉1; 罗日顺1; 赖名耀1; 山常国1; 黄庆1; 蔡林波1
1.广东三九脑科医院肿瘤综合治疗中心， 广东 广州 510510； 2.中山大学孙逸仙纪念医院， 广东 广州 510120； 3.南方医科大学生物医学工程学院， 广东 广州 510515
Author(s):
DENG Guanhua1;  LIN Zhengmao2;  CHEN Lixia3; DAI Peng1;  ZHANG Ping1;  LUO Longhui1;  LUO Rishun1;  LAI Mingyao1;  SHAN Changguo1;  HUANG Qing1;  CAI Linbo1
1. Department of Oncology, Guangdong Sanjiu Brain Hospital, Guangzhou 510510, China; 2. Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China; 3. School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China
关键词:
多发脑转移瘤; 容积旋转调强; 机械旋转误差; 单中心
Keywords:
Keywords: multiple intracranial metastases;  volumetric modulated arc therapy;  rotational mechanical error;  single isocenter
分类号:
R811.1；R312
DOI:
DOI:10.3969/j.issn.1005-202X.2020.01.008
文献标志码:
A
摘要:
目的：探讨直线加速器的机械旋转误差对单中心多发转移瘤VMAT计划剂量分布的影响。方法：随机选取21例多发脑转移瘤患者，假定患者均采用非共面VMAT放疗计划，分别将治疗床、准直器的角度旋转偏移[±]0.5°、[±]1.0°、[±]1.5°、[±]2.0°，并通过Eclipse 13.6治疗计划系统模拟机械旋转偏移误差在多发脑转移瘤VMAT计划中对剂量分布的影响。记录并分析不同治疗床、准直器角度旋转偏移下靶区的适形度指数（CI）、剂量梯度跌落指数（GI）、剂量均匀性指数（HI）以及危及器官的最大剂量。结果：当治疗床及准直器角度旋转偏移大于0.5°时，靶区的CI、GI（治疗床除外）及HI指数差异具有统计学意义（P<0.05）；危及器官的最大剂量差异无统计学意义（P>0.05）。结论：在设计多发脑转移VMAT计划时应考虑等中心与靶区之间的距离，六维床旋转误差校正阈值为0.5°更为合理。
Abstract:
Abstract: Objective To investigate the effect of rotational mechanical errors of linear accelerator on the dose distribution of single-isocenter volumetric modulated arc therapy (VMAT) for multiple intracranial metastases. Methods A total of 21 patients with multiple intracranial metastases were enrolled in the study. Assuming that patients were treated with non-coplanar VMAT, the treatment couch and collimator angle were shifted by ±0.5°, ±1.0°, ±1.5° and ±2.0°, respectively. Eclipse 13.6 treatment planning system was used to study the effects of the rotational mechanical errors on dose distribution of VMAT for multiple intracranial metastases. With different rotational errors, the conformity index, gradient index and homogeneity index of target areas as well as the maximum dose of organs-at-risk were recorded and analyzed. Results There were significant differences in the conformity index, gradient index (except for couch), and homogeneity index of target areas (P<0.05) when the rotational deviations of treatment couch and collimator angle were greater than 0.5°. No significant difference was found in the maximum dose of organs-at-risk (P>0.05). Conclusion In the planning of VMAT for multiple intracranial metastases, the distance between the isocenter and target areas should be taken into consideration and the reasonable correction threshold for six-dimensional couch rotational errors should be 0.5°.

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备注/Memo

备注/Memo:
【收稿日期】2019-07-14 【基金项目】广东三九脑科医院新技术项目（2017012） 【作者简介】邓官华，硕士，中级职称，研究方向：肿瘤早期发现及放射治疗，E-mail: gh.deng@foxmail.com 【通信作者】蔡林波，硕士，主任医师，研究方向：肿瘤放射治疗及免疫治疗，E-mail: cailinbo999@163.com
更新日期/Last Update: 2020-01-14