[1]黄洋洋,李家兵,田玉龙,等.宫颈癌直线加速器放疗时保卵巢对靶区和危及器官的影响[J].中国医学物理学杂志,2020,37(9):1115-1119.[doi:10.3969/j.issn.1005-202X.2020.09.007]
　HUANG Yangyang,LI Jiabing,TIAN Yulong,et al.Effects of ovaries sparing on planning target volume and organs-at-risk during linearaccelerator radiotherapy for cervical cancer[J].Chinese Journal of Medical Physics,2020,37(9):1115-1119.[doi:10.3969/j.issn.1005-202X.2020.09.007]
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宫颈癌直线加速器放疗时保卵巢对靶区和危及器官的影响()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第9期
页码:
1115-1119
栏目:
医学人工智能
出版日期:
2020-09-25

文章信息/Info

Title:
Effects of ovaries sparing on planning target volume and organs-at-risk during linear accelerator radiotherapy for cervical cancer
文章编号:
1005-202X（2020）09-1115-05
作者:
黄洋洋1; 李家兵1; 田玉龙2; 董胜楠3; 杨军1
1. 郑州大学第二附属医院放疗科，河南郑州450014；2. 郑州大学第五附属医院放疗科，河南郑州450052；3. 南华大学核科学技 术学院，湖南衡阳421001
Author(s):
HUANG Yangyang1;  LI Jiabing1;  TIAN Yulong2;  DONG Shengnan3;  YANG Jun1
1. Department of Radiation Oncology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China 2. Department of Radiation Oncology, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China 3. Institute of Nuclear Science and Technology, University of South China, Hengyang 421001, China
关键词:
宫颈癌; 保卵巢; 放射治疗; 剂量学差异
Keywords:
cervical cancer ovaries sparing radiotherapy dosimetric difference
分类号:
R735.1；R811.1
DOI:
10.3969/j.issn.1005-202X.2020.09.007
文献标志码:
A
摘要:
目的：探究宫颈癌直线加速器放疗时保卵巢对计划靶区和危及器官的剂量学影响。方法：随机选取16例保卵巢宫 颈癌直线加速器放疗患者，基于XiO计划系统为每例患者设计7野均分调强计划，并通过归一使95%计划靶区剂量达到 45 Gy。在除卵巢外其他优化参数相同的情况下，生成保卵巢组和不保卵巢组两组治疗计划，比较两组计划的靶区和危及 器官的剂量学差异。结果：两组计划均满足临床要求。对于计划靶区，保卵巢组与不保卵巢组的适形度指数和均匀性指 数分别为0.708±0.051、0.808±0.056（P<0.05）和0.135±0.023、0.087±0.012（P<0.05），保卵巢组适形度和均匀性显著下降。 对于危及器官，保卵巢组小肠、膀胱、直肠和左股骨头的Dmax均大于不保卵巢组（P<0.05），而Dmean、V45、V40、V30、V20和V10无 统计学差异（P>0.05）；保卵巢组脊髓Dmean、Dmax无统计学差异（P>0.05）。结论：保卵巢显著影响计划靶区的剂量分布，对 危及器官影响甚微。
Abstract:
Objective To explore the dosimetric effects of ovaries sparing in linear accelerator (LA) radiotherapy for cervical cancer on planning target volume (PTV) and organs-at-risk (OAR). Methods Sixteen patients treated with ovaries-sparing LA radiotherapy for cervical cancer were randomly selected, and 7-field IMRT plans were designed for each patient based on XiO treatment planning system. The 95% of PTV receiving 45 Gy irradiation dose was achieved by normalization. With the same optimization parameters except the treatment of ovaries, two groups of treatment plans, namely ovaries-sparing group and no ovaries-sparing group, were generated, and the dosimetric differences of PTV and OAR between two groups were compared. Results Both groups met the clinical requirements. The conformity index (CI) in ovaries-sparing group was significantly lower than that in no ovaries-sparing group (0.708±0.051 vs 0.808±0.056, P<0.05), and the homogeneity index (HI) in ovaries-sparing group was much higher (0.135±0.023 vs 0.087±0.012, P<0.05). For OAR, the Dmax of small intestine, bladder, rectum and left femoral head in ovaries-sparing group was higher than that in no ovaries-sparing group (P<0.05), but there was no significant difference in Dmean, V45, V40, V30, V20 and V10 (P>0.05), and the Dmean and Dmax of spinal cord were similar in two groups, without statistical differences (P>0.05). Conclusion Ovaries sparing significantly affects the dose distribution in PTV, but has trivial dosimetric effects on OAR.

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备注/Memo

备注/Memo:
【收稿日期】2020-03-11 【基金项目】河南省科技发展攻关项目（182102310700） 【作者简介】黄洋洋，非全日硕士在读，研究方向：医学物理，E-mail: 837449353@qq.com 【通信作者】杨军，硕士，助理研究员，研究方向：医学物理，E-mail: 52651263@qq.com
更新日期/Last Update: 2020-09-25