[1]罗居东,马长升,赵睿,等. PET特征改变对非小细胞肺癌放射治疗的预测价值[J].中国医学物理学杂志,2019,36(6):677-681.[doi:DOI:10.3969/j.issn.1005-202X.2019.06.011]
　LUO Judong,MA Changsheng,ZHAO Rui,et al. Predictive value of PET feature change in radiotherapy for non-small cell lung cancer[J].Chinese Journal of Medical Physics,2019,36(6):677-681.[doi:DOI:10.3969/j.issn.1005-202X.2019.06.011]
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 PET特征改变对非小细胞肺癌放射治疗的预测价值()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第6期
页码:
677-681
栏目:
医学影像物理
出版日期:
2019-06-25

文章信息/Info

Title:
 Predictive value of PET feature change in radiotherapy for non-small cell lung cancer
文章编号:
1005-202X（2019）06-0677-05
作者:
 罗居东1; 马长升2; 赵睿3; 马长东4
 1.南京医科大学附属常州市第二人民医院肿瘤科， 江苏 常州 213000； 2.山东大学附属山东省肿瘤医院放疗科， 山东 济南 250117； 3.山东省医学物理与图像处理技术重点实验室/山东师范大学物理与电子学院生物医学研究所， 山东 济南 250014； 4.山东大学齐鲁医院放疗科， 山东 济南 250012
Author(s):
 LUO Judong1;  MA Changsheng2;  ZHAO Rui3;  MA Changdong4
 1. Department of Oncology, the Affiliated Changzhou No.2 People’s Hospital, Nanjing Medical University, Changzhou 213000, China; 2. Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Ji’nan 250117, China; 3. Shandong Province Key Laboratory of Medical Physics and Image Processing Technology, Institute of Biomedical Sciences, School of Physics and Electronics, Shandong Normal University, Ji’nan 250014, China; 4. Department of Radiation Oncology, Qilu Hospital of Shandong University, Ji’nan 250012, China
关键词:
 ; 非小细胞肺癌; 18F-FDG PET; 标准摄取值; 纹理特征
Keywords:
 ; Keywords: non-small cell lung cancer;  18F-FDG PET;  standard uptake value;  texture feature
分类号:
R730.55；R318
DOI:
DOI:10.3969/j.issn.1005-202X.2019.06.011
文献标志码:
A
摘要:
 【摘要】目的：探索18F-FDG PET/CT分子影像代谢特征参数与非小细胞肺癌（NSCLC）放疗近期疗效的关系。筛选早期预测NSCLC放疗近期疗效的有效指标。方法：对21例经病理证实的NSCLC患者进行回顾性研究。所有患者均接受治疗前和治疗后18F-FDG PET/CT扫描。使用Matlab程序重建和分割肿瘤靶区。同时提取患者治疗前后PET/CT图像的4个传统特征，包括最大SUV、最小SUV、平均SUV、SUV峰值，以及5个纹理特征，包括角二阶距、对比度、逆差距、熵和自相关。用Spearman相关系数法分析患者治疗后图像特征变化率与肿瘤体积变化率的相关性。以治疗后1个月肿瘤体积减小≥50%为标准，将患者分为无效组（Group1<50%）和有效组（Group2≥50%）。最后，通过Mann-Whitney U检验确定PET/CT影像特征变化率是否能区分肿瘤治疗疗效。结果：Spearman相关性分析结果表明逆差距（RS 0.557, P=0.009）和最大SUV（RS 0.468, P=0.033）与肿瘤体积变化率有相关性，其它参数无相关性。Mann-Whitney U检验结果表明，逆差距和最大SUV均具有统计学意义。结论：在所选的9个指标中，逆差距和最大SUV具有较好的预测价值，但本研究是回顾性研究，病例数相对较少，所选特征也较少，缺乏前瞻性。
Abstract:
 Abstract: Objective To explore the relationship between the metabolic parameters of 18F-FDG PET/CT molecular imaging and the short-term therapeutic efficacy of radiotherapy for non-small cell lung cancer (NSCLC), and to determine the effective indicators for early predicting the short-term efficacy of NSCLC radiotherapy. Methods A total of 21 cases of histologically confirmed NSCLC were retrospectively investigated. All patients received both pre-treatment and post-treatment 18F-FDG PET/CT scans. Matlab program was used to reconstruct and segment tumor target areas. Meanwhile, 4 traditional features, including maximum standard uptake value (SUV), minimum SUV, mean SUV and SUV kurtosis, and 5 texture features, including the second angular moment, contrast, inverse different moment, entropy and autocorrelation, were extracted from pre-treatment and post-treatment PET images. Spearman coefficient correlation analysis was used to analyze the correlation between the change rate of image features and the change rate of tumor volume after treatment. Based on whether the tumor volume reduction at 1 month after treatment ≥50% or not, the patients were divided into ineffective group (Group1<50%) and effective group (Group2≥50%). Finally, Mann-Whitney U test was used to determine whether the change rate of PET/CT imaging features can be used for differentiating the response of tumor to therapy. Results The results of Spearman correlation analysis showed that inverse different moment (RS 0.557, P=0.009) and maximum SUV (RS 0.468, P=0.033) were correlated with the change rate of tumor volume, but had no correlation with the other parameters. The results of Mann Whitney U test revealed that both inverse different moment and maximum SUV were statistically significant. Conclusion Among the 9 selected indicators, only inverse different moment and maximum SUV have good predictive value. However, the retrospective study lack of prospectiveness because only a small number of cases and few features were investigated. Therefore, it’s only a preliminary study, and further research is still ongoing.

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备注/Memo

备注/Memo:
 【收稿日期】2019-02-05
【基金项目】山东省医药卫生科技发展计划项目（2017WSB20007，2016WS0553）；山东省自然科学基金（ZR2019MH136，ZR2017BA024）
【作者简介】罗居东，博士，副研究员，研究方向：肿瘤放射治疗，E-mail: judongluo@163.com
【通信作者】马长东，博士，工程师，研究方向：肿瘤放射物理，E-mail: machdo@126.com
更新日期/Last Update: 2019-06-25