[1]陈祥,单国平,邵凯南,等. 剂量网格分辨率大小对非小细胞肺癌立体定向放射治疗的剂量学影响[J].中国医学物理学杂志,2019,36(1):6-11.[doi:DOI:10.3969/j.issn.1005-202X.2019.01.002]
　CHEN Xiang,SHAN Guoping,SHAO Kainan,et al. Dosimetric impacts of dose grid resolution on stereotactic body radiotherapy for non-small-cell lung cancer[J].Chinese Journal of Medical Physics,2019,36(1):6-11.[doi:DOI:10.3969/j.issn.1005-202X.2019.01.002]
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 剂量网格分辨率大小对非小细胞肺癌立体定向放射治疗的剂量学影响()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第1期
页码:
6-11
栏目:
医学放射物理
出版日期:
2019-01-25

文章信息/Info

Title:
 Dosimetric impacts of dose grid resolution on stereotactic body radiotherapy for non-small-cell lung cancer
文章编号:
1005-202X（2019）01-0006-06
作者:
 陈祥1; 单国平2; 邵凯南2; 李玉成1; 杨一威2; 李浦2; 王彬冰2; 周剑良1
 1.南华大学核科学技术学院， 湖南 衡阳 421001； 2.浙江省肿瘤医院放射物理室， 浙江 杭州 310022
Author(s):
 CHEN Xiang1;  SHAN Guoping2;  SHAO Kainan2;  LI Yucheng1;  YANG Yiwei2;  LI Pu2;  WANG Binbing2;  ZHOU Jianliang1
 1. School of Nuclear Science and Technology, University of South China, Hengyang 421001, China; 2. Department of Radiotherapy Physics, Zhejiang Cancer Hospital, Hangzhou 310022, China
关键词:
 ; 非小细胞肺癌; 立体定向体部放射治疗; 剂量网格; 分辨率
Keywords:
 ; Keywords: non-small-cell lung cancer;  stereotactic body radiotherapy;  dose grid;  resolution
分类号:
R730.55；R811.1
DOI:
DOI:10.3969/j.issn.1005-202X.2019.01.002
文献标志码:
A
摘要:
 目的：定量分析剂量网格分辨率的大小对非小细胞肺癌（NSCLC）立体定向放射治疗（SBRT）计划剂量分布的影响，指导临床选用合适的剂量网格分辨率用于肺癌SBRT计划设计。 方法：选取10例NSCLC患者，采用容积旋转调强技术，使用0.20 cm的剂量网格分辨率设计SBRT计划，将治疗计划结果再分别用0.40、0.30、0.25、0.15、0.10 cm 的剂量网格分辨率计算最终剂量。比较6种不同剂量网格分辨率下的计划靶区（PTV）：D2%、Dmean、D98%、均匀性指数（HI）、适形度指数（CI）和危及器官：全肺、胸壁、食管、心脏、脊髓、主动脉、气管树等的相关剂量学参数的差异。 结果：与0.20 cm剂量网格分辨率组计划相比较，0.40、0.30、0.25、0.15、0.10 cm剂量网格分辨率计算得到的计划的靶区D2%、Dmean、CI均具有统计学意义（P<0.05）；HI除0.15 cm剂量网格分辨率组以外，均具有统计学意义（P<0.05）。在危及器官受照剂量方面，与0.20 cm剂量网格分辨率组计划相比较，大于0.20 cm（0.40、0.30、0.25 cm）组计划全肺、胸壁、食管、心脏、脊髓、主动脉、气管树等的相关剂量学参数差异均有统计学意义（P<0.05）；小于0.20 cm（0.15、0.10 cm）组计划除全肺[V10]、[V20]、[V12.5]和[V13.5]有影响以外（P<0.05），胸壁、食管、心脏、脊髓、主动脉、气管树等的相关剂量学参数差异较小（P>0.05）。 结论：剂量网格分辨率的大小会影响剂量计算的准确性，在NSCLC患者SBRT计划设计时，建议使用0.20 cm或更小的剂量网格分辨率。
Abstract:
 Abstract: Objective To quantitatively analyze the effects of dose grid resolution on the dose distribution of stereotactic body radiotherapy (SBRT) of non-small-cell lung cancer (NSCLC) for providing guidance in selecting the optimal dose grid resolution for the design of SBRT plan of lung cancer. Methods Ten patients with NSCLC were enrolled in this study. With 0.20 cm dose grid resolution, volumetric modulated arc therapy technology was used to design SBRT plan, and then the dose grid resolution was set to 0.40, 0.30, 0.25, 0.15, 0.10 cm to calculate the final dose. Several dosimetric parameters of planning target volume and organs-at-risk, namely the D2%, Dmean, D98%, homogeneity index, conformity index of planning target areas, and the relevant dosimetric parameters of the whole lung, chest wall, esophagus, heart, spinal cord, aorta, tracheal tree, were compared among 6 SBRT plans with different dose grid resolutions. Results The D2%, Dmean and conformity index in plans with dose grid resolutions of 0.40, 0.30, 0.25, 0.15 and 0.10 cm were statistically different from those in the plans with dose grid resolution of 0.20 cm (P<0.05). Statistical differences were also found in homogeneity index between the plans with dose grid resolution of 0.20 cm and the other plans (P<0.05), except for the plans with dose grid resolution of 0.15 cm. The relevant dosimetric parameters of the whole lung, chest wall, esophagus, heart, spinal cord, aorta and tracheal tree in plans with dose grid resolution larger than 0.2 cm (0.40, 0.30, 0.25 cm) were statistically different from those in plans with dose grid resolution of 0.2 cm (P <0.05). For plans with dose grid resolution less than 0.2 cm (0.15, 0.10 cm) and plans with dose grid resolution of 0.2 cm, significant differences were found in the [V10],[V20],[V12.5]and [V13.5]of the whole lung (P<0.05), not in the relevant dosimetry parameters of chest wall, esophagus, heart, spinal cord, aorta and tracheal tree (P>0.05). Conclusion Dose grid resolution can affect the accuracy of dose calculation. In the design of SBRT plans for NSCLC, dose grid resolution of 0.2 cm or smaller is recommended.

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备注/Memo

备注/Memo:
 【收稿日期】2018-06-11
【基金项目】国家重点研发计划（2017YFC0113200）
【作者简介】陈祥，硕士研究生，研究方向：放射物理治疗，E-mail: 362639186@qq.com
【通信作者】周剑良，教授，博士生导师，E-mail: 13327341099@189.cn
更新日期/Last Update: 2019-01-24