[1]刘礼东,杨振,邱小平,等. 利用Delta4对放疗计划进行剂量体积直方图评价的可行性研究[J].中国医学物理学杂志,2018,35(1):25-30.[doi:DOI:10.3969/j.issn.1005-202X.2018.01.006]
　LIU Lidong,YANG Zhen,QIU Xiaoping,et al. Feasibility of Delta4 for plan evaluation based on dose-volume histogram[J].Chinese Journal of Medical Physics,2018,35(1):25-30.[doi:DOI:10.3969/j.issn.1005-202X.2018.01.006]
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 利用Delta4对放疗计划进行剂量体积直方图评价的可行性研究()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
35卷
期数:
2018年第1期
页码:
25-30
栏目:
医学放射物理
出版日期:
2018-02-07

文章信息/Info

Title:
 Feasibility of Delta4 for plan evaluation based on dose-volume histogram
文章编号:
1005-202X（2018）01-0025-06
作者:
 刘礼东1; 杨振2; 邱小平1; 雷明军2; 曹瑛2; 杨晓喻2; 唐杜2; 左宇浩1
 1.南华大学核科学技术学院， 湖南 衡阳 421000； 2.中南大学湘雅医院肿瘤科， 湖南 长沙 410008
Author(s):
 LIU Lidong1;  YANG Zhen2;  QIU Xiaoping1;  LEI Mingjun2;  CAO Ying2;  YANG Xiaoyu2;  TANG Du2;  ZUO Yuhao1
 1. College of Nuclear Science and Technology, University of South China, Hengyang 421000, China; 2. Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China
关键词:
 ; 宫颈癌; 鼻咽癌; 容积调强; Bland-Altman统计分析; Delta4; 剂量体积直方图; 一致性评价; 可行性分析
Keywords:
 ; cervical cancer;  nasopharyngeal cancer;  volumetric modulated arc therapy;  Bland-Altman statistical analysis;  Delta4;  dose-volume histogram;  agreement evaluation;  feasibility analysis
分类号:
R815
DOI:
DOI:10.3969/j.issn.1005-202X.2018.01.006
文献标志码:
A
摘要:
 【摘 要】 目的：探讨Delta4在放疗计划验证过程中进行剂量体积直方图（DVH）评价的可行性。 方法：将基于日志文件的三维剂量重建方法（利用Mobius FXTM实现）作为参考方法，采用Bland-Altman统计方法对基于Delta4的三维剂量评价方法和参考方法在宫颈癌和鼻咽癌容积调强放疗验证中的一致性进行分析，评价两种方法是否具有互换性，从而论证Delta4用于放疗计划DVH评价的可行性。Bland-Altman一致性分析利用的指标为日志文件重建剂量与Delta4实测剂量的均值和差值、TPS计算剂量和Delta4预测剂量的均值与差值，并以此分别绘制均值-差值散点图，通过观察散点分布区间来判断两种方法的一致性。 结果：在鼻咽癌一致性分析中基于日志文件重建剂量与Delta4实测剂量、TPS计算剂量和Delta4预测剂量分别有99%的测量点和97%的测量点落在均值-差值散点图95%一致性区间内；在宫颈癌一致性分析中基于日志文件重建剂量与Delta4实测剂量、TPS计算剂量和Delta4预测剂量有95%的测量点落在均值-差值散点图95%一致性区间内，落在95%一致性区间外的测量点占比在5%之内。 结论：基于Delta4的三维剂量评价方法和基于日志文件的三维剂量重建方法一致性很好，可以互换，因此使用Delta4对计划进行DVH评价是可行的。
Abstract:
 : Objective To discuss the feasibility of Delta4 for dose-volume histogram (DVH)-based evaluation in plan verification. Methods Taking the three-dimensional (3D) dose reconstruction method based on log files (using Mobius FXTM) as a reference method, we applied Bland-Altman statistical method to analyze the agreement of 3D dose evaluation method based on Delta4 and the reference method in the verification of volumetric modulated arc therapy for cervical cancer and nasopharyngeal cancer (NPC), and to evaluate whether the two methods can be mutually replaced, thus demonstrating the feasibility of Delta4 for the DVH-based evaluation of radiotherapy plan. The indexes used in Bland-Altman agreement analysis included the mean and standard deviation of log files reconstruction dose and Delta4 measured dose, treatment planning system calculated dose and Delta4 planned dose, which were also used to draw the mean-difference scatter plots, respectively. Finally, the agreement of the two methods was determined by the scatter-point distribution interval. Results In the NPC agreement analysis, 99% of measuring points between log files-based reconstructed dose and Delta4 measured dose, and 97% of measuring points between TPS calculated dose and Delta4 planned dose fall within the 95% confidence interval (CI) in mean-difference scatter plots. In the cervical cancer agreement analysis, log files-based reconstructed dose and Delta4 measured dose, TPS calculated dose and Delta4 planned dose had 95% of measuring points within the 95%CI in mean-difference scatter plots, which indicated that the proportion of measurement points outside the 95%CI was within 5%. Conclusion Delta4-based 3D dose evaluation and log files-based 3D dose reconstruction are in a good coincidence and can be mutually replaced. Using Delta4 for DVH-based evaluation is feasible.

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备注/Memo

备注/Memo:
 【收稿日期】2017-07-29
【作者简介】刘礼东，研究生，主要研究方向：医学剂量，E-mail: liulidong1114@163.com
【通信作者】邱小平，E-mail：nh6651@163.com；杨振，E-mail: yangzhen@188.com
更新日期/Last Update: 2018-01-25