[1]梁有腾,余辉,张书旭. 基于3种配准方法的宫颈癌外照射放疗累积剂量研究[J].中国医学物理学杂志,2018,35(2):151-155.[doi:DOI:10.3969/j.issn.1005-202X.2018.02.006]
　LIANG Youteng,YU Hui,ZHANG Shuxu. Accumulated dose in external radiation for cervical cancer based on three registration methods[J].Chinese Journal of Medical Physics,2018,35(2):151-155.[doi:DOI:10.3969/j.issn.1005-202X.2018.02.006]
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 基于3种配准方法的宫颈癌外照射放疗累积剂量研究()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
35卷
期数:
2018年第2期
页码:
151-155
栏目:
医学放射物理
出版日期:
2018-02-08

文章信息/Info

Title:
 Accumulated dose in external radiation for cervical cancer based on three registration methods
文章编号:
1005-202X（2018）02-0151-05
作者:
 梁有腾; 余辉; 张书旭
 广州医科大学附属肿瘤医院放疗中心， 广东 广州 510095
Author(s):
 LIANG Youteng;  YU Hui;  ZHANG Shuxu
 Radiotherapy Center, Cancer Center of Guangzhou Medical University, Guangzhou 510095, China
关键词:
 ; 宫颈癌; 图像形变配准; 外照射放疗; 累积剂量
Keywords:
 ; Keywords: cervical cancer;  deformable image registration;  external radiation;  accumulated dose
分类号:
R730.55
DOI:
DOI:10.3969/j.issn.1005-202X.2018.02.006
文献标志码:
A
摘要:
 目的：拟基于3种配准方法（B样条弹性配准、仿射配准和刚性配准），探讨宫颈癌外照射放疗累积剂量及其差异。 方法：选取2015年1月~2016年2月期间进行了两次放疗定位的10例宫颈癌病例。首先，以第二次扫描的CT图像为参考，采用归一化的互信息（MI）和平均绝对差（MAD）评价3种配准方法（B样条弹性配准、仿射配准和刚性配准）的精度。然后，分别采用上述3种方法，将第一次放疗的IMRT剂量，累积到第二次扫描的CT图像，得到3种配准方法的累积剂量DB、DF和DG，最后，以DB为基准，分别比较DF与DB、DG与DB的差异。 结果：配准精度：本文3种配准方法的MI值分别为1.27±0.02、1.24±0.03和1.24±0.02，MI值越大，精度则越高；MAD值分别为4.93±1.03、6.36±1.59和6.76±1.77，MAD值越小，精度则越高。累积剂量差异：DF与DB、DG与DB的MAD分别64.8±49.7和72.9±47.5，MAD值越小，剂量差异越小。DF与DB、DG与DB在直肠和膀胱的V50偏差较大，但是在本研究所选的DVH参数（直肠和膀胱的D50%、V50，CTV和GTV的D95%、Dmean）均没有统计学差异。 结论：对于不同分次的宫颈癌外照射CT图像进行配准，建议采用三维弹性配准方法，其配准精度较高，能获得较准确的即往放疗总剂量。
Abstract:
 Objective To discuss the accumulated dose in external radiation for cervical cancer with three registration methods, namely B-spline nonrigid registration, affine registration and rigid registration, and compare the differences in accumulated doses. Methods The fractional therapy computed tomography (CT) images of ten cervical cancer patients receiving localizations of radiotherapy twice between January 2015 and February 2016 were analyzed. The second therapy CT images (I2) which were regarded as the reference were registered with the first therapy CT images (I1) by B-spline nonrigid registration, affine registration and rigid registration, respectively. The normalized mutual information (MI) and mean absolute deviation (MAD) were used to evaluate the registration accuracies of different registration methods. And then, the intensity-modulated radiotherapy dose of I1 was accumulated to I2, obtaining the accumulated dose of three registration methods (DB, DF and DG, respectively). Finally, the differences between DF and DB, DG and DB were compared. Results For the registration accuracy, the MI values of three registration methods were 1.27±0.02, 1.24±0.03 and 1.24±0.02, respectively. The larger the MI value was, the higher the accuracy became. The MAD values of three registration methods were 4.93±1.03, 6.36±1.59 and 6.76±1.77, respectively. The smaller the MAD value was, the higher the accuracy became. For the differences of accumulated dose, the MAD between DF and DB, DG and DB was 64.8±49.7 and 72.9±47.5, respectively. Though the deviations between DF and DB, DG and DB reached maximum in the V50 of the rectum and the bladder, no statistical differences were found in dose-volume histogram parameters (the D50% and V50 of the rectum and the bladder, the D95% and Dmean of clinical target volume and gross tumor volume). Conclusion Three-dimensional elastic registration was recommended in the registration for the fractional therapy CT images obtained in external radiation for cervical cancer for it can achieve high registration accuracy and obtain more accurate accumulated doses.

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备注/Memo

备注/Memo:
 【收稿日期】2017-08-22
【基金项目】广东省教育厅特色创新项目（2016KTSCX116）；广州市医药卫生科技一般引导项目（20151A011085）
【作者简介】梁有腾，硕士研究生，主要从事肿瘤放射治疗技术研究，E-mail: 512150089@qq.com
【通信作者】张书旭，博士，教授/主任技师，博士导师，主要从事肿瘤放射物理学和医学图像应用研究，E-mail: gthzsx@163.com
更新日期/Last Update: 2018-01-29