[1]喻娟,侯玉桃.不同放疗方案治疗宫颈癌临床效果及剂量学差异比较[J].中国医学物理学杂志,2022,39(6):671-675.[doi:DOI:10.3969/j.issn.1005-202X.2022.06.003]
　YU Juan,HOU Yutao.Comparison of clinical effects and dosimetric differences of different radiotherapy regimens in the treatment of cervical cancer[J].Chinese Journal of Medical Physics,2022,39(6):671-675.[doi:DOI:10.3969/j.issn.1005-202X.2022.06.003]
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不同放疗方案治疗宫颈癌临床效果及剂量学差异比较()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
39卷
期数:
2022年第6期
页码:
671-675
栏目:
医学放射物理
出版日期:
2022-06-27

文章信息/Info

Title:
Comparison of clinical effects and dosimetric differences of different radiotherapy regimens in the treatment of cervical cancer
文章编号:
1005-202X（2022）06-0671-05
作者:
喻娟1; 侯玉桃2
1.张家界市人民医院肿瘤科， 湖南 张家界 427000； 2.湘南学院附属医院全科医学科， 湖南 郴州 423000
Author(s):
YU Juan1;  HOU Yutao2
1. Department of Oncology, Zhangjiajie Peoples Hospital, Zhangjiajie 427000, China 2. Department of General Medicine, Affiliated Hospital of Xiangnan University, Chenzhou 423000, China
关键词:
宫颈癌; 四野盒式治疗; 调强放射治疗; 剂量学
Keywords:
Keywords: cervical cancer radiotherapy delivered using four-field-box-technique intensity-modulated radiotherapy dosimetry
分类号:
R815
DOI:
DOI:10.3969/j.issn.1005-202X.2022.06.003
文献标志码:
A
摘要:
目的：比较不同放疗方案治疗宫颈癌患者的临床效果及剂量学差异。方法：选取92例宫颈癌患者为研究对象，按放疗方案不同分为对照组（n＝45）和观察组（n＝47），对照组给予四野盒式治疗，观察组给予调强放疗，比较两组远期临床疗效，靶区、危及器官剂量差异及放疗不良反应发生率。结果：观察组3年内总生存率、局部控制率分别为91.48%、95.74%，略高于对照组的88.88%、91.11%，但差异无统计学意义（P>0.05）；观察组计划靶区体积最大剂量、平均剂量和靶区适形度指数高于对照组，计划靶区体积最小剂量、靶区均匀性指数低于对照组，差异有统计学意义（P<0.05）；观察组胃肠道反应、骨髓抑制、腹痛/腹泻、尿频/尿痛、皮肤损伤、下肢水肿、晚期直肠反应、晚期膀胱反应发生率低于对照组（P<0.05）。结论：调强放疗在靶区、危及器官的剂量分布具有显著优势，可降低术后放疗不良反应发生率。
Abstract:
Abstract: Objective To compare the clinical effects and dosimetric differences of different radiotherapy regimens in the treatment of cervical cancer. Methods Ninety-two cervical cancer patients were enrolled as the research subjects, and divided into control group (n=45) and observation group (n=47) according to their radiotherapy regimens. Patients in control group were treated with radiotherapy delivered using four-field-box-technique, while those in observation group were treated with intensity-modulated radiotherapy (IMRT). The long-term therapeutic effects, differences in dose to target areas and organs-at-risk, and incidences of adverse reactions to radiotherapy were compared between two groups. Results The 3-year overall survival rate and local control rate in observation group were 91.48% and 95.74%, which were slightly higher than those in control group (88.88% and 91.11%), without statistical differences (P>0.05). The maximum dose, mean dose and conformity index of planning target area in observation group were higher than those in control group, while the minimum dose and homogeneity index of planning target area were lower than those in control group (P<0.05). The incidences of gastrointestinal reaction, bone marrow suppression, abdominal pain/diarrhea, frequent micturition/dysuria, skindamage, edema of lower limbs, late rectal reaction and late bladder reaction in observation group were lower than those in control group (P<0.05). Conclusion IMRT for corvical cancer is advantageous in the dose distributions of target area and organs-at-risk, and moreover, it can reduce the incidences of adverse reactions to radiotherapy.

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　[J].Chinese Journal of Medical Physics,2015,32(6):534.[doi:10.3969/j.issn.1005-202X.2015.04.018]

备注/Memo

备注/Memo:
【收稿日期】2021-11-04 【基金项目】湖南省教育厅科学研究项目（19A465） 【作者简介】喻娟，副主任医师，研究方向：肿瘤内科，E-mail: yjcg0809@163.com 【通信作者】侯玉桃，E-mail: zhi159086@foxmail.com
更新日期/Last Update: 2022-06-27