[1]刘旭剑,王东来,李增怀,等.MIIGX3硫酸钙骨水泥填充软骨下良性病变刮除后骨缺损的生物力学研究[J].中国医学物理学杂志,2021,38(10):1304-1307.[doi:DOI:10.3969/j.issn.1005-202X.2021.10.022]
　LIU Xujian,WANG Donglai,LI Zenghuai,et al.Biomechanical study of bone defects after curettage of benign subchondral lesions filled with MIIGX3 calcium sulfate bone cement[J].Chinese Journal of Medical Physics,2021,38(10):1304-1307.[doi:DOI:10.3969/j.issn.1005-202X.2021.10.022]
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MIIGX3硫酸钙骨水泥填充软骨下良性病变刮除后骨缺损的生物力学研究()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
38卷
期数:
2021年第10期
页码:
1304-1307
栏目:
生物材料与力学
出版日期:
2021-10-27

文章信息/Info

Title:
Biomechanical study of bone defects after curettage of benign subchondral lesions filled with MIIGX3 calcium sulfate bone cement
文章编号:
1005-202X（2021）10-1304-04
作者:
刘旭剑1; 王东来1; 李增怀1; 冯奇1; 常富军2; 冯建刚1
1.河北医科大学第四医院， 河北 石家庄 050011； 2.中国人民解放军联勤保障部队第980医院， 河北 石家庄 050000
Author(s):
LIU Xujian1;  WANG Donglai1;  LI Zenghuai1;  FENG Qi1;  CHANG Fujun2;  FENG Jiangang1
1. the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China 2. the 980th Hospital of PLA Joint Logistics Support Force, Shijiazhuang 050000, China
关键词:
MIIGX3硫酸钙骨水泥; 软骨下良性病变; 软骨瘤; 股骨; 生物力学
Keywords:
Keywords: MIIGX3 calcium sulfate bone cement benign subchondral lesions chondroma femur biomechanics
分类号:
R318.01；R738.3
DOI:
DOI:10.3969/j.issn.1005-202X.2021.10.022
文献标志码:
A
摘要:
目的：探讨MIIGX3硫酸钙骨水泥填充软骨下良性病变刮除后骨缺损的生物力学特点。方法：选择20例股骨近端骨软骨瘤患者，病变刮除后采用MIIGX3硫酸钙骨水泥填充，X线定期对骨吸收和自体骨替代过程进行观察，于术后6和12个月，确保MIIGX3硫酸钙骨水泥完全吸收并被自体骨替代，采用中心旋转测力机测定术后不同时期患侧下肢生物力学特性。结果：20例患者手术成功，切口一期愈合，MIIGX3完全吸收并被自体骨替代，时间11~13周，平均（12.23±1.22）周；术后12个月巴氏评分高于术后6个月（P<0.05）；术后12个月扭转1.5°时扭转刚度、扭转1.5°时扭矩、荷载800 N时压缩刚度均高于术后6个月，荷载800 N 时压缩位移小于术后6个月，差异均具有统计学意义（P<0.05）。结论：MIIGX3硫酸钙骨水泥填充软骨下良性病变刮除后骨缺损生物力学表现较好，患者术后恢复情况及日常生活活动能力均较满意，适合推广。
Abstract:
Abstract: Objective To investigate the biomechanical characteristics of filling bone defects after curettage of benign subchondral lesions with MIIGX3 calcium sulfate cement. Methods Twenty patients with osteochondroma of the proximal femur were enrolled in the study. After curettage of the lesions, MIIGX3 calcium sulfate bone cement was used to fill the bone defects. The bone absorption and autologous bone replacement were observed by X-ray regularly. At 6 th months and 12 nd months after surgery, it was ensured that MIIGX3 calcium sulfate cement was absorbed completely and replaced by autogenous bone. The biological characteristics of the affected lower limbs of the two groups were measured using a central rotation dynamometer. Results The surgery was performed successfully in 20 patients. The patients recovered stably, and the incision was healed at the first stage. MIIGX3 was absorbed completely and replaced by autologous bone in 11-13 weeks, with an average of (12.23±1.22) weeks. The Barthel index at the 12nd month after surgery was higher than that at the 6th month after surgery (P<0.05) and moreover, compared with those at the 6th month after surgery, the torsional stiffness at 1.5°, the torque at 1.5°, and the compression stiffness at a load of 800 N were all higher at the 12nd month after surgery, but the compressive displacement at a load of 800 N was lower, and the differences were statistically significant (P<0.05). Conclusion Using MIIGX3 calcium sulfate bone cement to fill bone defects after curettage of benign subchondral lesions is suitable for promotion, because it has preferable biomechanical performance, and can achieve satisfactory postoperative recovery and activities of daily living.

备注/Memo

备注/Memo:
【收稿日期】2021-07-04 【基金项目】河北省医学科学研究重点课题（20170759） 【作者简介】刘旭剑，硕士，主治医师，研究方向：骨与软组织肿瘤，E-mail: swsxujian@126.com 【通信作者】冯建刚，硕士，主任医师，研究方向：骨与软组织肿瘤，E-mail: 2006fjg@163.com
更新日期/Last Update: 2021-10-29