[1]刘金娥,沈永奇,梁勋斯,等.不同分割剂量同步推量调强放疗治疗肺癌脑转移瘤的安全性分析[J].中国医学物理学杂志,2021,38(4):422-425.[doi:DOI:10.3969/j.issn.1005-202X.2021.04.005]
　LIU Jine,SHEN Yongqi,LIANG Xunsi,et al.Safety analysis of simultaneous integrated boost intensity-modulated radiotherapy with different fractional doses in lung cancer brain metastases[J].Chinese Journal of Medical Physics,2021,38(4):422-425.[doi:DOI:10.3969/j.issn.1005-202X.2021.04.005]
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不同分割剂量同步推量调强放疗治疗肺癌脑转移瘤的安全性分析()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
38卷
期数:
2021年第4期
页码:
422-425
栏目:
医学放射物理
出版日期:
2021-04-29

文章信息/Info

Title:
Safety analysis of simultaneous integrated boost intensity-modulated radiotherapy with different fractional doses in lung cancer brain metastases
文章编号:
1005-202X（2021）04-0422-04
作者:
刘金娥1; 沈永奇1; 梁勋斯2; 叶建忠3; 谢华东4; 刘文健4; 林锋1; 蒙静敏1
1.广西医科大学附属柳铁中心医院肿瘤科， 广西 柳州 545007； 2.广西壮族自治区龙潭医院胸外科， 广西 柳州 545005； 3.广西壮族自治区龙潭医院肿瘤科， 广西 柳州 545005； 4.广西融水县人民医院肿瘤科， 广西 柳州 545300
Author(s):
LIU Jine1;  SHEN Yongqi1;  LIANG Xunsi2;  YE Jianzhong3;  XIE Huadong4;  LIU Wenjian4;  LIN Feng1;  MENG Jingmin1
1. Department of Oncology, Liutie Central Hospital Affiliated to Guangxi Medical University, Liuzhou 545007, China 2. Department of Thoracic Surgery, Longtan Hospital of Guangxi Zhuang Nationality Autonomous Region, Liuzhou 545005, China 3. Department of Oncology, Longtan Hospital of Guangxi Zhuang Nationality Autonomous Region, Liuzhou 545005, China 4. Department of Oncology, Rongshui County Peoples Hospital, Liuzhou 545300, China
关键词:
肺癌脑转移瘤; 同步推量调强放疗; 分割剂量; 安全性
Keywords:
Keywords: lung cancer brain metastases simultaneous integrated boost intensity-modulated radiotherapy fractional dose safety
分类号:
R816.1
DOI:
DOI:10.3969/j.issn.1005-202X.2021.04.005
文献标志码:
A
摘要:
目的：分析不同分割剂量同步推量调强放疗治疗肺癌脑转移瘤的安全性及生存情况。方法：选取肺癌脑转移瘤患者75例，随机分为3组，均实施同步推量调强放疗，其中A组放疗方案为全脑40 Gy/20f（2.0 Gy/f）+瘤区同步推量46 Gy/20f（2.3 Gy/f），B组方案为全脑40 Gy/20f（2.0 Gy/f）+瘤区同步推量52 Gy/20f（2.6 Gy/f），C组方案为全脑40 Gy/20f（2.0 Gy/f）+瘤区同步推量58 Gy/20f（2.9 Gy/f）。放疗开始后，对3组患者危及器官（眼球、晶体、视神经、脑干）平均剂量及最大剂量和3组患者放疗相关不良反应进行比较。治疗结束后定期复查颅脑MRI评价疗效，观察3组患者1年生存率。结果：A、B、C组危及器官平均剂量及最大剂量差异不显著（P>0.05）；A、B、C组急性放疗不良反应发生率差异不显著（P>0.05），晚期神经系统不良反应发生率亦差异不显著（P>0.05），3级放疗不良反应低于5%，无4级放疗不良反应发生。随访1年，C组生存率高于A、B组（P<0.05）。结论：同步推量调强放疗治疗肺癌脑转移瘤是一种安全有效的方法，随着放疗剂量增加，疗效有增加趋势。
Abstract:
Abstract: Objective To discuss the safety of simultaneous integrated boost intensity-modulated radiotherapy with different fractional doses for lung cancer brain metastases, and to analyze the survival rate. Methods Seventy-five patients with brain metastases from lung cancer were selected and randomly divided into 3 groups, and all of them underwent simultaneous integrated boost intensity-modulated radiotherapy. The radiotherapy regimen was the whole brain 40 Gy/20f (2.0 Gy/f) + simultaneous integrated boost to tumor 46 Gy/20f (2.3 Gy/f) in group A, the whole brain 40 Gy/20f (2.0 Gy/f) + simultaneous integrated boost to tumor 52 Gy/20f (2.6 Gy/f) in group B, and the whole brain 40 Gy/20f (2.0 Gy/f) + simultaneous integrated boost to tumor 58 Gy/20f (2.9 Gy/f) in group C. The mean dose and maximum dose delivered to organs-at-risk (eyeball, lens, optic nerve, brain stem), and radiotherapy-induced adverse reactions were compared among 3 groups. After the completion of treatment, all patients underwent regular craniocerebral MRI for evaluating curative effect, and 1-year survival rate was also analyzed. Results The comparison among 3 groups showed that no significant difference was found in the mean dose and maximum dose delivered to organs-at-risk (P>0.05) and the incidence of acute radiotherapy-induced adverse reactions (P>0.05). Moreover, there was no significant difference in the incidence of late neurological adverse reactions (P>0.05). The incidence of radiotherapy-induced adverse reaction of grade 3 was less than 5%, and no radiotherapy-induced adverse reaction occurred. After 1 year of follow-up, the survival rate of group C was higher than that of group A and group B (P<0.05). Conclusion Simultaneous integrated boost intensity-modulated radiotherapy is a safe and effective method for treating brain metastases of lung cancer. With the increase of radiation dose, the curative effect is enhancing.

相似文献/References:

[1]刘金娥,沈永奇,梁勋斯,等.3种不同分割剂量同步推量调强放疗治疗肺癌脑转移瘤的疗效[J].中国医学物理学杂志,2020,37(12):1498.[doi:DOI:10.3969/j.issn.1005-202X.2020.12.005]
　LIU Jine,SHEN Yongqi,LIANG Xunsi,et al.The therapeutic effect of intensity modulated radiotherapy on brain metastases from lung cancer with simultaneous boost of three different fractionated doses[J].Chinese Journal of Medical Physics,2020,37(4):1498.[doi:DOI:10.3969/j.issn.1005-202X.2020.12.005]

备注/Memo

备注/Memo:
【收稿日期】2020-10-18 【基金项目】广西卫计委科研课题（Z20170026）；白求恩医学科学研究基金（B19174CT）；广西中医药局科研课题（GZZC2019204） 【作者简介】刘金娥，硕士，副主任医师，研究方向：肿瘤放射治疗，E-mail: j544508@qq.com 【通信作者】沈永奇，博士，主任医师，研究方向：肿瘤综合治疗，E-mail: ff200205@foxmail.com
更新日期/Last Update: 2021-04-29