3种不同分割剂量同步推量调强放疗治疗肺癌脑转移瘤的疗效-《中国医学物理学杂志》

文章信息/Info

Title:: The therapeutic effect of intensity modulated radiotherapy on brain metastases from lung cancer with simultaneous boost of three different fractionated doses

作者:: 刘金娥1; 沈永奇1; 梁勋斯2; 叶建忠3; 林德帅1; 黄定仪1; 林锋1; 蒙静敏1; 1.广西医科大学附属柳铁中心医院肿瘤科，广西柳州 545007； 2.广西壮族自治区龙潭医院胸外科，广西柳州 545005； 3.广西壮族自治区龙潭医院肿瘤科，广西柳州 545005

Author(s):: LIU Jine1; SHEN Yongqi1; LIANG Xunsi2; YE Jianzhong3; LIN Deshuai1; HUANG Dingyi1; LIN Feng1; MENG Jingmin1; 1. Department of Oncology, Liutie Central Hospital Affiliated to Guangxi Medical University, Liuzhou 545007, China 2. Department of Thoracic Surgery, Longtan Hospital, Guangxi Zhuang Autonomous Region, Liuzhou 545005, China 3. Department of Oncology, Longtan Hospital, Guangxi Zhuang Autonomous Region, Liuzhou 545005, China

Keywords:: Keywords: fractionated dose synchronous boost intensity modulated radiotherapy brain metastases from lung cancer toxic and side effects survival rate

摘要:: 目的：分析3种不同分割剂量同步推量调强放疗治疗肺癌脑转移瘤的效果。方法：选取75例肺癌脑转移瘤患者进行研究，随机分为3组，每组25例，均实施调强放疗。A组：全脑40 Gy/20f（2.0 Gy/f）+瘤区同步推量46 Gy/20f（2.3 Gy/f），B组：全脑40 Gy/20f（2.0 Gy/f）+瘤区同步推量52 Gy/20f（2.6 Gy/f），C组：全脑40 Gy/20 f（2.0 Gy/f）+瘤区同步推量58 Gy/20 f（2.9 Gy/f）。对比3组治疗效果、毒副反应。结果：治疗1个月后3组的局部控制总有效率比较无统计学差异（P>0.05），C组的中位生存期明显高于A、B组（P<0.05），随访1年，C组的生存率高于A组（P<0.05）；3组的毒副反应比较无统计学差异（P>0.05）。结论：3种不同分割剂量同步推量调强放疗治疗肺癌脑转移瘤均有显著效果，但相比较而言，大剂量治疗效果更为确切。

Abstract:: Objective To analyze the therapeutic effect of intensity modulated radiotherapy on brain metastases from lung cancer with synchronous boost treatments of three different fractionated doses. Methods 75 patients with lung cancer brain metastases was selected and randomly divided into three groups. Each group had 25 cases, and all received intensity modulated radiotherapy. Group A: 40 Gy/20f (2.0 Gy/f) for whole brain and 46 Gy/20f (2.3 Gy/f) of simultaneous boost for tumor area group B: 40 Gy/20f (2.0 Gy/f) for whole brain and 52 Gy/20f (2.6 Gy/f) of simultaneous boost for tumor area group C: 40 Gy/20f (2.0 Gy/f) for whole brain and 58 Gy/20f (2.9 Gy/f) of simultaneous boost for tumor area. Compare the therapeutic effects and toxic and side effects of the three groups. Results After one month of treatment, there was no statistical difference in the total effective rate of local control among the three groups (P>0.05). The median survival time of group C was significantly higher than that of group A and group B (P<0.05). Follow-up for one year showed that the survival rate of group C was higher than that of group A (P<0.05). There was no statistical difference in toxic and side effects among the three groups (P>0.05). Conclusion Intensity modulated radiotherapy with synchronous boosts of three different fractionated doses has significant effects on brain metastases from lung cancer, but comparatively, the therapeutic effect of large doses is more accurate.