[1]郭霜,满江位,姜春倩,等. 低强度脉冲超声的生物物理学效应及相关机制的研究进展[J].中国医学物理学杂志,2019,36(5):605-609.[doi:DOI:10.3969/j.issn.1005-202X.2019.05.022]
　GUO Shuang,MAN Jiangwei,JIANG Chunqian,et al. Progress in biophysical effects of low-intensity pulsed ultrasound and related mechanisms[J].Chinese Journal of Medical Physics,2019,36(5):605-609.[doi:DOI:10.3969/j.issn.1005-202X.2019.05.022]
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 低强度脉冲超声的生物物理学效应及相关机制的研究进展()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第5期
页码:
605-609
栏目:
医学生物物理
出版日期:
2019-05-25

文章信息/Info

Title:
 Progress in biophysical effects of low-intensity pulsed ultrasound and related mechanisms
文章编号:
1005-202X（2019）05-0605-05
作者:
 郭霜1; 满江位1; 姜春倩2; 李选鹏1; 王华彬1; 任小山1; 韩渊明1; 王诚3; 付生军1; 杨立1
 1.兰州大学泌尿外科研究所/兰州大学第二医院泌尿外科/甘肃省泌尿系统疾病临床医学中心/甘肃省泌尿系统疾病研究重点实验室， 甘肃 兰州 730030； 2.兰州大学第二医院儿科， 甘肃 兰州 730030； 3.四川大学华西第二医院病理科， 四川 成都 610041
Author(s):
 GUO Shuang1;  MAN Jiangwei1;  JIANG Chunqian2;  LI Xuanpeng1;  WANG Huabin1;  REN Xiaoshan1;  HAN Yuanming1;  WANG Cheng3;  FU Shengjun1;  YANG Li1
 1. Gansu Key Laboratory of Urinary System Disease Research/Gansu Clinical Medicine Center of Urinary System Disease/Department of Urinary Surgery, Lanzhou University Second Hospital/Institute of Urinary Surgery, Lanzhou University, Lanzhou 730030, China;
2. Department of Paediatrics, Lanzhou University Second Hospital, Lanzhou 730030, China; 3. Department of Pathology, West China Second University Hospital, Sichuan University, Chengdu 610041, China
关键词:
低强度脉冲超声; 空化效应; 生物物理学效应; 生物学机制
Keywords:
Keywords: low-intensity pulsed ultrasound;  cavitation;  biophysical effect;  biological mechanism
分类号:
R35
DOI:
DOI:10.3969/j.issn.1005-202X.2019.05.022
文献标志码:
A
摘要:
 低强度脉冲超声（LIPUS）的能量强度较低（<3 W/cm2）并以脉冲波形式输出，作为一种非侵入性的治疗方法现已逐渐用于临床。LIPUS由于其低强度脉冲输出模式而具有的热效应非常小，主要依靠其非热效应发挥治疗作用。此外，LIPUS相应的分子生物学机制主要包括其相关的信号传导通路、基因表达、血管生成和干细胞分化等。目前，LIPUS的具体机制较复杂，本研究就LIPUS的生物物理学效应及其相关机制作一综述，旨在为LIPUS在更多疾病中的广泛应用提供相应的理论基础和最新的研究进展。
Abstract:
 Abstract: As a non-invasive treatment approach, low-intensity pulsed ultrasound (LIPUS) which has low energy intensity (< 3 W/cm2) and outputs in pulse waves is gradually used in clinic. LIPUS has an insignificant thermal effect due to its low intensity pulse output mode, and the therapeutic effect of LIPUS mainly depends on its non-thermal effect. The corresponding molecular biological mechanisms of LIPUS mainly include related signal transduction pathways, gene expression, angiogenesis and stem cell differentiation. At present, the specific mechanism of LIPUS is very complex. Herein the biophysical effects and mechanisms of LIPUS are reviewed, so as to provide the corresponding theoretical basis and the latest research progress for the widespread application of LIPUS in more diseases.

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[1]宗瑜瑾,路舒宽,万明习.“看清”颅内血管——高分辨率经颅超声诊疗系统[J].中国医学物理学杂志,2016,33(12):1233.[doi:10.3969/j.issn.1005-202X.2016.12.011]
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[2]郭霜,李选鹏,王华彬,等. 低强度脉冲超声治疗的应用进展[J].中国医学物理学杂志,2018,35(8):927.[doi:DOI:10.3969/j.issn.1005-202X.2018.08.012]
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备注/Memo

备注/Memo:
 【收稿日期】2018-12-25
【基金项目】甘肃省自然科学基金（17JR5RA237）
【作者简介】郭霜，硕士，研究方向：泌尿外科，E-mail: guosh16@lzu.edu.cn
【通信作者】杨立，研究方向：泌尿外科，Email: yuze250@163.com
更新日期/Last Update: 2019-05-23