[1]李哲宇,沈逸凡,李任任,等.阿尔茨海默病经胼胝体相连大脑皮质的跨半球功能连接改变模式[J].中国医学物理学杂志,2025,42(11):1434-1444.[doi:DOI:10.3969/j.issn.1005-202X.2025.11.005]
　LI Zheyu,SHEN Yifan,et al.Altered patterns of interhemispheric functional connectivity in the cerebral cortex connected via the corpus callosum in Alzheimers disease[J].Chinese Journal of Medical Physics,2025,42(11):1434-1444.[doi:DOI:10.3969/j.issn.1005-202X.2025.11.005]
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阿尔茨海默病经胼胝体相连大脑皮质的跨半球功能连接改变模式()

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
42
期数:
2025年第11期
页码:
1434-1444
栏目:
医学影像物理
出版日期:
2025-11-28

文章信息/Info

Title:
Altered patterns of interhemispheric functional connectivity in the cerebral cortex connected via the corpus callosum in Alzheimers disease
文章编号:
1005-202X（2025）11-1434-11
作者:
李哲宇1; 2; 沈逸凡1; 2; 李任任3; 4; 潘晨曦3; 4; 张卫3; 4; 徐志豪1; 2; 余秋蓉5; 6; 尹大志7; 8; 范明霞1; 2; 李云霞3; 4; 宁瑞鹏1; 2
1.华东师范大学物理与电子科学学院上海市磁共振重点实验室， 上海 200062； 2.华东师范大学医学磁共振与分子影像技术研究院， 上海 200062； 3.复旦大学附属浦东医院神经内科， 上海 201399； 4.同济大学医学院附属同济医院神经内科， 上海 200092； 5.上海交通大学医学院附属瑞金医院放射科， 上海 200025； 6.上海交通大学医学院医学技术学院， 上海 200025； 7.华东师范大学心理与认知科学学院， 上海 200062； 8.上海市长宁区精神卫生中心， 上海 200335
Author(s):
LI Zheyu1;  2;  SHEN Yifan1;  2;  LI Renren3;  4;  PAN Chenxi3;  4;  ZHANG Wei3;  4;  XU Zhihao1;  2;  YU Qiurong5;  6;  YIN Dazhi7;  8;  FAN Mingxia1;  2;  LI Yunxia3;  4;  NING Ruipeng1;  2
1. Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai 200062, China 2. Institute of Magnetic Resonance and Molecular Imaging in Medicine, East China Normal University, Shanghai 200062, China 3. Department of Neurology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China 4. Department of Neurology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200092, China 5. Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China 6. College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China 7. School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China 8. Shanghai Changning Mental Health Center, Shanghai 200335, China
关键词:
阿尔茨海默症; 轻度认知障碍; 痴呆; 胼胝体; 静息态功能磁共振成像; 功能连接
Keywords:
Keywords: Alzheimers disease mild cognitive impairment dementia corpus callosum resting-state functional magnetic resonance imaging functional connectivity
分类号:
R318；R749.1
DOI:
DOI:10.3969/j.issn.1005-202X.2025.11.005
文献标志码:
A
摘要:
目的：探讨阿尔茨海默病（AD）患者经胼胝体相连大脑皮质的跨半球功能连接（FC）改变以及其与认知功能和日常生活活动能力之间的关系。方法：收集28例阿尔茨海默病痴呆期（d-AD）患者、47例轻度认知障碍期（MCI）患者和37例健康对照者（HC）的静息态功能磁共振成像数据。利用经胼胝体纤维束模板，选取与胼胝体的32个亚区直接相连的32对同源皮质脑区作为感兴趣区，进行跨半球FC分析。进一步对患者组的FC值与其蒙特利尔认知评估基础量表（MoCA-B）评分和日常生活活动能力量表（ADL）评分进行相关分析。结果：MCI组和d-AD组的跨半球非同位脑区存在与HC相比FC显著增高的超连接：MCI组分散出现在额叶、顶叶、颞叶以及枕叶，d-AD组集中出现在中央前后回内。MCI组涉及前额叶和枕叶的超连接在d-AD组表现为显著下降。d-AD组的跨半球同位脑区FC比MCI组下降更加明显。此外，d-AD组中有2条前额叶内跨半球FC与MoCA-B评分相关（双侧额下回眶部之间、左内侧额回与右额中回之间），2条FC与ADL评分相关（双侧枕中回之间、左顶下小叶与右额中回之间）。结论：d-AD和MCI存在不同的跨半球FC改变模式，AD患者的跨半球FC改变是非渐进式的。d-AD患者的跨半球同位和非同位脑区FC与MoCA-B评分和ADL评分的密切关系可为临床神经功能调控干预提供客观依据和参考。
Abstract:
Abstract: Objective To investigate alterations in interhemispheric functional connectivity (FC) in the cerebral cortices connected via the corpus callosum in patients with Alzheimers disease (AD), and to explore their relationships with cognitive function and activities of daily living. Methods Resting-state functional magnetic resonance imaging data were collected from 28 patients with Alzheimers dementia (d-AD), 47 patients with mild cognitive impairment (MCI), and 37 healthy controls (HC). Using a trancallosal tract template, 32 pairs of homologous cortical brain regions directly connected to 32 subregions of the corpus callosum were selected as regions of interest for interhemispheric FC analysis. Further correlation analyses were performed between FC values in patient groups and their scores on the Montreal Cognitive Assessment-Basic (MoCA-B) Scale and the Activities of Daily Living (ADL) Scale. Results Compared with HC group, both MCI and d-AD groups exhibited hyperconnectivity (significantly increased FC) in interhemispheric non-homologous brain regions. Specifically, hyperconnectivity in the MCI group was scattered across the frontal, parietal, temporal, and occipital lobes, while in the d-AD group, it was concentrated within the precentral and postcentral gyri. Notably, hyperconnectivity involving the prefrontal and occipital lobes in the MCI group showed significant declines in the d-AD group. The interhemispheric homologous FC in the d-AD group reduced more significantly than the MCI group. Additionally, in the d-AD group, 2 interhemispheric FC within the prefrontal lobe (between the bilateral orbital parts of the inferior frontal gyrus, and between the left medial frontal gyrus and the right middle frontal gyrus) were correlated with MoCA-B scores, and 2 FC (between the bilateral middle occipital gyri, and between the left inferior parietal lobule and the right middle frontal gyrus) were correlated with ADL scores. Conclusion MCI and d-AD exhibit distinct patterns of interhemispheric FC alterations, and the interhemispheric FC changes in AD patients are non-progressive. The close relationships between interhemispheric homologous/non-homologous FC and MoCA-B/ADL scores in d-AD patients provide an objective basis and reference for clinical neuromodulation.

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备注/Memo

备注/Memo:
【收稿日期】2025-03-20 【基金项目】国家自然科学基金（32271096）；上海市申康医院发展中心临床科技创新兴前沿项目（SHDC12021110）；上海市科委科技创新行动计划（22Y11903500）；上海市卫健委新兴交叉领域研究专项（2022JC018） 【作者简介】李哲宇，硕士研究生，研究方向：磁共振成像及应用，E-mail: 51254700053@stu.ecnu.edu.cn 【通信作者】宁瑞鹏，博士，高级工程师，研究方向：磁共振成像及应用，E-mail: rpning@phy.ecnu.edu.cn；李云霞，博士，教授，主任医师，研究方向：神经认知障碍及脑小血管疾病的机制探索，E-mail: Doctorliyunxia@163.com（宁瑞鹏和李云霞为共同通信作者）
更新日期/Last Update: 2025-12-01