[1]苟亮倩,吴书裕,廖华英,等.螺旋断层放疗、静态调强放疗和容积旋转调强放疗技术在宫颈癌放疗的剂量学对比分析[J].中国医学物理学杂志,2025,42(4):429-434.[doi:10.3969/j.issn.1005-202X.2025.04.002]
 GOU Liangqian,WU Shuyu,LIAO Huaying,et al.Dosimetric comparison of tomotherapy, static IMRT and VMAT techniques in radiotherapy forcervical cancer[J].Chinese Journal of Medical Physics,2025,42(4):429-434.[doi:10.3969/j.issn.1005-202X.2025.04.002]
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螺旋断层放疗、静态调强放疗和容积旋转调强放疗技术在宫颈癌放疗的剂量学对比分析()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
42
期数:
2025年第4期
页码:
429-434
栏目:
医学放射物理
出版日期:
2025-04-20

文章信息/Info

Title:
Dosimetric comparison of tomotherapy, static IMRT and VMAT techniques in radiotherapy forcervical cancer
文章编号:
1005-202X(2025)04-0429-06
作者:
苟亮倩吴书裕廖华英杨玉善张国前余辉王晓慧张书旭
广州医科大学附属肿瘤医院放疗中心,广东 广州 510095
Author(s):
GOU Liangqian WU Shuyu LIAO Huaying YANG Yushan ZHANG Guoqian YU Hui WANG Xiaohui ZHANG Shuxu
Radiotherapy Center, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou 510095, China
关键词:
宫颈癌螺旋断层放疗容积旋转调强放疗静态调强放疗剂量学
Keywords:
cervical cancer tomotherapy volumetric modulated arc therapy static intensity-modulated radiotherapy
dosimetry

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分类号:
R737.33;R811.1
DOI:
10.3969/j.issn.1005-202X.2025.04.002
文献标志码:
A
摘要:
目的: 量化评估静态调强放疗( IMRT )、容积旋转调强放疗( VMAT )和螺旋断层放疗( TOMO 3 种技术在宫颈癌放
疗中的剂量学差异,为临床医生的放疗决策提供数据支持,以优化放疗方案的选择。
方法: 选取 2024 2 ~5 月在广州医
科大学附属肿瘤医院收治的
19 例宫颈癌放疗患者的临床数据,对每个病例制定 IMRT VMAT TOMO 3 种计划,并进行剂
量评估,评估指标包括靶区和危及器官(
OARs )的剂量体积参数、均匀性指数( HI )、适形度指数( CI )及机器出束时间等。
结果: 所有治疗计划靶区均达到临床处方要求。在靶区剂量方面, TOMO 组的 D mean D max 均显著低于 IMRT VMAT 组。
对于
OARs TOMO 组在降低膀胱 D mean 、直肠 D mean D max V 30 V 40 ,以及左、右股骨头 D mean D max V 20 V 30 和骨盆 D mean V 20 V 50
等方面表现出显著优势,与 IMRT VMAT 组相比,差异有统计学意义( P <0.05 )。此外, TOMO 组靶区的 CI 显著高于
IMRT VMAT 组,而 PGTVnd HI 显著低于 IMRT 组,差异均有统计学意义( P <0.05 )。虽然 3 组在 PCTV HI 方面的差异无
统计学意义,但
TOMO 组的表现略优于其他两组。值得注意的是, VMAT 技术治疗时间最短。 结论: 在宫颈癌的不同治
疗模式中,
TOMO 技术显示出在靶区剂量覆盖率、 OARs 的剂量分布、 CI HI 方面优于 IMRT VMAT 技术。 VMAT 治疗
效率最高。


Abstract:
Objective To compare the dosimetric disparities among static intensity-modulated radiotherapy (IMRT),volumetric modulated arc therapy (VMAT), and tomotherapy (TOMO) techniques in cervical cancer radiotherapy forproviding data support for clinical decision-making scheme of radiotherapy. Methods The clinical data of 19 cervical cancerpatients, treated at the Affiliated Cancer Hospital and Institute of Guangzhou Medical University from February to May in2024, were analyzed. Three plans were devised for each case using IMRT, VMAT, and TOMO techniques, followed bydosimetric evaluation in terms of various metrics such as dose volume parameters of the target areas as well as organs-at-risk(OAR), conformity index (CI), homogeneity index (HI), and delivery time. Results All 3 plans met the clinical prescriptionrequirements for the target areas. Compared with static IMRT and VMAT, TOMO had significantly lower Dmean and DmaxofPCTV and PGTVnd. For OAR, TOMO demonstrated significant advantages over IMRT and VMAT in the Dmean of thebladder, the Dmean, Dmax, V30, V40of the rectum, the Dmean, Dmax, V20, V30of left and right femoral heads, and the Dmean, V20, V50ofthe pelvis (P<0.05). In addition, the TOMO group showed significantly higher CI for both PCTV and PGTVnd as comparedwith IMRT and VMAT groups, and lower PGTVnd HI than IMRT group (all P<0.05). Although there was trivial differenceamong 3 groups in term of PCTV HI, TOMO group performed slightly better than the other two groups. Notably, VMATtechnique had the shortest treatment time. Conclusion In various treatment modalities for cervical cancer, TOMO is superior to IMRT and VMAT in terms of target dose coverage, OAR dose distribution, CI, and HI. However, VMAT has the highestefficiency.

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备注/Memo

备注/Memo:
【收稿日期】2024-11-05【基金项目】广州市科技计划项目(2023B03J1295);广东省普通高校特色创新类项目(2024KTSCX122)【作者简介】苟亮倩,硕士研究生,研究方向:肿瘤的精准放疗,E-mail: gouliangqian0304@163.com【通信作者】张书旭,博士,教授,主任技师,博士生导师,E-mail: gthzsx@163.com
更新日期/Last Update: 2025-04-30