[1]吴韦清,卢晓光,郑仁超,等.国内首台迈胜PBS质子治疗系统的束流特性分析[J].中国医学物理学杂志,2024,41(3):282-288.[doi:DOI:10.3969/j.issn.1005-202X.2024.03.003]
　WU Weiqing,LU Xiaoguang,ZHENG Renchao,et al.Analysis of beam characteristics of the first Mevion pencil beam scanning proton therapy system in China[J].Chinese Journal of Medical Physics,2024,41(3):282-288.[doi:DOI:10.3969/j.issn.1005-202X.2024.03.003]
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国内首台迈胜PBS质子治疗系统的束流特性分析()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
41卷
期数:
2024年第3期
页码:
282-288
栏目:
医学放射物理
出版日期:
2024-03-27

文章信息/Info

Title:
Analysis of beam characteristics of the first Mevion pencil beam scanning proton therapy system in China
文章编号:
1005-202X（2024）03-0282-07
作者:
吴韦清; 卢晓光; 郑仁超; 彭知义; 刘飞; 胡广原; 袁响林
华中科技大学同济医学院附属同济医院肿瘤科， 湖北 武汉 430030
Author(s):
WU Weiqing;  LU Xiaoguang;  ZHENG Renchao;  PENG Zhiyi;  LIU Fei;  HU Guangyuan;  YUAN Xianglin
Department of Oncology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
关键词:
笔形束扫描; 质子治疗系统; 束流特性
Keywords:
Keywords: pencil beam scanning proton therapy system beam characteristic
分类号:
R318；R811.1
DOI:
DOI:10.3969/j.issn.1005-202X.2024.03.003
文献标志码:
A
摘要:
目的：介绍并讨论国内第一台迈胜S250i紧凑型笔形束扫描质子治疗系统的束流特性。方法：利用平行板电离室测量输出剂量；利用大半径布拉格峰电离室测量从最高能量227 MeV下降到28 MeV 共19档能量下的积分深度剂量，以表征质子束特性；利用Phoenix平板探测器测量射束中心轴上空气束斑曲线，并测量多点束斑验证输出位置精度；测量自适应多叶光栅叶间泄漏和半影减少效果，以表征其性能。结果：该质子系统被校准为最高能量为227 MeV，（10×10） cm2均匀方野在水下5 cm深度处输出剂量为1 Gy。该系统能够将质子束射程调制到患者体表，原始布拉格峰在所有能量下具有恒定的80%-80%宽度8.6 mm。最高能量射束在空气中等中心处的束斑尺寸约为4 mm，束斑投射位置精度在1 mm以内。自适应多叶光栅对最高能量射束的叶间漏率小于1.5%，并能显著减小射野半影。结论：迈胜S250i质子治疗系统具有独特的设计和束流特性，在布拉格峰形状、束斑大小随能量的变化以及自适应光栅的半影锐化效应上均有体现，在TPS建模和计划设计时需要考虑这些差异，以执行精准质子治疗。
Abstract:
Abstract: Objective To present and discuss beam characteristics of the first Mevion S250i gantry-mounted accelerator pencil beam scanning proton therapy system in China. Methods The output dose was measured using a parallel-plate ionization chamber. The integrated depth dose was measured with a large-radius Bragg peak ionization chamber, covering 19 energy levels ranging from 227 MeV to 28 MeV, to analyze the proton beam characteristics. The spots in the air were measured with Phoenix flat panel detector on the beam central axis, and the precision of the delivery position was verified by measuring the multi-spot beam map. The interleaf leakage and penumbra reduction of adaptive aperture were measured to characterize its performance. Results The proton system was calibrated for a maximum energy of 227 MeV, with a (10×10) cm?uniform field delivering 1 Gy dose at a depth of 5 cm underwater. The system effectively modulated the proton beam range to the patients surface, maintaining a constant 80%-80% Bragg peak width of 8.6 mm at all energy levels. The spot size of the highest energy beam at the isocenter was about 4 mm in the air, and the spot delivery position error was less than 1 mm. The interleaf leakage rate of the adaptive aperture for the highest energy beam was below 1.5%, and the penumbra was significantly reduced. Conclusion Mevion S250i proton therapy system demonstrates unique design and beam characteristics, which is reflected in the Bragg peak shape, spot size variation with energy, and penumbra sharpening of adaptive aperture and these differences should be considered in treatment planning system modeling and planning for precision treatment.

相似文献/References:

[1]刘志鹏,单超,潘灵婧,等.扫描式质子放疗系统自动化束斑测量与分析方法的设计和应用[J].中国医学物理学杂志,2022,39(10):1217.[doi:DOI:10.3969/j.issn.1005-202X.2022.10.007]
　LIU Zhipeng,SHAN Chao,PAN Lingjing,et al.Design and application of automated spot measurement and analysis method for scanning proton radiation therapy system[J].Chinese Journal of Medical Physics,2022,39(3):1217.[doi:DOI:10.3969/j.issn.1005-202X.2022.10.007]
[2]高楠,王宇翔,刘志鹏,等.ProBeam质子治疗系统辐射屏蔽的防护效果[J].中国医学物理学杂志,2022,39(11):1349.[doi:DOI:10.3969/j.issn.1005-202X.2022.11.006]
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[3]郑仁超,卢晓光,吴韦清,等.PBS质子治疗系统快速日检QA方案的应用研究[J].中国医学物理学杂志,2024,41(10):1206.[doi:DOI:10.3969/j.issn.1005-202X.2024.10.003]
　ZHENG Renchao,LU Xiaoguang,WU Weiqing,et al.Application of rapid daily quality assurance for pencil beam scanning proton therapy system[J].Chinese Journal of Medical Physics,2024,41(3):1206.[doi:DOI:10.3969/j.issn.1005-202X.2024.10.003]

备注/Memo

备注/Memo:
【收稿日期】2023-11-18 【基金项目】湖北省科技计划（2023BCB096） 【作者简介】吴韦清，主管技师，研究方向：放射物理学，E-mail: b15802766860@126.com 【通信作者】卢晓光，副主任技师，研究方向：放射物理学，E-mail: luxiaoguang@tjh.tjmu.edu.cn
更新日期/Last Update: 2024-03-27