[1]潘淑豪,汪志.独立验证中剂量差异分布及其与肿瘤类型相关性的初步研究[J].中国医学物理学杂志,2024,41(3):289-293.[doi:DOI:10.3969/j.issn.1005-202X.2024.03.004]
　PAN Shuhao,WANG Zhi.Preliminary study on the distributions of dose differences and their correlations with tumor types in independent verification[J].Chinese Journal of Medical Physics,2024,41(3):289-293.[doi:DOI:10.3969/j.issn.1005-202X.2024.03.004]
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独立验证中剂量差异分布及其与肿瘤类型相关性的初步研究()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
41卷
期数:
2024年第3期
页码:
289-293
栏目:
医学放射物理
出版日期:
2024-03-27

文章信息/Info

Title:
Preliminary study on the distributions of dose differences and their correlations with tumor types in independent verification
文章编号:
1005-202X（2024）03-0289-05
作者:
潘淑豪; 汪志
安徽医科大学第一附属医院肿瘤放疗科， 安徽 合肥 230022
Author(s):
PAN Shuhao;  WANG Zhi
Department of Radiation Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
关键词:
调强放射治疗; 独立剂量验证; 质量控制; 剂量差异
Keywords:
Keywords: intensity-modulated radiotherapy independent dose verification quality assurance dose difference
分类号:
R811.1；R814.2
DOI:
DOI:10.3969/j.issn.1005-202X.2024.03.004
文献标志码:
A
摘要:
目的：对调强放射治疗（IMRT）计划进行分类独立验证，探讨计划剂量差异分布及其与肿瘤类型的相关性，并建立预测模型。方法：收集180例头颈部、胸部及腹部肿瘤患者固定野IMRT计划，采用独立样本t检验对治疗计划系统中初始计算剂量与独立验算剂量进行一致性分析，以评估独立验证的可行性。比较不同肿瘤间计划靶区（PTV）的剂量差异分布。采用相关性分析及多元线性回归方法分析PTV剂量差异与靶区适形度指数（CI）、均匀性指数间相关性。结果：头颈部、胸部及腹部肿瘤PTV剂量差异均在±1.2%以内，初始剂量与验算剂量间3%/3 mm平均γ通过率>99.5%，显示独立验证与治疗计划系统的剂量分布具有良好一致性。头颈部、胸部及腹部计划中PTV剂量差异分布不同，且与CI显著相关。根据CI可在独立验证中初步判断PTV剂量差异，基于CI及均匀性指数的多元回归方程可用于预估IMRT计划的剂量验算差异。结论：独立验证可快速实现放疗计划治疗前验证，提高放疗计划质量控制的效率。基于剂量差异的预估对放疗计划的优化起到一定指导作用。
Abstract:
Abstract: Objective To explore the distributions of dose differences and their correlations with tumor types in independent three-dimensional dose verification for intensity-modulated radiotherapy (IMRT) plan, and to establish prediction models. Methods The fixed field IMRT plans of 180 patients with head and neck, chest, and abdominal tumors were collected. Independent sample t-test was used to analyze the consistency between the initial dose calculated in treatment planning system and the verified dose for evaluating the feasibility of independent validation. The distributions of planning target volume (PTV) dose differences among different tumor types were analyzed. The correlations of PTV dose differences with conformity index (CI) and homogeneity index were analyzed using correlation analysis and multiple linear regression method. Results The PTV dose differences for head and neck, chest, and abdominal tumors were within ±1.2%, and the average 3%/3 mm gamma passing rate between the initial dose and the verified dose was higher than 99.5%, indicating good consistency in dose distribution between independent validation and treatment planning system. The distributions of PTV dose differences were different in head and neck, chest, and abdominal plans, and were significantly correlated with CI which could be used to preliminarily determine the PTV dose differences in independent validation. The multiple regression equation based on CI and homogeneity index could be used to estimate the dose verification differences of IMRT plan. Conclusion Independent verification can quickly achieve pre-treatment validation for radiotherapy plans, improving the efficiency of quality control of radiotherapy plans. The estimation based on dose differences provides guidance for optimizing radiotherapy plans.

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备注/Memo

备注/Memo:
【收稿日期】2023-09-06 【基金项目】安徽高校协同创新项目（GXXT-2022-011） 【作者简介】潘淑豪，博士，工程师，研究方向：肿瘤放射物理，E-mail: haoshu_123@163.com
更新日期/Last Update: 2024-03-27