[1]齐瑜鹏,赵言龙,郑浩然.一种通过代谢差异分析抑制SARS-CoV-2复制的靶点预测方法[J].中国医学物理学杂志,2023,40(12):1577-1584.[doi:DOI:10.3969/j.issn.1005-202X.2023.12.019]
　QI Yupeng,ZHAO Yanlong,ZHENG Haoran.Target prediction approach to inhibit SARS-CoV-2 replication based on metabolic difference analysis[J].Chinese Journal of Medical Physics,2023,40(12):1577-1584.[doi:DOI:10.3969/j.issn.1005-202X.2023.12.019]
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一种通过代谢差异分析抑制SARS-CoV-2复制的靶点预测方法()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
40卷
期数:
2023年第12期
页码:
1577-1584
栏目:
其他（激光医学等）
出版日期:
2023-12-27

文章信息/Info

Title:
Target prediction approach to inhibit SARS-CoV-2 replication based on metabolic difference analysis
文章编号:
1005-202X（2023）12-1577-08
作者:
齐瑜鹏; 赵言龙; 郑浩然
中国科学技术大学计算机科学与技术学院， 安徽 合肥 230027
Author(s):
QI Yupeng;  ZHAO Yanlong;  ZHENG Haoran
School of Computer Science and Technology, University of Science and Technology of China, Hefei 230027, China
关键词:
COVID-19; SARS-CoV-2; 代谢差异分析; 靶点预测
Keywords:
Keywords: COVID-19 SARS-CoV-2 metabolic difference analysis target prediction
分类号:
R318
DOI:
DOI:10.3969/j.issn.1005-202X.2023.12.019
文献标志码:
A
摘要:
提出一种通过代谢差异分析抑制新型冠状病毒（SARS-CoV-2）复制进程的靶点预测方法。该方法基于肺宿主细胞的基因表达数据，重建病毒入侵后宿主细胞代谢系统发生变化的部分网络模型，并通过单基因敲除和细胞毒性测试识别候选靶点。此外，分析抗病毒靶点对目前已知的多种SARS-CoV-2变体的稳健性。结果表明，D-丙氨酸是影响SARS-CoV-2复制的关键代谢物，且适用于当前所有的SARS-CoV-2变体。调控D-丙氨酸的基因PLPBP是主要的基因靶点。本文方法具有通用性，适用于现有病毒及宿主细胞，为应对病毒性疾病提供新思路。
Abstract:
Abstract: A target prediction approach to inhibit SARS-CoV-2 replication through metabolic difference analysis is presented. The approach is based on gene expression data from lung host cells, reconstructs a network model of the parts of the host cell metabolic system that are reprogrammed after viral invasion, and identifies candidate targets using single-gene knockout and cytotoxicity test. The robustness of antiviral targets against multiple currently known variants of SARS-CoV-2 is also analyzed. The results indicate that D-alanine is a key metabolite affecting SARS-CoV-2 replication and is applicable to all current SARS-CoV-2 variants. The gene regulating D-alanine (PLPBP) is the main gene target. The proposed approach is applicable to the existing viruses and host cells, providing new ideas for viral disease management.

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备注/Memo

备注/Memo:
【收稿日期】2023-06-15 【基金项目】国家重点基础研究发展计划（2017YFA0505502）；中国科学院战略性先导科技专项（XDB38000000） 【作者简介】齐瑜鹏，硕士，主要从事生物信息学研究，E-mail: patrickqi@mail.ustc.edu.cn
更新日期/Last Update: 2023-12-27