[1]黄宝添,林佩贤.周围型肺癌立体定向放射治疗中采用实体肿瘤靶区推量技术的可行性研究—基于剂量学分析[J].中国医学物理学杂志,2023,40(3):272-277.[doi:DOI:10.3969/j.issn.1005-202X.2023.03.003]
　HUANG Baotian,LIN Peixian.A feasible study of boosting target dose for peripheral lung cancer patients undergoing stereotactic body radiotherapy: a dosimetric analysis[J].Chinese Journal of Medical Physics,2023,40(3):272-277.[doi:DOI:10.3969/j.issn.1005-202X.2023.03.003]
点击复制

周围型肺癌立体定向放射治疗中采用实体肿瘤靶区推量技术的可行性研究—基于剂量学分析()
分享到：

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
40卷
期数:
2023年第3期
页码:
272-277
栏目:
医学放射物理
出版日期:
2023-03-29

文章信息/Info

Title:
A feasible study of boosting target dose for peripheral lung cancer patients undergoing stereotactic body radiotherapy: a dosimetric analysis
文章编号:
1005-202X（2023）03-0272-06
作者:
黄宝添1; 林佩贤2
1.汕头大学医学院附属肿瘤医院放疗科， 广东 汕头515041； 2.汕头大学医学院第二附属医院医院感染管理科， 广东 汕头 515041
Author(s):
HUANG Baotian1;  LIN Peixian2
1. Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou 515041, China 2. Department of Nosocomial Infection Management, the Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China
关键词:
周围型肺癌; 立体定向放射治疗; 肿瘤靶区推量; 可行性; 剂量学
Keywords:
Keywords: peripheral lung cancer stereotactic body radiotherapy tumor dose boosting feasibility dosimetry
分类号:
R734.2；R815.6
DOI:
DOI:10.3969/j.issn.1005-202X.2023.03.003
文献标志码:
A
摘要:
目的：通过研究周围型肺癌立体定向放射治疗中提高肿瘤靶区最高剂量对剂量限制参数和正常器官剂量的影响，探讨使用实体肿瘤靶区推量技术的可行性，为临床治疗提供剂量学参考依据。方法：收集19例周围型早期肺癌患者的CT图像资料，重新设计放射治疗计划，初始治疗计划在满足放射治疗肿瘤协作组（RTOG）0915号报告关于剂量限制参数的情况下，以2 Gy的剂量爬升梯度分别对肿瘤靶区进行提量，共得到5组治疗计划。结果：5组计划的剂量限制参数均能满足RTOG0915号报告要求。5组计划的剂量限制参数和正常器官剂量无显著差异，但是肿瘤靶区最高剂量存在显著差异（P<0.05），最高和最低剂量组剂量差异可达6.6 Gy。结论：提高肿瘤靶区最高剂量对剂量限制参数和正常器官剂量没有显著影响。由于提高靶区内最高剂量会直接影响肿瘤的局部控制率，因此在满足剂量限制参数的前提下，建议使用实体肿瘤靶区推量技术以提高肿瘤靶区内的最高剂量。
Abstract:
Abstract: Objective To explore the feasibility of tumor dose boosting strategy by investigating the effects of boosting the maximum dose in the target on dose-restricting parameters and normal tissue doses for peripheral lung cancer patients undergoing stereotactic body radiotherapy (SBRT), thereby providing a dosimetric reference basis for clinical treatment. Methods The CT datasets from 19 patients with peripheral lung cancer were included for treatment replanning. The dose-restricting parameters of the initial treatment plans were designed to meet the requirement of Radiation Therapy Oncology Group (RTOG) 0915 report, and then another 4 groups of plans were designed by boosting the maximum dose in the target at a 2 Gy gradient. Results The dose-restricting parameters of the 5 groups of plans met the requirement of RTOG 0915 report. The dose-restricting parameters and normal tissue doses did not differ significantly among the 5 groups of plans. However, the maximum dose in the target differed by up to 6.6 Gy (P<0.05). Conclusion Boosting the tumor dose does not affect the dose-restricting parameters and normal tissue doses for lung cancer patients undergoing SBRT. As the maximum dose is reported to be associated with local control, a strategy of tumor dose boosting is recommended in clinical practice for increasing the maximum dose in the target under the premise of meeting the dose-restricting requirement.

相似文献/References:

[1]张淑慧,杨敬贤,贾飞,等.肿瘤立体定向放射治疗摆位误差分析与质量控制[J].中国医学物理学杂志,2013,30(02):3988.[doi:10.3969/j.issn.1005-202X.2013.02.006]
[2]张基永,张武哲,陆佳扬,等.Truebeam加速器无均整滤过器6MV X射线SBRT治疗计划的剂量验证评估[J].中国医学物理学杂志,2015,32(04):510.[doi:10.3969/j.issn.1005-202X.2015.04.013]
　[J].Chinese Journal of Medical Physics,2015,32(3):510.[doi:10.3969/j.issn.1005-202X.2015.04.013]
[3]岳海振,张艺宝,胡俏俏,等.PTW 1000SRS与729矩阵在非均整模式下剂量验证对比[J].中国医学物理学杂志,2016,33(1):19.[doi:DOI:10.3969/j.issn.1005-202X.2016.01.005]
　[J].Chinese Journal of Medical Physics,2016,33(3):19.[doi:DOI:10.3969/j.issn.1005-202X.2016.01.005]
[4]王小深,鞠忠建,解传滨,等.射波刀准直器个数对脊柱转移瘤放疗计划的影响[J].中国医学物理学杂志,2016,33(2):195.[doi:10.3969/j.issn.1005-202X.2016.02.018]
[5]黄啸天,张俊,周云峰,等. 方差分析法在肺癌立体定向放射治疗摆位误差及计划靶区外放边界中的应用[J].中国医学物理学杂志,2017,34(6):579.[doi:DOI:10.3969/j.issn.1005-202X.2017.06.008]
　[J].Chinese Journal of Medical Physics,2017,34(3):579.[doi:DOI:10.3969/j.issn.1005-202X.2017.06.008]
[6]李玉成,陈维军,单国平,等. 摆位误差对立体定向放射治疗计划剂量学验证的影响[J].中国医学物理学杂志,2018,35(8):869.[doi:DOI:10.3969/j.issn.1005-202X.2018.08.001]
　LI Yucheng,CHEN Weijun,et al. Effects of setup errors on dosimetric verification of stereotactic body radiotherapy plan[J].Chinese Journal of Medical Physics,2018,35(3):869.[doi:DOI:10.3969/j.issn.1005-202X.2018.08.001]
[7]胡晓伟,史玉静,李金凯,等. 共面与非共面的VMAT在肺癌放疗中的剂量学比较[J].中国医学物理学杂志,2018,35(11):1246.[doi:DOI:10.3969/j.issn.1005-202X.2018.11.002]
　HU Xiaowei,SHI Yujing,LI Jinkai,et al. Dosimetric comparison of coplanar and non-coplanar volumetric modulated arc therapy for lung cancer[J].Chinese Journal of Medical Physics,2018,35(3):1246.[doi:DOI:10.3969/j.issn.1005-202X.2018.11.002]
[8]聂鑫,韩军,杨晶,等. 国产医用直线加速器开展立体定向放射治疗的可行性研究[J].中国医学物理学杂志,2019,36(2):130.[doi:DOI:10.3969/j.issn.1005-202X.2019.02.002]
　NIE Xin,HAN Jun,YANG Jing,et al. Feasibility study of applying domestic medical linear accelerators in stereotactic radiotherapy[J].Chinese Journal of Medical Physics,2019,36(3):130.[doi:DOI:10.3969/j.issn.1005-202X.2019.02.002]
[9]程晓龙,刘吉平,杨双燕,等. 基于螺旋断层放疗的立体定向放射治疗多参量数据分析[J].中国医学物理学杂志,2019,36(3):259.[doi:DOI:10.3969/j.issn.1005-202X.2019.03.003]
　CHENG Xiaolong,LIU Jiping,YANG Shuangyan,et al. Multiparameter data analysis of stereotactic body radiotherapy based on helical tomotherapy[J].Chinese Journal of Medical Physics,2019,36(3):259.[doi:DOI:10.3969/j.issn.1005-202X.2019.03.003]
[10]张白霖,戴振晖,朱琳,等. 基于光学表面监测系统进行头部肿瘤放疗实时定位准确性的初步研究[J].中国医学物理学杂志,2019,36(4):389.[doi:DOI:10.3969/j.issn.1005-202X.2019.04.004]
　ZHANG Bailin,DAI Zhenhui,ZHU Lin,et al. Preliminary study on accuracy of real-time positioning with optical surface monitoring system during radiotherapy for head tumor[J].Chinese Journal of Medical Physics,2019,36(3):389.[doi:DOI:10.3969/j.issn.1005-202X.2019.04.004]
[11]黄宝添,林佩贤,罗利梅,等.利用放射生物学模型比较周围型肺癌立体定向放射治疗中的3种剂量方案[J].中国医学物理学杂志,2021,38(12):1472.[doi:DOI:10.3969/j.issn.1005-202X.2021.12.004]
　HUANG Baotian,LIN Peixian,LUO Limei,et al.Comparison among 3 dose schedules in stereotactic body radiotherapy for peripheral lung cancer based on radiobiological models[J].Chinese Journal of Medical Physics,2021,38(3):1472.[doi:DOI:10.3969/j.issn.1005-202X.2021.12.004]

备注/Memo

备注/Memo:
【收稿日期】2022-10-21 【基金项目】国家自然科学基金（81602667）；汕头市医疗卫生科技计划项目（汕府科［2022］88号） 【作者简介】黄宝添，硕士，高级工程师，研究方向：肿瘤放射物理，E-mail: hbt830910@126.com
更新日期/Last Update: 2023-03-29