[1]黄利生,伍方财,林柏翰,等.同步推量加速调强放疗联合化疗治疗局部晚期非小细胞肺癌的前瞻性研究[J].中国医学物理学杂志,2022,39(3):272-276.[doi:DOI:10.3969/j.issn.1005-202X.2022.03.002]
　HUANG Lisheng,WU Fangcai,LIN Baihan,et al.Simultaneous modulated accelerated radiotherapy combined with chemotherapy for the treatment of locally advanced non-small cell lung cancer: a prospective study[J].Chinese Journal of Medical Physics,2022,39(3):272-276.[doi:DOI:10.3969/j.issn.1005-202X.2022.03.002]
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同步推量加速调强放疗联合化疗治疗局部晚期非小细胞肺癌的前瞻性研究()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
39卷
期数:
2022年第3期
页码:
272-276
栏目:
医学放射物理
出版日期:
2022-03-28

文章信息/Info

Title:
Simultaneous modulated accelerated radiotherapy combined with chemotherapy for the treatment of locally advanced non-small cell lung cancer: a prospective study
文章编号:
1005-202X（2022）03-0272-05
作者:
黄利生1; 伍方财1; 林柏翰1; 许镒洧2; 李东升1; 陈洁1
1.汕头大学医学院附属肿瘤医院放疗科， 广东 汕头 515041； 2.汕头大学医学院附属肿瘤医院检验科， 广东 汕头 515041
Author(s):
HUANG Lisheng1;  WU Fangcai1;  LIN Baihan1;  XU Yiwei2;  LI Dongsheng1;  CHEN Jie1
1. Department of Radiotherapy, Cancer Hospital of Shantou University Medical College, Shantou 515041, China 2. Department of Clinical Laboratory, Cancer Hospital of Shantou University Medical College, Shantou 515041, China
关键词:
非小细胞肺癌; 同步推量加速调强放疗; 同步放化疗; 疗效
Keywords:
Keywords: non-small cell lung cancer simultaneous modulated accelerated radiotherapy concurrent radiochemotherapy therapeutic effect
分类号:
R734.2；R815
DOI:
DOI:10.3969/j.issn.1005-202X.2022.03.002
文献标志码:
A
摘要:
目的：评估同步推量加速调强放疗联合化疗治疗局部晚期非小细胞肺癌的疗效和安全性。方法：采用同步推量加速调强放疗技术联合紫杉醇和卡铂同步化疗对48例新诊断Ⅲ期局部晚期非小细胞肺癌患者进行治疗；处方剂量包括肺部原发灶PTV1为69 Gy（2.3 Gy/F），转移淋巴结PTV2为64 Gy（2.13 Gy/F），亚临床病灶PTV3为60 Gy（2.0 Gy/F）。对放疗计划进行剂量学分析，并观察分析生存期、无进展生存期、客观缓解率和急性毒性反应。结果：48例患者均完成放化疗，PTV1、PTV2、PTV3的Dmean分别为（70.3±2.4）、（66.5±2.1）、（64.5±3.1） Gy。中位生存期为22.0个月，中位无进展生存期为17.0个月，客观缓解率为72.9%，1年生存率为78.7%，2年生存率为45.8%；未发现严重食管炎、肺炎和心脏毒性。结论：同步推量加速调强放疗技术联合化疗治疗局部晚期非小细胞肺癌是可行的，急性毒性反应可控，但仍需要进一步的随访评估远期毒性。
Abstract:
Abstract: Objective To investigate the therapeutic effect and safety of simultaneous modulated accelerated radiotherapy (SMART) combined with chemotherapy in the treatment of locally advanced non-small cell lung cancer (NSCLC). Methods Forty-eight cases which were newly diagnosed with stage Ⅲ locally advanced NSCLC were treated by concurrent chemoradiotherapy using SMART combined with paclitaxel and carboplatin. The prescribed doses were 69 Gy (2.3 Gy/F) for primary lung lesion PTV1, 64 Gy (2.13 Gy/F) for metastatic lymph nodes PTV2, and 60 Gy (2.0 Gy/F) for subclinical lesion volume PTV3. Dosimetric analysis was carried out on the radiotherapy plans. Moreover, overall survival, progression-free survival, overall response rate and acute toxicity were analyzed. Results All the 48 patients completed the course of concurrent radiochemotherapy. The Dmean to PTV1, PTV2 and PTV3 were (70.3±2.4), (66.5±2.1) and (64.5±3.1) Gy, respectively. The median overall survival and progression-free survival were 22.0 months and 17.0 months, respectively and the overall response rate was 72.9% and the 1-year and 2-year survival rates were 78.7% and 45.8%, respectively. No serious esophagitis, pneumonitis and cardiotoxicity were found. Conclusion SMART combined with chemotherapy is effective in the treatment of locally advanced NSCLC, with tolerable acute toxicity, but more follow-up is required to evaluate the late toxicity.

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备注/Memo

备注/Memo:
【收稿日期】2021-11-18 【基金项目】国家自然科学基金青年科学基金（31600632）；汕头市医疗卫生科技计划（汕府科[2018] 121号）；汕头大学医学院附属肿瘤医院青年科研基金（2015030916） 【作者简介】黄利生，硕士，主治医师，研究方向：胸部肿瘤放化疗，E-mail: 364965305@qq.com 【通信作者】陈洁，硕士，主治医师，研究方向：胸部肿瘤放射治疗，E-mail: 295863932@qq.com
更新日期/Last Update: 2022-03-28