[1]刘显旺,刘宏,邓靓娜,等.能谱CT基物质分离技术定量评估乙肝肝纤维化分期的价值[J].中国医学物理学杂志,2022,39(6):701-704.[doi:DOI:10.3969/j.issn.1005-202X.2022.06.008]
　LIU Xianwang,,et al.Application of basis material decomposition technique with spectral CT in quantitatively evaluating the stage of hepatitis B liver fibrosis[J].Chinese Journal of Medical Physics,2022,39(6):701-704.[doi:DOI:10.3969/j.issn.1005-202X.2022.06.008]
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能谱CT基物质分离技术定量评估乙肝肝纤维化分期的价值()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
39卷
期数:
2022年第6期
页码:
701-704
栏目:
医学影像物理
出版日期:
2022-06-27

文章信息/Info

Title:
Application of basis material decomposition technique with spectral CT in quantitatively evaluating the stage of hepatitis B liver fibrosis
文章编号:
1005-202X（2022）06-0701-04
作者:
刘显旺1; 2; 3; 4; 刘宏1; 2; 3; 4; 邓靓娜1; 2; 3; 4; 李昇霖1; 2; 3; 4; 薛彩强1; 2; 3; 4; 邓娟1; 2; 3; 4; 孙秋1; 2; 3; 4; 周俊林1; 2; 3; 4
1.兰州大学第二医院放射科， 甘肃 兰州 730030； 2.兰州大学第二临床医学院， 甘肃 兰州 730030； 3.甘肃省医学影像重点实验室， 甘肃 兰州 730030； 4.医学影像人工智能甘肃省国际科技合作基地， 甘肃 兰州 730030
Author(s):
LIU Xianwang1;  2;  3;  4;  LIU Hong1;  2;  3;  4;  DENG Liangna1;  2;  3;  4;  LI Shenglin1;  2;  3;  4;  XUE Caiqiang1;  2;  3;  4;  DENG Juan1;  2;  3;  4;  SUN Qiu1;  2;  3;  4;  ZHOU Junlin1;  2;  3;  4
1. Department of Radiology, Lanzhou University Second Hospital, Lanzhou 730030, China 2. The Second Clinical School of Lanzhou University, Lanzhou 730030, China 3. Key Laboratory of Medical Imaging of Gansu Province, Lanzhou 730030, China 4. Gansu International Scientific and Technological Cooperation Base of Medical Imaging Artificial Intelligence, Lanzhou 730030, China
关键词:
能谱CT; 基物质分离; 乙型肝炎; 肝纤维化
Keywords:
Keywords: spectral CT basis material decomposition hepatitis B liver fibrosis
分类号:
R816.5
DOI:
DOI:10.3969/j.issn.1005-202X.2022.06.008
文献标志码:
A
摘要:
目的：探讨能谱CT基物质分离技术在定量评估乙肝肝纤维化分期中的应用价值。方法：选取33例乙肝肝纤维化患者为试验组，18名健康体检者为对照组，采用能谱CT基物质分离技术分别在碘（水）基物质图上测量每名受检者肝实质及同层腹主动脉的碘（水）浓度，并计算肝脏标准化碘浓度（NIC）。以肝穿刺活检病理结果为金标准，采用单因素方差分析及最小显著性差异法比较不同分期乙肝肝纤维化间NIC的差异，Spearman相关分析用于评估乙肝肝纤维化分期与NIC之间的相关性，同时绘制ROC曲线分析NIC评估不同分期乙肝肝纤维化的价值。结果：不同分期乙肝肝纤维化间NIC存在差异（F=36.889, P<0.001）。NIC与不同分期乙肝肝纤维化间呈高度负相关性（r=-0.847, P<0.001）。NIC鉴别S0<和≥s1、s1><和≥s2、 />
Abstract:
Abstract: Objective To explore the application value of basis material decomposition technique with spectral CT in the quantitative assessment of hepatitis B liver fibrosis stage. Methods Thirty-three patients with hepatitis B liver fibrosis were enrolled as experimental group, and 18 healthy subjects as control group. The iodine (water) concentration of liver parenchyma and abdominal aorta in the same layer of each patient was measured on the iodine (water) basis material map using basis material decomposition technique with spectral CT, and then the normalized iodine concentration (NIC) of the liver was calculated. Taking the pathological results of liver biopsy as the gold standard, one-way analysis of variance and least significant difference were used to compare the differences in NIC between different stages of hepatitis B liver fibrosis. Spearman correlation analysis was used to evaluate the correlation between hepatitis B liver fibrosis stage and NIC. Meanwhile, ROC curve was drawn to analyze the value of NIC in evaluating different stages of hepatitis B liver fibrosis. Results There were differences in NIC among different stages of hepatitis B liver fibrosis (F=36.889, P<0.001), and NIC had a negative correlation with different stages of hepatitis B liver fibrosis (r=-0.847, P<0.001). The AUC, sensitivity, specificity, positive predictive value, negative predictive value and accuracy of NIC in differentiating between S0< and ≥S1, S1< and ≥S2,

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备注/Memo

备注/Memo:
【收稿日期】2021-10-19 【基金项目】国家自然科学基金（81772006）；兰州大学第二医院“萃英科技创新计划”应用基础研究项目（CY2018-QN09） 【作者简介】刘显旺，博士，研究方向：中枢及腹部影像诊断学，E-mail: 1553537867@qq.com 【通信作者】周俊林，博士，主任医师，教授，研究方向：神经影像学，E-mail: lzuzjl601@163.com
更新日期/Last Update: 2022-06-27