[1]李纪璇,单国平,王彬冰,等.形变配准算法在宫颈癌后装治疗分次间总剂量评估中的应用[J].中国医学物理学杂志,2021,38(5):534-539.[doi:DOI:10.3969/j.issn.1005-202X.2021.05.002]
　LI Jixuan,SHAN Guoping,WANG Binbing,et al.Evaluation of multi-fractional dose accumulation with deformable registration algorithm in brachytherapy for cervical cancer[J].Chinese Journal of Medical Physics,2021,38(5):534-539.[doi:DOI:10.3969/j.issn.1005-202X.2021.05.002]
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形变配准算法在宫颈癌后装治疗分次间总剂量评估中的应用()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
38卷
期数:
2021年第5期
页码:
534-539
栏目:
医学放射物理
出版日期:
2021-05-01

文章信息/Info

Title:
Evaluation of multi-fractional dose accumulation with deformable registration algorithm in brachytherapy for cervical cancer
文章编号:
1005-202X（2021）05-0534-06
作者:
李纪璇1; 单国平2; 王彬冰2; 周剑良1
1.南华大学核科学技术学院， 湖南 衡阳 421001； 2.中国科学院大学附属肿瘤医院放射物理室， 浙江 杭州 310022
Author(s):
LI Jixuan1;  SHAN Guoping2;  WANG Binbing2;  ZHOU Jianliang1
1. School of Nuclear Science and Technology, University of South China, Hengyang 421001, China 2. Department of Radiation Physics, Cancer Hospital, University of Chinese Academy of Sciences, Hangzhou 310022, China
关键词:
宫颈癌; 后装治疗; 形变配准; 累积剂量
Keywords:
Keywords: cervical cancer brachytherapy deformable registration cumulative dose
分类号:
R811.1
DOI:
DOI:10.3969/j.issn.1005-202X.2021.05.002
文献标志码:
A
摘要:
目的：量化分析后装治疗中，使用不同累积剂量计算方法导致的总剂量评估差异。方法：使用混合形变配准算法，对32例已完成后装插植治疗的宫颈癌患者共计进行108次形变配准，并计算每个患者的形变总剂量。根据膀胱和直肠的体积控制情况将32例患者分为体积控制组（18例）和体积未控制组（14例），计算比较组间累积剂量体积参数（D0.1 cc、D1 cc、D2 cc）和相似度系数（DSC），并与GEC-ESTRO推荐的分次间剂量累加方法相比较。结果：DSC随形变图像相对体积比值的增大而变差。体积控制组中，GEC-ESTRO推荐方法和形变累积剂量差异（DDIR/DGEC）较小。对于膀胱，体积控制组D2 cc的DDIR/DGEC最大值为1.05，低于未控组1.07；DDIR/DGEC最小值为0.91，高于未控组0.80。提示在使用形变剂量评估过程中，形变剂量值可能比GEC-ESTRO推荐的剂量计算方法偏高5%~7%或偏低9%~20%，偏高和偏低的原因主要为参与形变的体积差异导致剂量网格缩放。而D0.1 cc、D1 cc的DDIR/DGEC更接近1。对于直肠，控制组没有观察到DDIR/DGEC偏高的情况，D2 cc的DDIR/DGEC最大值为0.99，低于未控组1.06；最小值为0.80，低于未控组0.85，但未控制组平均偏高6%。而直肠的D0.1 cc、D1 cc、D2 cc的累积剂量比值都较接近，并且差异不如膀胱显著。结论：在后装治疗中，形变体积可以影响到形变累积剂量的计算结果，合理控制形变轮廓的体积不仅有助于提高形变的准确性，而且形变总剂量评估结果更稳定，建议在后装治疗过程中重视对膀胱和直肠的体积控制。
Abstract:
Abstract: Objective To quantitatively analyze the differences in total dose assessment caused by different methods for calculating cumulative dose in brachytherapy. Methods A total of 108 deformation registrations using hybrid deformation registration algorithm were performed on 32 patients with cervical cancer who had completed brachytherapy, and the total deformation dose of each patient was calculated. According to the volume controls of the bladder and the rectum, 32 patients were divided into volume control group (18 cases) and volume uncontrolled group (14 cases). The cumulative dose volume parameters (D0.1 cc, D1 cc, D2 cc) and Dice similarity coefficient were compared between two groups, and then compared with the results obtained by multi-fractional dose accumulation method recommended by GEC-ESTRO. Results The Dice similarity coefficient became worse as the relative volume ratio of the deformed image increased. In volume control group, the difference between the results obtained by the method recommended by GEC-ESTRO and deformable cumulative dose (DDIR/DGEC) was small. For the bladder, the maximum DDIR/DGEC of D2 cc in volume control group was 1.05, lower than 1.07 in volume uncontrolled group, and the minimum DDIR/DGEC was 0.91, higher than 0.80 in volume uncontrolled group. It suggested that in deformation dose evaluation, the deformation dose may be 5%-7% higher or 9%-20% lower than the results calculated by the recommended method of GEC-ESTRO. The main reason for the differences was dose grid scaling caused by volume difference in image deformation. The DDIR/DGEC of D0.1 cc and D1 cc was closer to 1. For the rectum, high DDIR/DGEC was not observed in volume control group. The maximum and minimum DDIR/DGEC of D2 cc were 0.99 and 0.80 in volume control group, lower than 1.06 and 0.85 in volume uncontrolled group, indicating that the DDIR/DGEC of uncontrolled group was 6% higher. The cumulative dose ratios of D0.1 cc, D1 cc, and D2 cc of the rectum were all close, and the difference was not as significant as that of the bladder. Conclusion In brachytherapy, the deformation volume can affect the calculation result of deformation cumulative dose. A reasonable control of the volume of the deformation contour is not only helpful to improve the accuracy of the deformation, but also makes the evaluation results of the total deformation dose more stable. It is recommended to pay attention to the volume control of the bladder and the rectum during brachytherapy.

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备注/Memo

备注/Memo:
【收稿日期】2020-12-26 【基金项目】浙江省自然科学基金-数理医学学会联合基金（LSY19H180002）；辐射物理及技术教育部重点实验室开放课题（2018SCURPT09）；浙江省医药卫生科技项目（2018PY005） 【作者简介】李纪璇，硕士研究生，研究方向：放射物理治疗，E-mail: 313083521@qq.com 【通信作者】周剑良，博士生导师，研究方向：核技术及应用，E-mail: 13327341099@qq.com
更新日期/Last Update: 2021-05-31