[1]邓官华,李少群,周巧敏,等.CT造影剂对脑动静脉畸形VMAT计划剂量分布的影响[J].中国医学物理学杂志,2021,38(5):556-560.[doi:DOI:10.3969/j.issn.1005-202X.2021.05.006]
　DENG Guanhua,LI Shaoqun,ZHOU Qiaomin,et al.Effects of CT contrast agent on dose calculations for volumetric modulated arc therapy of brain arteriovenous malformations[J].Chinese Journal of Medical Physics,2021,38(5):556-560.[doi:DOI:10.3969/j.issn.1005-202X.2021.05.006]
点击复制

CT造影剂对脑动静脉畸形VMAT计划剂量分布的影响()
分享到：

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
38卷
期数:
2021年第5期
页码:
556-560
栏目:
医学放射物理
出版日期:
2021-05-01

文章信息/Info

Title:
Effects of CT contrast agent on dose calculations for volumetric modulated arc therapy of brain arteriovenous malformations
文章编号:
1005-202X（2021）05-0556-05
作者:
邓官华; 李少群; 周巧敏; 罗日顺; 张平; 戴鹏; 罗龙辉; 赖名耀; 山常国; 蔡林波
广东三九脑科医院肿瘤综合治疗中心， 广东 广州 510510
Author(s):
DENG Guanhua;  LI Shaoqun;  ZHOU Qiaomin;  LUO Rishun;  ZHANG Ping;  DAI Peng;  LUO Longhui;  LAI Mingyao;  SHAN Changguo;  CAI Linbo
Department of Oncology, Guangdong Sanjiu Brain Hospital, Guangzhou 510510, China
关键词:
脑动静脉畸形; 容积旋转调强; CT造影剂; 剂量计算
Keywords:
Keywords: brain arteriovenous malformation volumetric modulated arc therapy CT contrast agent dose calculation
分类号:
R739.41；R815.6
DOI:
DOI:10.3969/j.issn.1005-202X.2021.05.006
文献标志码:
A
摘要:
目的：探讨CT造影剂对脑动静脉畸形VMAT计划剂量分布的影响。方法：选取15例脑动静脉畸形患者为研究对象，在相同体位下行平扫和增强CT扫描。在增强CT图像上勾画靶区和危及器官，通过图像配准将上述结构复制至平扫CT图像。在VARIAN Eclipse 13.6计划系统中完成增强CT图像的VMAT计划设计（5条弧），并将此计划复制至平扫CT图像，不进行通量优化，重新计算剂量分布。记录两组计划的靶区、危及器官以及感兴趣区域的CT值，靶区的D2%、D98%、Dmean、适形度指数、均匀性指数以及梯度跌落指数，危及器官Dmax以及正常组织受照射体积V2 Gy、V10 Gy、V12 Gy，并采用非参数配对Wilcoxon检验分析两组数据间的差异。结果：在靶区和感兴趣区域处，增强图像的CT值显著高于平扫图像（P=0.001）；而在其他组织处，两组图像的CT值比较均无统计学差异（P>0.05）。两组计划的剂量学参数差异小于2%，且无统计学差异（P>0.05）。结论：CT造影剂对脑动静脉畸形VMAT计划剂量分布的影响较小，临床上可忽略。
Abstract:
Abstract: Objective To investigate the effects of CT contrast agent on the dose calculations for volumetric modulated arc therapy (VMAT) of brain arteriovenous malformations. Methods Fifteen patients with brain arteriovenous malformations were enrolled in the study and underwent contrast enhanced CT (CECT) scan and non-enhanced CT (NECT) scan in the same position. Target areas and organs-at-risk were delineated on CECT image, and then copied to NECT image after image registration. VARIAN Eclipse planning system 13.6 was used to generate VMAT plan with 5 arcs based on CECT, and the generated plan was copied to NECT for recalculating dose distributions, without flux optimization. The Hounsfield unit (HU) of planning target volume, organs-at-risk and region of interest, the D2%, D98%, Dmean, conformity index, homogeneity index and gradient index of planning target volume, the Dmax of organs-at-risk, and the V2 Gy, V10 Gy and V12 Gy of normal tissues were recorded and analyzed. A Wilcoxon signed rank test was conducted to compare the differences between two groups of data. Results The HU of planning target volume and region of interest in CECT were higher than those in NECT (P=0.001), and there was no significant difference in HU of other tissues (P>0.05). The differences in dosimetric parameters between two groups were less than 2%, without significant differences (P>0.05). Conclusion The effect of CT contrast agent on the dose calculation for VMAT of brain arteriovenous malformations is ignorable.

相似文献/References:

[1]孙小喆,孟慧鹏,史孝伟,等.胸部肿瘤容积旋转调强放射治疗摆位误差分析[J].中国医学物理学杂志,2015,32(01):34.[doi:10.3969/j.issn.1005-202X.2015.01.009]
[2]孙晓欢,周咏春,谭丽娜,等.容积旋转调强与固定野调强在宫颈癌术后放疗中的剂量学比较[J].中国医学物理学杂志,2014,31(01):4604.[doi:10.3969/j.issn.1005-202X.2014.01.003]
[3]张俊俊,邱小平,李奇欣,等.ArcCheck系统在鼻咽癌容积旋转调强剂量验证中的应用[J].中国医学物理学杂志,2014,31(05):5136.[doi:10.3969/j.issn.1005-202X.2014.05.009]
[4]张矛,金海国,苏清秀,等.肺癌静态调强与容积旋转调强放射治疗间比较[J].中国医学物理学杂志,2013,30(05):4364.[doi:10.3969/j.issn.1005-202X.2013.05.006]
[5]谭丽娜,孙晓欢,马奎,等.三维剂量验证系统Delta4在容积旋转调强计划剂量验证中的应用[J].中国医学物理学杂志,2013,30(06):4497.[doi:10.3969/j.issn.1005-202X.2013.06.007]
[6]王沛沛,刘哲铭,李彩虹,等.容积旋转调强与固定野动态调强在直肠癌新辅助放疗中的剂量学比较[J].中国医学物理学杂志,2015,32(06):901.[doi:doi:10.3969/j.issn.1005-202X.2015.06.030]
　[J].Chinese Journal of Medical Physics,2015,32(5):901.[doi:doi:10.3969/j.issn.1005-202X.2015.06.030]
[7]李丹明,王黎,孙新臣,等.中晚期宫颈癌适形调强放疗与容积旋转调强技术临床效果比较[J].中国医学物理学杂志,2016,33(5):478.[doi:10.3969/j.issn.1005-202X.2016.05.010]
　[J].Chinese Journal of Medical Physics,2016,33(5):478.[doi:10.3969/j.issn.1005-202X.2016.05.010]
[8]姚升宇,颜歌,赵国旗,等.容积旋转调强与固定野动态调强低剂量区比较[J].中国医学物理学杂志,2016,33(5):538.[doi:10.3969/j.issn.1005-202X.2016.05.022]
　[J].Chinese Journal of Medical Physics,2016,33(5):538.[doi:10.3969/j.issn.1005-202X.2016.05.022]
[9]高兴旺,Wang Yang,梁志强,等.快速容积旋转调强治疗系统的验收测试[J].中国医学物理学杂志,2016,33(6):541.[doi:DOI:10.3969/j.issn.1005-202X.2016.06.001]
　[J].Chinese Journal of Medical Physics,2016,33(5):541.[doi:DOI:10.3969/j.issn.1005-202X.2016.06.001]
[10]黎旦,宾石珍,程品晶,等.非晶硅电子射野影像系统与Arc CHECK在直肠癌容积旋转调强剂量验证中的应用[J].中国医学物理学杂志,2016,33(7):674.[doi:10.3969/j.issn.1005-202X.2016.07.006]
　[J].Chinese Journal of Medical Physics,2016,33(5):674.[doi:10.3969/j.issn.1005-202X.2016.07.006]

备注/Memo

备注/Memo:
【收稿日期】2021-01-15 【基金项目】广东三九脑科医院新技术项目（2017012） 【作者简介】邓官华，硕士，工程师，研究方向：肿瘤的早期发现及放射治疗，E-mail: gh.deng@foxmail.com 【通信作者】蔡林波，硕士，主任医师，研究方向：肿瘤的放射治疗及免疫治疗，E-mail: cailinbo999@163.com
更新日期/Last Update: 2021-05-31