[1]袁宇,徐林.骨髓间充质干细胞联合3D生物打印技术治疗骨缺损的研究进展[J].中国医学物理学杂志,2021,38(1):110-126.[doi:DOI:10.3969/j.issn.1005-202X.2021.01.019]
　YUAN Yu,XU Lin.Research progress of bone marrow mesenchymal stem cells combined with 3D bioprinting technology in the treatment of bone defects[J].Chinese Journal of Medical Physics,2021,38(1):110-126.[doi:DOI:10.3969/j.issn.1005-202X.2021.01.019]
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骨髓间充质干细胞联合3D生物打印技术治疗骨缺损的研究进展()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
38卷
期数:
2021年第1期
页码:
110-126
栏目:
生物材料与力学
出版日期:
2021-01-29

文章信息/Info

Title:
Research progress of bone marrow mesenchymal stem cells combined with 3D bioprinting technology in the treatment of bone defects
文章编号:
1005-202X（2021）01-0110-17
作者:
袁宇; 徐林
滨州医学院烟台附属医院， 山东 烟台 264010
Author(s):
YUAN Yu;  XU Lin
Yantai Affiliated Hospital of Binzhou Medical University, Yantai 264010, China
关键词:
骨髓间充质干细胞; 骨组织工程; 成骨分化; 3D打印; 综述
Keywords:
Keywords: bone marrow mesenchymal stem cells bone tissue engineering osteogenic differentiation 3D printing review
分类号:
R35；O482.1
DOI:
DOI:10.3969/j.issn.1005-202X.2021.01.019
文献标志码:
A
摘要:
骨缺损一直以来都是临床治疗中的难题，目前主要是行自体骨或人工骨移植治疗。但自体骨取骨的损伤和人工骨资源有限且价格昂贵使得骨移植手术在临床广泛应用受到限制。近年来国内外学者对骨髓间充质干细胞诱导分化成骨的研究愈加重视，对其分离提取和定向分化的研究取得了长足的进步。骨髓间充质干细胞可向成骨细胞、软骨细胞等分化且不存在排斥反应及伦理问题，其结合3D生物打印技术修复骨缺损具有精准化和可控性的优势，是一种极具潜力和应用前景的新型骨缺损修复技术。文章对骨髓间充质干细胞的生物学特性、成骨诱导及结合载体支架治疗骨缺损的研究进行阐述，为今后在骨缺损的临床治疗中提供理论依据。
Abstract:
Abstract: Bone defect has always been a difficult problem in clinical treatment, and autogenous bone or artificial bone transplantation is the main treatment at present. However, due to the damage caused by autologous bone graft and the limited and expensive resources of artificial bone, bone transplantation cannot be widely applied in clinical practice. In recent years, the scholars at home and abroad have paid more and more attention to the study of bone marrow mesenchymal stem cells (BMSCs) for they can induce osteogenic differentiation, and have made great progress in their isolation, extraction and directional differentiation. BMSCs can differentiate into osteoblasts, chondrocytes, etc., without rejection reaction and ethical problems. When combined with 3D bioprinting technology, it has advantages of precision and controllability in repairing bone defects and is a new bone defect repair technology with great potential and prospects. In this paper, the studies of the biological characteristics and osteogenic induction of BMSCs as well as its treatment of bone defects combined with carrier scaffolds were reviewed to provide a theoretical basis for the clinical treatment of bone defects in the future.

相似文献/References:

[1]张敏,李维娜,高贺奇,等.脉冲电磁场对大鼠骨髓间充质干细胞活性的影响[J].中国医学物理学杂志,2015,32(06):777.[doi:doi:10.3969/j.issn.1005-202X.2015.06.004]
　[J].Chinese Journal of Medical Physics,2015,32(1):777.[doi:doi:10.3969/j.issn.1005-202X.2015.06.004]
[2]洪亮,焦根龙.骨髓间充质干细胞成骨分化过程中碱性磷酸酶基因表达含量的变化[J].中国医学物理学杂志,2017,34(8):825.[doi:DOI:10.3969/j.issn.1005-202X.2017.08.014]
[3]李婷,陈莉智,黄文华. 骨髓间充质干细胞在基础医学及临床应用中的研究进展[J].中国医学物理学杂志,2019,36(8):962.[doi:DOI:10.3969/j.issn.1005-202X.2019.08.019]
　LI Ting,CHEN Lizhi,HUANG Wenhua,et al. Research progress on bone marrow mesenchymal stem cells in basic medicine and clinical application[J].Chinese Journal of Medical Physics,2019,36(1):962.[doi:DOI:10.3969/j.issn.1005-202X.2019.08.019]

备注/Memo

备注/Memo:
【收稿日期】2020-06-05 【作者简介】袁宇，硕士研究生，研究方向：骨折及骨缺损的治疗，E-mail: 624928567@qq.com
更新日期/Last Update: 2021-01-29