[1]李婷,陈莉智,黄文华. 骨髓间充质干细胞在基础医学及临床应用中的研究进展[J].中国医学物理学杂志,2019,36(8):962-967.[doi:DOI:10.3969/j.issn.1005-202X.2019.08.019]
 LI Ting,CHEN Lizhi,HUANG Wenhua,et al. Research progress on bone marrow mesenchymal stem cells in basic medicine and clinical application[J].Chinese Journal of Medical Physics,2019,36(8):962-967.[doi:DOI:10.3969/j.issn.1005-202X.2019.08.019]
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 骨髓间充质干细胞在基础医学及临床应用中的研究进展()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
36卷
期数:
2019年第8期
页码:
962-967
栏目:
医学生物物理
出版日期:
2019-08-26

文章信息/Info

Title:
 Research progress on bone marrow mesenchymal stem cells in basic medicine and clinical application
文章编号:
1005-202X(2019)08-0962-06
作者:
 李婷1陈莉智1黄文华12
 1.南方医科大学基础医学院人体解剖学国家重点学科, 广东 广州 510515; 2.广东省医学3D打印应用转化工程技术研究中心, 广东 广州 510515
Author(s):
 LI Ting1 CHEN Lizhi1 HUANG Wenhua1 2
 1. National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China; 2. Guangdong Province Medical 3D Printing Application Transformation Engineering Technology Research Center, Guangzhou 510515, China
关键词:
 骨髓间充质干细胞诱导分化分离培养临床应用基础研究综述
Keywords:
 Keywords: bone marrow mesenchymal stem cells inducing differentiation culture isolation clinical application basic research
分类号:
R329.2
DOI:
DOI:10.3969/j.issn.1005-202X.2019.08.019
文献标志码:
A
摘要:
 【摘要】骨髓间充质干细胞(BMSCs)作为庞大干细胞家族中的一名重要成员,具有极强的自我更新复制、增殖和多向分化的生物特性。20世纪以来,科学家利用BMSCs的这些生物特性,将其用于基础医学科研和临床应用中的研究已经越来越广泛,并且也取得重要进展。本文就BMSCs的生物特性、分离培养、基础科研和临床应用等方面的研究进展进行综述,重点介绍了BMSCs在骨科疾病、心血管科疾病、肝硬化以及椎间盘退变等治疗方面的研究,通过对这些治疗方案与技术的回顾,进一步探讨BMSCs在基础医学以及临床治疗领域的用途,为深入BMSCs的基础医学科研和临床应用方法提供一定的参考。
Abstract:
 Abstract: Bone marrow mesenchymal stem cells (BMSCs) which are an important member of stem cell family have the excellent biological characteristics of self-renewal, reproduction, multiplication and multi-differentiation. Since the 20th century, because of its special biological characteristics, BMSCs has been widely used in basic medicine and clinical application, and many significant progresses have been made. Herein the research progresses on the biological characteristics, isolation and culture, basic scientific researches and clinical applications of BMSCs are reviewed. The treatments of orthopedic diseases, cardiovascular diseases, liver cirrhosis and intervertebral disc degeneration with BMSCs are mainly introduced. The applications of BMSCs in basic medicine and clinical treatment are further explored through the review of the treatment strategies and techniques, thereby providing some references for the profound research on the basic scientific research and clinical application of BMSCs.

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备注/Memo

备注/Memo:
 【收稿日期】2019-02-25
【基金项目】国家重点研发计划(2017YFC1103400);国家自然基金(21773199,61427807);广东省科技计划项目(2016B090913004,2016B090925001,2017B090912006);深圳市医疗卫生“三名工程”高层次医学团队(SZSM201612019)
【作者简介】李婷,硕士在读,研究方向:生物3D打印,成软骨细胞,E-mail: 897379764@qq.com
【通信作者】黄文华,教授,博士生导师,研究方向:数字医学,医学3D打印,E-mail: huangwenhua2009@139.com
更新日期/Last Update: 2019-08-27