[1]王宪福,谢东东,刘畅,等.基于独立成分分析的青年吸烟者大脑静息态执行网络功能连接变化研究[J].中国医学物理学杂志,2020,37(3):289-292.[doi:DOI:10.3969/j.issn.1005-202X.2020.03.006]
　WANG Xianfu,XIE Dongdong,LIU Chang,et al.Changes of functional connectivity in executive network during the resting state in adolescent smokers: a research based on independent component analysis[J].Chinese Journal of Medical Physics,2020,37(3):289-292.[doi:DOI:10.3969/j.issn.1005-202X.2020.03.006]
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基于独立成分分析的青年吸烟者大脑静息态执行网络功能连接变化研究()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
37
期数:
2020年第3期
页码:
289-292
栏目:
医学影像物理
出版日期:
2020-03-25

文章信息/Info

Title:
Changes of functional connectivity in executive network during the resting state in adolescent smokers: a research based on independent component analysis
文章编号:
1005-202X（2020）03-0289-04
作者:
王宪福; 谢东东; 刘畅; 程永欣; 崔永婷; 田时雨; 喻大华
内蒙古科技大学信息工程学院， 内蒙古 包头 014010
Author(s):
WANG Xianfu;  XIE Dongdong;  LIU Chang;  CHENG Yongxin;  CUI Yongting;  TIAN Shiyu;  YU Dahua
School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou 014010, China
关键词:
青年吸烟者; 独立成分分析; 双重回归; 功能连接性; 功能性磁共振成像
Keywords:
Keywords: adolescent smoker;  independent component analysis;  dual regression;  functional connectivity;  functional magnetic resonance imaging
分类号:
R318
DOI:
DOI:10.3969/j.issn.1005-202X.2020.03.006
文献标志码:
A
摘要:
采用独立成分分析方法探索40名青年吸烟者和40名年龄与性别相匹配的非吸烟者的静息态功能磁共振数据，并结合“双重回归”方法探索吸烟者执行网络功能连接变化，同时将有变化的脑区与吸烟统计学数据进行Pearson’s双变量相关分析，例如年龄、包年、FTND、烟龄等。通过研究发现，青年吸烟者的大脑右中央执行网络的功能连接性增强，相关分析表明执行网络包含的背外侧前额叶皮质与烟龄呈显著性负相关（r=-0.339, P=0.032）。此项研究结果表明，吸烟对右侧中央执行网络的功能连接有一定的影响，研究结果可能为青年吸烟成瘾者的神经机制的特征提供额外的新见解。
Abstract:
Abstract: Independent component analysis (ICA) is used to explore the resting-state functional magnetic resonance imaging (fMRI) data from 40 adolescent smokers and 40 age-and gender- matched non-smokers, and then is combined with dual regression to explore the changes of functional connectivity in executive network in the smokers. Meanwhile, Pearson’s bivariate correlation analysis is carried out on both the changed brain regions and smoking statistics such as age, pack-years, FTND and smoking duration. It is found that the functional connectivity in the right central executive network in adolescent smokers is enhanced, and the results of correlation analysis shows that the dorsolateral prefrontal cortex contained in executive network is significantly negatively correlated with smoke duration (r=-0.339, P=0.032). The results of this research suggest that smoking has a certain impact on the functional connectivity in the right central executive network, and the findings in this research may provide additional new insights for the characteristics of the neural mechanism in adolescents with smoking addiction.

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备注/Memo

备注/Memo:
【收稿日期】2019-12-16 【基金项目】国家自然科学基金（81571753, 81571751, 81871430, 81871426, 61771266）；内蒙古自治区高等学校青年科技英才支持计划资助（NJYT-17-B11）；内蒙古自治区自然科学基金杰青培育基金（2019JQ07） 【作者简介】王宪福，硕士研究生，研究方向：医学图像处理，E-mail:fuxinxing521@163.com 【通信作者】喻大华，博士，教授，硕士生导师，研究方向：医学图像处理，E-mail:fmydh@imust.edu.cn
更新日期/Last Update: 2020-04-02