[1]牛瑞军,张晖,刘志强,等. 不同剂量算法在宫颈癌术后IMRT计划设计中的剂量学分析[J].中国医学物理学杂志,2018,35(2):145-150.[doi:DOI:10.3969/j.issn.1005-202X.2018.02.005]
　NIU Ruijun,ZHANG Hui,et al. Different dose calculation algorithms applied in the design of intensity-modulated radiotherapy plan for postoperative patients with cervical cancer: a dosimetric analysis[J].Chinese Journal of Medical Physics,2018,35(2):145-150.[doi:DOI:10.3969/j.issn.1005-202X.2018.02.005]
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 不同剂量算法在宫颈癌术后IMRT计划设计中的剂量学分析()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
35卷
期数:
2018年第2期
页码:
145-150
栏目:
医学放射物理
出版日期:
2018-02-08

文章信息/Info

Title:
 Different dose calculation algorithms applied in the design of intensity-modulated radiotherapy plan for postoperative patients with cervical cancer: a dosimetric analysis
文章编号:
1005-202X（2018）02-0145-06
作者:
 牛瑞军1; 2; 张晖3; 4; 刘志强1; 2; 程品晶5; 高力英1; 2; 赵林1; 2; 郭晴1; 2; 陶发利1; 2; 欧阳水根1; 2
 1.甘肃省肿瘤医院， 甘肃 兰州 730050； 2.甘肃省放射治疗研究中心， 甘肃 兰州 730050； 3.中国科学院大学， 北京 100049； 4.中国科学院近代物理研究所， 甘肃 兰州 730000； 5.南华大学核科学技术学院， 湖南 衡阳 421001
Author(s):
 NIU Ruijun1;  2;  ZHANG Hui3;  4;  LIU Zhiqiang1;  2;  CHENG Pinjing5;  GAO Liying1;  2;  ZHAO Lin1;  2;  GUO Qing1;  2;  TAO Fali1;  2;  OUYANG Shuigen1; 2
 1. Gansu Provincial Cancer Hospital, Lanzhou 730050, China; 2. Gansu Provincial Radiation Therapy Research Center, Lanzhou 730050, China; 3. University of Chinese Academy of Sciences, Beijing 100049, China; 4. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; 5. School of Nuclear Science and Technology, University of South China, Hengyang 421001, China
关键词:
 ; 宫颈癌; 调强放射治疗; 笔形束卷积算法; 各向异性分析算法; 放射治疗剂量
Keywords:
 ; cervical cancer;  intensity-modulated radiotherapy;  pencil beam convolution algorithm;  anisotropic analytical algorithm;  radiotherapy dosage
分类号:
R735.1
DOI:
DOI:10.3969/j.issn.1005-202X.2018.02.005
文献标志码:
A
摘要:
 目的：分析和比较宫颈癌术后调强放射治疗（IMRT）中笔形束卷积算法（PBC）和各向异性分析算法（AAA）的剂量学差异。 方法：随机选取30例宫颈癌术后患者，分别在Eclipse治疗计划系统上采用PBC算法和AAA算法设计IMRT计划，并生成相应的验证计划，比较靶区及危及器官的剂量学参数。 结果：两种算法计算所得靶区的D5%、D50%、D95%、D98%、Dmean均有显著统计学差异（P<0.05），PTV的均匀性指数和CTV的适形度指数均有显著统计学差异（P<0.05）；直肠和膀胱的V30、V40、Dmean，小肠的V10、V20、V30、Dmean，盆骨髓V10、V20、V30、V40、V50、Dmean，右股骨头的V20、V30、V40、V50、Dmean，左股骨头的V20、V30、V50、Dmean均有显著统计学差异（P<0.05）；并且除左右股骨头V40和直肠V50外，其余参考指标PBC算法结果均低于AAA算法；两种算法的验证计划无统计学差异。 结论：PBC算法与AAA算法在宫颈癌IMRT中虽然均符合临床要求，但存在一定的剂量学差异。与AAA算法比较，PBC算法高估了偏高剂量区域即靶区剂量，低估了偏低剂量区域即危及器官剂量。
Abstract:
 Objective To analyze and compare dosimetric differences between pencil beam convolution (PBC) algorithm and anisotropic analytical algorithm (AAA) in designing intensity-modulated radiotherapy plans for postoperative patients with cervical cancer. Methods Based on Eclipse treatment planning system, PBC algorithm and AAA were separately used to design intensity-modulated radiotherapy plans for 30 postoperative patients with cervical cancer, and the corresponding verification plans were also generated. The dosimetric parameters of target areas and organs-at-risk were compared. Results Statistical differences were found in the dosimetric parameters of target areas calculated with two different algorithms, including the D5%, D50%, D95%, D98%, Dmean of target areas, and the homogeneity index of planning target volume and conformity index of clinical target volume (P<0.05). The comparison of calculated organs-at-risk dose revealed that differences in V30, V40, Dmean of rectum and bladder, the V10, V20, V30, Dmean of small intestine, the V10, V20, V30, V40, V50, Dmean of marrow, the V20, V30, V40, V50, Dmean of the right femoral head and the V20, V30, V50, Dmean of the left femoral head were statistical significant (P<0.05), and that except for the V40 of the right and the left femoral head and the V50 of rectum, the other reference indexes calculated with PBC were lower than those calculated with AAA. The comparison of verification plans of two algorithms didn’t showed any statistical differences. Conclusion Although both AAA and PBC algorithm are conformed to the clinical requirement, some significant dosimetric differences between PBC and AAA are existed. Compared with AAA, PBC algorithm overestimates the dose of target area which is in high-dose region, and underestimates the dose of organs-at-risk which is in low-dose region.

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备注/Memo

备注/Memo:
 【收稿日期】2017-09-21
【基金项目】甘肃省自然科学基金（145RJZA178）；甘肃省卫生行业科研计划项目（GSWSKY-2015-29）
【作者简介】牛瑞军，助理工程师，主要从事放射治疗医学物理工作，E-mail: niuruijungs@163.com
【通信作者】欧阳水根，副主任医师，主要从事放射治疗医学物理工作，E-mail: ouyang328@126.com
更新日期/Last Update: 2018-01-29