[1]陈浩然,高维佳,焦青,等.青少年双相障碍缓解相患者功能磁共振成像局域一致性研究[J].中国医学物理学杂志,2018,35(1):47-53.[doi:DOI:10.3969/j.issn.1005-202X.2018.01.010]
 CHEN Haoran,GAO Weijia,JIAO Qing,et al. Regional homogeneity in euthymic patients with pediatric bipolar disorder: a resting-state functional magnetic resonance imaging study[J].Chinese Journal of Medical Physics,2018,35(1):47-53.[doi:DOI:10.3969/j.issn.1005-202X.2018.01.010]
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青少年双相障碍缓解相患者功能磁共振成像局域一致性研究()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
35卷
期数:
2018年第1期
页码:
47-53
栏目:
医学影像物理
出版日期:
2018-02-07

文章信息/Info

Title:
 Regional homogeneity in euthymic patients with pediatric bipolar disorder: a resting-state functional magnetic resonance imaging study
文章编号:
1005-202X(2018)01-0047-07
作者:
 陈浩然1高维佳2焦青1崔栋1许强4曹卫芳1郭永新1卢大力3肖茜3苏林雁3卢光明4
 1.泰山医学院放射学院, 山东 泰安 271016; 2.浙江大学医学院附属儿童医院儿童心理科, 浙江 杭州 310003; 3.中南大学湘雅二医院精神科, 湖南 长沙 410011; 4.中国人民解放军南京总医院, 江苏 南京 210002
Author(s):
 CHEN Haoran1 GAO Weijia2 JIAO Qing1 CUI Dong1 XU Qiang4 CAO Weifang1 GUO Yongxin1 LU Dali3 XIAO Qian3 SU Linyan3 LU Guangming4

1. School of Radiology, Taishan Medical University, Tai’an 271016, China; 2. Department of Child Psychology, Children’s Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou 310003, China; 3. Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha 410011, China; 4. Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China
关键词:
 功能磁共振成像局域一致性青少年双相障碍认知功能
Keywords:
 Keywords: functional magnetic resonance imaging regional homogeneity pediatric bipolar disorder cognitive function
分类号:
R445.2
DOI:
DOI:10.3969/j.issn.1005-202X.2018.01.010
文献标志码:
A
摘要:
 【摘 要】 目的:通过进行功能磁共振成像信号的局域一致性(ReHo)分析及认知功能测试,研究儿童青少年双相障碍(Pediatric Bipolar Disorder, PBD)缓解相患者的静息态脑活动一致性情况,以及脑活动与认知功能变化的关系。 方法:18例PBD缓解相患者和18例年龄、性别匹配的健康青少年参与功能磁共振数据采集,并对所有受试者进行临床检查和认知功能测试。计算磁共振成像信号的ReHo指标,分析ReHo结果与临床指标和认知测试的相关性。 结果:与健康青少年相比,PBD缓解相患者的Stroop色词干扰测试评分显著降低,ReHo数值在右侧小脑、左侧额下回、右侧后扣带回显著增加,在左侧顶上回及左侧辅助运动区显著降低。左侧额下回的ReHo值与发病年龄及Stroop色词干扰测试评分显著负相关,与连线测试评分显著正相关,右侧后扣带回及左侧辅助运动区的ReHo值分别与发病年龄呈显著负相关与正相关。 结论:PBD缓解相患者存在小脑、额下回、后扣带回、顶上回及辅助运动区的神经活动一致性异常改变,且额下回的神经活动异常与PBD缓解相患者的发病年龄及认知功能受损有关。
Abstract:
 Abstract: Objective To investigate the homogeneity of resting-state neuronal activity in euthymic patients with pediatric bipolar disorder (PBD) and analyze the relationship between neuronal activity and cognitive function. Methods Eighteen euthymic patients with PBD and 18 age- and gender-matched healthy controls were enrolled in this study. All the participants underwent functional magnetic resonance imaging (fMRI) scanning, clinical examination and cognitive function tests. The fMRI data were collected to calculate regional homogeneity (ReHo) values, and the association of ReHo values with the results of cognitive function tests and clinical findings were analyzed. Results Compared with healthy control subjects, the patients with PBD showed significantly decreased Stroop color-word test scores and significantly increased ReHo values in the brain regions including the right cerebellum, left inferior frontal gyrus (IFG), and right posterior cingulate cortex (PCC) but decreased ReHo values in the left superior parietal gyrus (SPG) and left supplementary motor area (SMA). ReHo value in the left IFG was negatively correlated with the age of disease onset and Stroop color-word test scores, and positively with the results of trail making test. ReHo value in the right PCC was negatively correlated while the value in the left SMA was positively correlated with the age of PBD onset. Conclusion Euthymic patients with PBD present with altered ReHo of neuronal activity in the brain regions including the cerebellum, IFG, PCC, the SPG and SMA. The dysfunction of the left IFG is related with cognitive impairment and age of disease onset in patients with PBD.

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备注/Memo

备注/Memo:
 【收稿日期】2017-08-18
【基金项目】国家自然科学基金(81371531);全军医学科技“十二五”科研重点基金(BWS11J063)
【作者简介】陈浩然,研究方向:医学影像技术,E-mail: 1071253121@qq.com;高维佳,E-mail: 421147453@qq.com
【通信作者】焦青,博士,教授,研究方向:磁共振成像技术、生物医学信号处理,E-mail: bingbao17@163.com;苏林雁,博士,主任医师,研究方向:精神病学,E-mail: xysulinyan@126.com
更新日期/Last Update: 2018-01-25