[1]汪峰. 三氧化二砷磁性微球的磁性能[J].中国医学物理学杂志,2018,35(2):224-227.[doi:DOI:10.3969/j.issn.1005-202X.2018.02.021]
　WANG Feng. Magnetic properties of arsenic trioxide magnetic microparticles[J].Chinese Journal of Medical Physics,2018,35(2):224-227.[doi:DOI:10.3969/j.issn.1005-202X.2018.02.021]
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 三氧化二砷磁性微球的磁性能()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
35卷
期数:
2018年第2期
页码:
224-227
栏目:
生物材料与力学
出版日期:
2018-02-08

文章信息/Info

Title:
 Magnetic properties of arsenic trioxide magnetic microparticles
文章编号:
1005-202X（2018）02-0224-04
作者:
 汪峰
 广州医科大学生物医学工程系， 广东 广州 510182
Author(s):
 WANG Feng
 Department of Biomedical Engineering, Guangzhou Medical University, Guangzhou 510182, China
关键词:
 ; 三氧化二砷; 磁性微球; 磁滞回线; PLGA
Keywords:
 ; As2O3;  magnetic microparticles;  magnetic hysteresis loop;  PLGA
分类号:
O645.162
DOI:
DOI:10.3969/j.issn.1005-202X.2018.02.021
文献标志码:
A
摘要:
 目的：制备包裹三氧化二砷的磁性微球，分别测量磁性微球中三氧化二砷和四氧化三铁的含量，并分析其磁性能。讨论包裹三氧化二砷的磁性微球的磁靶向性效果和临床应用的可能性。 方法：采用化学共沉淀法制备四氧化三铁纳米铁磁粒子，采用w/o/w复乳法将纳米铁磁粒子和三氧化二砷包裹于聚D，L乳酸-羟基乙酸共聚物（PLGA）高分子材料中制备成磁性微球，利用全谱直读等离子体原子发射光谱仪测量磁性微球的载药量，分别测量纳米铁磁粒子和磁性微球的磁滞回线，并检验磁性微球的磁分离效果。 结果：纳米铁磁粒子和磁性微球的矫顽力和剩余磁化强度均接近零，但磁性微球的饱和磁化强度大大低于纳米铁磁粒子的饱和磁化强度。磁性微球的磁分离效果明显。 结论：合成的磁性微球外壳由PLGA高分子材料组成，纳米级四氧化三铁分散于PLGA中，壳内是三氧化二砷水溶液。磁性微球具有超顺磁性和磁靶向性。
Abstract:
 Objective To prepare As2O3 magnetic microparticles and independently determine the drug loading and analyze the magnetic properties of As2O3 and Fe3O4 in magnetic microparticles, furthermore, discuss the magnetic targeting and the possible clinical application of As2O3 magnetic microparticles. Methods Fe3O4 nanoparticles were synthesized by chemical precipitation, and PLGA microparticles enwrapping As2O3 and Fe3O4 nanoparticles were synthesized with w/o/w double emulsion method. The drug loading capacity of the magnetic microparticle was measured by spectrum direct reading plasma atomic emission spectrometer. Magnetic hysteresis loops of Fe3O4 nanoparticles and magnetic microparticles were also measured, and the magnetic separation performance of magnetic microparticles was verified. Results The coercivity and remanent magnetization of Fe3O4 nanoparticles and magnetic microparticles were near to zero, but the saturation magnetization of Fe3O4 nanoparticles was consumedly higher than that of magnetic microparticles. The magnetic separation performance of magnetic microparticles was obvious. Conclusion The crust of the synthesized magnetic microparticle was made up of PLGA, with Fe3O4 nanoparticles scattering in PLGA, and the core was made up of As2O3 solution. The prepared magnetic microparticles had superparamagnetism and magnetic targeting.

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备注/Memo

备注/Memo:
 【收稿日期】2017-07-21
【基金项目】广州市教育局课题（B17004001）
【作者简介】汪峰，副教授，主要研究方向：纳米技术在医学中的应用，E-mail: wangfengxiaoqi@sina.com
更新日期/Last Update: 2018-01-29