Magnetic resonance imaging characteristics of resting-state brain function in children with nonsyndromic cleft lip and palate after surgical repair and speech rehabilitation(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2022年第2期
- Page:
- 177-181
- Research Field:
- 医学影像物理
- Publishing date:
Info
- Title:
- Magnetic resonance imaging characteristics of resting-state brain function in children with nonsyndromic cleft lip and palate after surgical repair and speech rehabilitation
- Author(s):
- CHENG Hua1; RAO Bo2; ZHANG Wenjing3; CHEN Renji3; PENG Yun1
- 1. Radiology Center, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing 100045, China 2. Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China 3. Department of Oral and Maxillofacial Plastic and Trauma Surgery, Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, China
- Keywords:
- Keywords: children nonsyndromic cleft lip and palate resting-state brain function magnetic resonance imaging
- PACS:
- R318
- DOI:
- DOI:10.3969/j.issn.1005-202X.2022.02.008
- Abstract:
- Abstract: Objective To explore the resting-state brain functional patterns in pediatric patients with nonsyndromic cleft lip and palate (NSCLP) after surgical repair and speech rehabilitation. Methods A total of 28 pediatric patients with NSCLP treated in Beijing Childrens Hospital and Beijing Stomatological Hospital and 28 gender- and age-matched healthy controls were enrolled and examined by 3DT1 and resting-state functional MRI. DPARSFA software was used for preprocessing and calculating the amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo). Two-sample t-test (TFCE correction, P<0.05) was used for evaluating inter-group differences. In addition, a correlation analysis between the Chinese language clear degree scale (CLCDS) scores and the resting-state properties of brain regions with significant differences in NSCLP children after rehabilitation was carried out. Results For the pediatric patients with NSCLP, decreased ALFF values were detected in the left middle temporal gyrus, left middle occipital gyrus, right cuneus, right precuneus, left postcentral gyrus, left superior parietal lobule, and decreased ReHo values were found in the left postcentral gyrus, left precentral gyrus, left superior parietal lobule, left supramarginal gyrus and left paracentral lobule. There was no significant correlation between the resting-state properties (ALFF value and ReHo value) of brain regions with significant differences and CLCDS scores. Conclusion The spontaneous neuron activities and their coordination of NSCLP children after surgical repair and speech rehabilitation have not yet fully restored to the normal level, and the involved brain regions are mainly related to language in the dominant cerebral hemisphere.
Last Update: 2022-03-07