Abstract

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Title:: Correlation between contrast-enhanced SWI sequence and detection of brain metastases from lung cancer

Author(s):: LI Jiamin1; 2; OU Jiehao2; LI Xiaodan2; KANG Zhuang3; ZHOU Meijuan1; 1. Department of Radiation Medicine, School of Public Health, Southern Medical University, Guangzhou 510515, China 2. Department of Radiology, Guangdong Provincial Peoples Hospital (Guangdong Academy of Medical Sciences), Guangzhou 510080, China 3. Department of Radiology, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China

Keywords:: factors of microbleeds; but the incidence of microbleeds caused by lung cancer brain metastasis is significantly higher. Keywords: lung cancer brain metastases susceptibility-weighted imaging contrast-enhanced microbleed

Abstract:: Objective To study the correlation of contrast-enhanced susceptibility-weighted imaging (CE-SWI) to the detection of brain metastases from lung cancer. Methods Fifty cases of brain metastases from lung cancer were enrolled as case group, and 50 cases of hypertension as control group. The microbleeds, number of lesions and maximum diameter of lesions in patients were detected by SWI and CE-SWI, separately. Chi square test was used to analyze the difference in detection results between two groups and Logistic regression was used to analyze the correlations between CE-SWI and brain metastasis from lung cancer or hypertensive microbleeds. Results The CE-SWI findings showed that there were 45 patients with 127 lesions in case group, with the maximum lesion diameter of 5.428 (3.663, 11.405) mm, and that there were 28 patients with 121 lesions in control group, with the maximum lesion diameter of 3.259 (2.206, 4.325) mm. Chi square test showed that the detection results were statistically different in two groups (P<0.05). In the correlation test, the odds ratio of microbleeds in case group was higher than that in control group, with significant differences (P<0.05). Conclusion CE-SWI is sensitive to the detections of microbleeds and brain metastases. Both lung cancer brain metastasis and hypertension are risk factors of microbleeds, but the incidence of microbleeds caused by lung cancer brain metastasis is significantly higher.