Abstract

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Title:: A simulation analysis on the unsteady flow field at outlet of intra-aortic percutaneous left ventricular assist pump and its influence

Author(s):: WANG Fei1; CHENG Yunzhang1; ZHENG Qiwen2; ZHANG Jinli1; TANG Jie1; 1. School of Medical instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China 2.ForQaly Medical(Shanghai) Company Limited, Shanghai 201138, China

Keywords:: Keywords: Percutaneous left ventricular assist pump numerical simulation shear stress pressure aorta

Abstract:: Abstract: Objective To analyze the radial flow at the outlet of intra-aorta percutaneous left ventricular assist pump and itspossibility of damage to aortic endothelial cells. Methods Based on computational fluid dynamics (CFD), the numerical imitation of unsteady flow was carried in a percutaneous left ventricular assist pump with different aortic diameters of 20, 30 mm, and 40 mm, and the flow field distribution at the outlet of the pump was analyzed. The effects of radial blood flow on aortic vascular endothelial cells were analyzed by studying the distribution of velocity, pressure and shear stress. Results The results showed that the radial blood flow at the outlet of the pump increased the normal stresses of the three models by respectively 24, 17 mmHg, and 8 mmHg, and the proportions of near-wall shear stress greater than 25 Pa are 19.3%, 13.6%, and 3%, respectively. Conclusions Experiments showed that the percutaneous left ventricular assist pump can increase the aortic pressure and near-wall shear stress, and the smaller the aortic diameter, the more obvious the effect.Therefore, patients with small diameter of aorta, hypertension or arterial lesions should be cautious to use.