Abstract

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Author(s):: WANG Feng; Department of Biomedical Engineering, Guangzhou Medical University, Guangzhou 510182, China

Abstract:: Objective To prepare As2O3 magnetic microparticles and independently determine the drug loading and analyze the magnetic properties of As2O3 and Fe3O4 in magnetic microparticles, furthermore, discuss the magnetic targeting and the possible clinical application of As2O3 magnetic microparticles. Methods Fe3O4 nanoparticles were synthesized by chemical precipitation, and PLGA microparticles enwrapping As2O3 and Fe3O4 nanoparticles were synthesized with w/o/w double emulsion method. The drug loading capacity of the magnetic microparticle was measured by spectrum direct reading plasma atomic emission spectrometer. Magnetic hysteresis loops of Fe3O4 nanoparticles and magnetic microparticles were also measured, and the magnetic separation performance of magnetic microparticles was verified. Results The coercivity and remanent magnetization of Fe3O4 nanoparticles and magnetic microparticles were near to zero, but the saturation magnetization of Fe3O4 nanoparticles was consumedly higher than that of magnetic microparticles. The magnetic separation performance of magnetic microparticles was obvious. Conclusion The crust of the synthesized magnetic microparticle was made up of PLGA, with Fe3O4 nanoparticles scattering in PLGA, and the core was made up of As2O3 solution. The prepared magnetic microparticles had superparamagnetism and magnetic targeting.