Abstract

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Title:: Therapeutic efficacy and safety of photodynamic therapy combined with holmium laser in condyloma acuminatum

Author(s):: WANG Jingwen; WANG Jing; WANG Na; LI Qing; ZHANG Tingfang; YANG Chunjun; Department of Dermatology, the Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China

Keywords:: Keywords: photodynamic therapy holmium laser condyloma acuminatum

Abstract:: Abstract: Objective To study the therapeutic efficacy and safety of the treatment combining photodynamic therapy with holmium laser in condyloma acuminatum. Methods According to the treatment schemes, 120 cases of condyloma acuminatum were divided into 3 groups for holmium laser treatment, photodynamic therapy and the combined treatment, with 40 in each group. The treatment outcome, adverse reactions and recurrence rate were statistically analyzed to explore the therapeutic value of the 3 treatment schemes for condyloma acuminatum. Results The combined treatment was superior to holmium laser treatment and photodynamic therapy in therapeutic efficacy, and the latter two had similar therapeutic efficacy. During treatment and follow-up, none of the patients had obvious adverse reactions. After 6 months of follow-up, the recurrence rates differed significantly in the combined treatment group, photodynamic therapy group and hoimium laser treatment group which were 10.0%, 17.5%, and 30.0%, respectively (P=0.001). Conclusion Photodynamic therapy combined with holmium laser can serve as a safe, effective and rapid method for the treatment of condyloma acuminatum.