Abstract

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Title:: Research progress of bone marrow mesenchymal stem cells combined with 3D bioprinting technology in the treatment of bone defects

Author(s):: YUAN Yu; XU Lin; Yantai Affiliated Hospital of Binzhou Medical University, Yantai 264010, China

Keywords:: Keywords: bone marrow mesenchymal stem cells bone tissue engineering osteogenic differentiation 3D printing review

Abstract:: Abstract: Bone defect has always been a difficult problem in clinical treatment, and autogenous bone or artificial bone transplantation is the main treatment at present. However, due to the damage caused by autologous bone graft and the limited and expensive resources of artificial bone, bone transplantation cannot be widely applied in clinical practice. In recent years, the scholars at home and abroad have paid more and more attention to the study of bone marrow mesenchymal stem cells (BMSCs) for they can induce osteogenic differentiation, and have made great progress in their isolation, extraction and directional differentiation. BMSCs can differentiate into osteoblasts, chondrocytes, etc., without rejection reaction and ethical problems. When combined with 3D bioprinting technology, it has advantages of precision and controllability in repairing bone defects and is a new bone defect repair technology with great potential and prospects. In this paper, the studies of the biological characteristics and osteogenic induction of BMSCs as well as its treatment of bone defects combined with carrier scaffolds were reviewed to provide a theoretical basis for the clinical treatment of bone defects in the future.