Objective To investigate the value of three-dimensional power Doppler ultrasound for the prediction of fetal growth restriction (FGR). Methods A total of 231 pregnant women with normal singleton pregnancy who underwent NT examination of prenatal early pregnancy in Nanfang Hospital of Southern Medical University from December 2016 to December 2017 were prospectively selected as subjects. The volume data obtained by three-dimensional power Doppler of placenta in early pregnancy were saved to the hard disk, and all pregnant women were followed up until their babies were born. According to the follow-up results, they were divided into FGR group (n=11) and normal group (n=220). GE 4DView software was used for the off-line measurement of placenta volumes and placental vascular indexes, including placental vascularization index, blood flow index and vascularization-blood flow index. Results The placental vascularization index, vascularization-blood flow index in FGR group were significantly lower than those in normal group, with statistical differences (P<0.05). Conclusion Three-dimensional power Doppler ultrasound of placenta in early pregnancy, which provides a quantitative index for the early prediction of FGR, is of great significance and is worthy of popularization and application.