[1]李仁年,李志雄,韩伟,等.主动脉出口血压对左心室血流特性的影响[J].中国医学物理学杂志,2022,39(12):1550-1557.[doi:DOI:10.3969/j.issn.1005-202X.2022.12.015]
　LI Rennian,LI Zhixiong,HAN Wei,et al.Effects of aortic outlet blood pressure on left ventricular blood flow characteristics[J].Chinese Journal of Medical Physics,2022,39(12):1550-1557.[doi:DOI:10.3969/j.issn.1005-202X.2022.12.015]
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主动脉出口血压对左心室血流特性的影响()
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《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

卷:
39卷
期数:
2022年第12期
页码:
1550-1557
栏目:
生物材料与力学
出版日期:
2022-12-25

文章信息/Info

Title:
Effects of aortic outlet blood pressure on left ventricular blood flow characteristics
文章编号:
1005-202X（2022）12-1550-08
作者:
李仁年1; 李志雄1; 韩伟1; 冯慧敏1; 郝英剑1; 任嘉乐1; 强彦1; 2
1.兰州理工大学能源与动力工程学院， 甘肃 兰州 730050； 2.东南大学能源与环境学院， 江苏 南京 210096
Author(s):
LI Rennian1;  LI Zhixiong1;  HAN Wei1;  FENG Huimin1;  HAO Yingjian1;  REN Jiale1;  QIANG Yan1; 2
1. School of Energy and Power Engineering, Lanzhou University of Technology, Lanzhou 730050, China 2. School of Energy and Environment, Southeast University, Nanjing 210096, China
关键词:
心脏; 左心室; 血压; 动网格; 血流特性
Keywords:
Keywords: heart left ventricle blood pressure dynamic grid blood flow characteristic
分类号:
R318；Q811.6
DOI:
DOI:10.3969/j.issn.1005-202X.2022.12.015
文献标志码:
A
摘要:
采用Mimics对心脏进行三维重构，用3-matic进行模型优化以及模型误差分析，对左心室室壁运动做速度分布假设，基于UDF宏文件对左心室室壁运动编写程序，将血液视为非牛顿流体，采用动网格技术研究不同血压对左心室血液流动的影响。模拟发现当左心室收缩时，压力梯度明显，内部压力减小。当左心室舒张时，内部压力逐渐增高。二尖瓣口处的速率先增大后减小。血压升高，左心室内剪切应力持续增大，极易破坏红细胞结构，产生溶血现象，导致心脏功能紊乱。
Abstract:
Abstract: Mimics is used for the 3D reconstruction of the heart, and 3-matic for model optimization and model error analysis. A velocity distribution assumption is made for the left ventricular wall motion, and the left ventricular wall motion is programmed based on the UDF macro file. The blood is regarded as a non-Newtonian fluid, and the effects of different blood pressures on left ventricular blood flow characteristics are analyzed with dynamic grid technique. The simulation results show that when the left ventricle contracts, there are obvious pressure gradient and decreasing internal pressure and that when the left ventricle relaxes, the internal pressure gradually increases. The velocity at the mitral valve orifice increases first and then decreases. With the elevation of blood pressure, the shear stress in the left ventricle continues to increase, which can easily destroy the structure of red blood cells, causing hemolysis and leading to cardiac dysfunctions.

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备注/Memo

备注/Memo:
【收稿日期】2022-07-06 【基金项目】国家自然科学基金（51966010） 【作者简介】李仁年，博士，教授，研究方向：流体机械及工程，E-mail: lirn@lut.edu.cn 【通信作者】强彦，博士，副教授，研究方向：流体测量与控制，E-mail: qiangyan0206@163.com
更新日期/Last Update: 2022-12-23